Pair Creation with Strong Laser Fields, Compton Scale X Rays, and Heavy Nuclei.

Electron-positron pair creation is considered when intense laser pulses collide head-on with <1 MeV x-ray photons in the presence of stationary Coulomb charges Z(-e). The analysis employs Coulomb-corrected Volkov states and is not limited to Born's approximation in Z. The cross section and the yield increase dramatically with increasing Z, potentially enabling (i) measurable yields with petawatt lasers and (ii) sensitive tests of strong-field QED.

Lensing properties of rotational gas flow: erratum.

This erratum includes additional references relevant to rotational gas flow negative lenses that were omitted in Appl. Opt.57, 9392 (2018)APOPAI0003-693510.1364/AO.57.009392.

Lensing properties of rotational gas flow.

A negative lens comprising a gas in steady axisymmetric flow is demonstrated experimentally and analyzed. The lens has potential applications in high-intensity laser optics and presents the possibility of adjusting the focusing properties on a submillisecond time scale. It can be operated in environments where conventional optical elements are vulnerable.

First Benchmark of Relativistic Photoionization Theories against 3D ab initio Simulation.

Photoelectron spectra and ionization rates encompassing relativistic intensities and hydrogenlike ions with relativistic binding energies are obtained using a quasiclassical S-matrix approach. These results, along with those based on the imaginary time method, are compared with three-dimensional, ½-period ab initio simulations for a wide range of ionization potentials and electric field amplitudes. Significant differences between the three results are demonstrated. Time-dependent simulations indicate that the peak ionization current can occur before the peak of the electric field.

Laser-Accelerated Ions from a Shock-Compressed Gas Foil.

We present results of energetic laser-ion acceleration from a tailored, near solid density gas target. Colliding hydrodynamic shocks compress a pure hydrogen gas jet into a 70 µm thick target prior to the arrival of the ultraintense laser pulse. A density scan reveals the transition from a regime characterized by a wide angle, low-energy beam (target normal sheath acceleration) to one of a more focused beam with a high-energy halo (magnetic vortex acceleration). In the latter case, three-dimensional simulations show the formation of a Z pinch driven by the axial current resulting from laser wakefield accelerated electrons. Ions at the rear of the target are then accelerated by a combination of space charge fields from accelerated electrons and Coulombic repulsion as the pinch dissipates.

Simulation of free-space optical guiding structure based on colliding gas flows: erratum.

A typographical error in Kaganovich et al. [Appl. Opt.54, F144 (2015)10.1364/AO.54.00F144APOPAI0003-6935] is corrected here.

Simulation of free-space optical guiding structure based on colliding gas flows.

Preformed plasma channels with parabolic radial density profiles enable the extended and stable optical guiding of high-intensity laser pulses. High-voltage discharge capillaries, commonly used for channel formation, have limited guiding length and opaque walls, complicating the diagnosis of the plasma within. This paper proposes a free-space gas channel produced by the collision of several gas flows. The collision of the gas flows forms an on-axis density depression surrounded by higher density walls. By offsetting the flows, we demonstrated the creation of what we believe is a novel vortex structure that exhibits a long-lived parabolic density profile. Once ionized, the resulting plasma density profile has a near-parabolic dependence appropriate for guiding. We then performed detailed two-dimensional (2D) fluid dynamics simulations to examine the properties and stability of the guiding structure.

Stimulated Raman scattering and nonlinear focusing of high-power laser beams propagating in water.

The physical processes associated with propagation of a high-power (power > critical power for self-focusing) laser beam in water include nonlinear focusing, stimulated Raman scattering (SRS), optical breakdown, and plasma formation. The interplay between nonlinear focusing and SRS is analyzed for cases where a significant portion of the pump power is channeled into the Stokes wave. Propagation simulations and an analytical model demonstrate that the Stokes wave can re-focus the pump wave after the power in the latter falls below the critical power. It is shown that this novel focusing mechanism is distinct from cross-phase focusing. The phenomenon of gain-focusing discussed here for propagation in water is expected to be of general occurrence applicable to any medium supporting nonlinear focusing and stimulated Raman scattering.

Origin and control of the subpicosecond pedestal in femtosecond laser systems.

