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1.
Arthrosc Tech ; 7(7): e739-e745, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30094145

RESUMO

Posterior shoulder instability is an uncommon and challenging cause of shoulder pain and dysfunction. Surgical management has less reliable results and higher failure rates compared with techniques for anterior shoulder instability. The presence of generalized ligamentous laxity further complicates options for surgical management. If primary capsulolabral repair fails, controversy exists as to the optimal revision procedure. This technical description and video present an arthroscopic technique for reconstruction of the posterior glenohumeral capsule with an acellular dermal allograft to treat posterior instability in a patient with Ehlers-Danlos syndrome and a previously failed posterior capsular plication.

2.
Arthroscopy ; 34(8): 2294-2297, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-30077255

RESUMO

The debate between arthroscopic Bankart repair versus the Latarjet technique for patients with anterior shoulder instability largely hinges on the argument between redislocation rate versus complication rate. This difference becomes more apparent when considering patients with bone loss. We believe that Bankart "plus" techniques, including arthroscopic anatomic bone grafting, create a stable shoulder with a low instability recurrence rate, while maintaining a complication rate comparable to the Bankart repair.


Assuntos
Articulação do Ombro , Artroscopia , Humanos , Recidiva , Estudos Retrospectivos , Ombro , Resultado do Tratamento
3.
Bioorg Med Chem Lett ; 21(15): 4512-5, 2011 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-21723121

RESUMO

The synthesis (Pd-mediated coupling strategy) and characterization (NMR, IR, elemental analysis, etc.) of a short series of quinoline-oxazole hybrid compounds has been carried out. These materials are found to be moderately active against Plasmodium falciparum in vitro, with activities in the sub-micromolar range, and to display acceptable cytotoxicity to mononuclear leukocytes. Chemical modification strategies, with the intention to increase the biological potency of this new class of anti-malarial agents, are discussed.


Assuntos
Antimaláricos/síntese química , Cloroquina/química , Plasmodium falciparum/efeitos dos fármacos , Antimaláricos/química , Antimaláricos/farmacologia , Cloroquina/síntese química , Cloroquina/farmacologia , Modelos Biológicos , Oxazóis/química , Quinolinas/química
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