RESUMO
Extravasation injuries are common in patients receiving multiple intravenous infusions. Although such injuries are closely associated with the infusion of cytotoxic chemotherapy, they have also been been associated with extravasation of noncytotoxic drugs. Extravasation injuries can lead to skin ulceration and nerve and tendon damage, and therefore to permanent disability. We report three cases of phosphate solution extravasation leading to unusual cutaneous manifestations.
Assuntos
Extravasamento de Materiais Terapêuticos e Diagnósticos/complicações , Fosfatos/efeitos adversos , Úlcera Cutânea/etiologia , Pele/patologia , Adulto , Idoso , Cateterismo Periférico/efeitos adversos , Feminino , Humanos , Infusões Intravenosas/efeitos adversos , Linfócitos , Masculino , Pessoa de Meia-Idade , Fosfatos/administração & dosagem , Úlcera Cutânea/patologiaRESUMO
We report simulation of EPR spectra directly and entirely from trajectories generated from molecular dynamics simulations. Results are reported for a model 3beta-DOXYL-5alpha-cholestane spin probe in a coarse-grained solvent representing a 5CB nematic host. The results are in excellent agreement with the experimental spectra. The calculated order parameters associated with the paramagnetic probe show strong correlation with the order parameter of 5CB mesogens and are in agreement with those reported in the literature. Simulation of EPR spectra entirely from molecular dynamics of real structures provides direct correlation between molecular motions and the features observed in the spectra, allowing unambiguous interpretation of the spectra. This method opens the possibility for "computer engineering" of spin-labeled materials with the desired properties, such as spin-labeled proteins, prior to experiment.