The picosecond time scale pedestal of a multiterawatt femtosecond laser pulse is investigated experimentally and analytically. The origin of the pedestal is related to the finite bandwidth of the laser system. By deliberately introducing a modulated spectrum with minima that match this limited bandwidth, the pedestal can be reduced, with no deleterious effect on the main pulse. Using this technique, we experimentally demonstrate a subpicosecond scale order of magnitude enhancement of contrast ratio while preserving the energy in the main pulse.

Laser heating of uncoated optics in a convective medium.

Powerful, long-pulse lasers have a variety of applications. In many applications, optical elements are employed to direct, focus, or collimate the beam. Typically the optic is suspended in a gaseous environment (e.g., air) and can cool by convection. The variation of the optic temperature with time is obtained by combining the effects of laser heating, thermal conduction, and convective loss. Characteristics of the solutions in terms of the properties of the optic material, laser beam parameters, and the environment are discussed and compared with measurements at the Naval Research Laboratory, employing kW-class, 1 µm wavelength, continuous wave lasers and optical elements made of fused silica or BK7 glass. The calculated results are in good agreement with the measurements, given the approximations in the analysis and the expected variation in the absorption coefficients of the glasses used in the experiments.

PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism.

Pitx2 is a homeodomain transcription factor required in a dose-dependent manner for the development of multiple organs. Pitx2-null homozygotes (Pitx2(-/-)) have severe pituitary hypoplasia, whereas mice with reduced-function alleles (Pitx2(neo/neo)) exhibit modest hypoplasia and reduction in the developing gonadotroph and Pou1f1 lineages. PITX2 is expressed broadly in Rathke's pouch and the fetal pituitary gland. It predominates in adult thyrotrophs and gonadotrophs, although it is not necessary for gonadotroph function. To test the role of PITX2 in thyrotroph function, we developed thyrotroph-specific cre transgenic mice, Tg(Tshb-cre) with a recombineered Tshb bacterial artificial chromosome that ablates floxed genes in differentiated pituitary thyrotrophs. We used the best Tg(Tshb-Cre) strain to generate thyrotroph-specific Pitx2-deficient offspring, Pitx2(flox/-;)Tg(Tshb-cre). Double immunohistochemistry confirmed Pitx2 deletion. Pitx2(flox/-);Tg(Tshb-cre) mice have a modest weight decrease. The thyroid glands are smaller, although circulating T(4) and TSH levels are in the normal range. The pituitary levels of Pitx1 transcripts are significantly increased, suggesting a compensatory mechanism. Hypothyroidism induced by low-iodine diet and oral propylthiouracil revealed a blunted TSH response in Pitx2(flox/-);Tg(Tshb-cre) mice. Pitx1 transcripts increased significantly in control mice with induced hypothyroidism, but they remained unchanged in Pitx2(flox/-);Tg(Tshb-cre) mice, possibly because Pitx1 levels were already maximally elevated in untreated mutants. These results suggest that PITX2 and PITX1 have overlapping roles in thyrotroph function and response to hypothyroidism. The novel cre transgene that we report will be useful for studying the function of other genes in thyrotrophs.

Measurement of electro-optic shock and electron acceleration in a strongly cavitated laser wakefield accelerator.

Conically emitted second harmonic radiation was observed when a relativistically intense, ultrashort laser pulse was focused into a jet of gas. This second harmonic electro-optic shock is the result of frequency mixing within the sheath of electrons surrounding a highly cavitated plasma region created by the ponderomotive force of the laser. Strong correlation between the second harmonic characteristics and electron acceleration has been observed.

Nonlinear conversion of photon spin to photon orbital angular momentum.

A relativistically intense, ultrashort laser pulse with purely spin angular momentum produces second-harmonic radiation with equal parts of both spin and orbital angular momentum when focused into a plasma. The orbital contribution is due to an azimuthal phase variation that arises in the nonlinear current density. This phase variation is associated with the radial nonuniformity driven by ponderomotive blowout.

Electro-optic shocks from ultraintense laser-plasma interactions.

Second harmonic radiation in the form of an electro-optic shock is produced in the blowout regime of a laser wakefield in a plasma. The shock is produced by the interaction between the laser field and the electron sheath surrounding the electron cavitation region. Because the sheath is thin, phase matching is unimportant, and the radiated energy grows secularly with the interaction length. The angle of emission is given by the Cherenkov angle associated with the ratio of the second harmonic phase velocity to the fundamental phase velocity. The shock formation is investigated in three dimensions via analysis and particle-in-cell simulations.

Observation of large-angle quasimonoenergetic electrons from a laser wakefield.

A relativistically intense laser pulse is focused into a helium jet and quasimonoenergetic electrons emitted at a 40 degrees angle with respect to the laser axis are observed. The average electron energy is between 1 and 2 MeV and the total accelerated charge is about 1 nC emitted in a 10 degrees cone angle. Three dimensional particle-in-cell simulations reproduce key features of the experimental results and show that the interaction between ionization heating and nonlinear cavitation wakefields is responsible for the acceleration.

Characterization of the third-harmonic radiation generated by intense laser self-formed filaments propagating in air.

We perform laboratory experiments to study ultraviolet radiation generated by intense self-formed laser filaments produced by propagating high-power femtosecond laser pulses in air. The laser used in the experiment is a 0.5 TW Ti:sapphire system with the center wavelength at 800 nm. The observed ultraviolet emission occurs in the form of the third harmonic and frequency-upshifted radiation from the fundamental. We present direct characterization of the generated harmonic and frequency-upshifted radiation, including transverse imaging and spatially resolved spectral measurements.

Quasimonoenergetic electrons from unphased injection into channel guided laser wakefield accelerators.

A high-quality electron beam can be extracted from a channel guided laser wakefield accelerator without confining the injected particles to a small region of phase. By careful choice of the injection energy, a regime can be found where uniformly phased particles are quickly bunched by the accelerator itself and subsequently accelerated to high energy. The process is particularly effective in a plasma channel because of a favorable phase shift that occurs in the focusing fields. Furthermore, particle-in-cell simulations show that the self-fields of the injected bunches actually tend to reduce the energy spread on the final beam. The final beam characteristics can be calculated using a computationally inexpensive Hamiltonian formulation when beam-loading effects are minimal.

Electron distribution function in short-pulse photoionization.

Two well-known limiting regimes of photoionization, when a laser beam interacts with a gas, correspond to the tunneling and the multiphoton processes. The latter dominates in the low-intensity regime, while the former is appropriate at higher intensities. Electrons are born with negligible velocity in tunneling ionization, while in l-photon ionization they are born with a fixed energy determined by l, the photon energy and the ionization potential of the molecule. The transport equation for the distribution function of electrons can be integrated along the characteristics defined by the classical equations of motion in the laser field. Expressions for the distribution function have been obtained in the two regimes using the appropriate analytical form for the ionization rate. Results from two-dimensional particle-in-cell simulations and illustrative plots of the distribution function are presented and discussed.

Asymmetric self-phase modulation and compression of short laser pulses in plasma channels.

A relativistically intense femtosecond laser pulse propagating in a plasma channel undergoes dramatic photon deceleration while propagating a distance on the order of a dephasing length. The deceleration of photons is localized to the back of the pulse and is accompanied by compression and explosive growth of the ponderomotive potential. Fully explicit particle-in-cell simulations are applied to the problem and are compared with ponderomotive guiding center simulations. A numerical Wigner transform is used to examine local frequency shifts within the pulse and to suggest an experimental diagnostic of plasma waves inside a capillary.

Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2.

Mice homozygous for the targeted disruption of the glycoprotein hormone alpha-subunit (alphaGsu) display hypertrophy and hyperplasia of the anterior pituitary thyrotropes. Thyrotrope hyperplasia results in tumors in aged alphaGsu(-/-) mice. These adenomatous pituitaries can grow independently as intrascapular transplants in hypothyroid mice, suggesting that they have progressed beyond simple hyperplasia. We used magnetic resonance imaging to follow the growth and regression of thyrotrope adenomatous hyperplasia in response to thyroid hormone treatment and discovered that the tumors retain thyroid hormone responsiveness. Somatostatin (SMST) and its diverse receptors have been implicated in cell proliferation and tumorigenesis. To test the involvement of SMST receptor 2 (SMSTR2) in pituitary tumor progression and thyroid hormone responsiveness in alphaGsu(-/-) mutants, we generated Smstr2(-/-), alphaGsu(-/-) mice. Smstr2(-/-), alphaGsu(-/-) mice develop hyperplasia of thyrotropes, similar to alphaGsu(-/-) mutants, demonstrating that SMSTR2 is dispensable for the development of pituitary adenomatous hyperplasia. Thyrotrope hyperplasia in Smstr2(-/-), alphaGsu(-/-) mice regresses in response to T4 treatment, suggesting that SMSTR2 is not required in the T4 feedback loop regulating TSH secretion.