RESUMO
A study was made of some embryological, hematological, cytogenetic and biochemical characteristics in Wistar rats exposed within the Chernobyl NPP zone over a period of 30 days (the average radiation background level, 75, and at the soil surface, 115 mR/h; a cumulative dose, 57 rad/30 days, and for pregnant rats, 36 rad/20 days). The quantity of chromosome aberrations in bone marrow metaphases and the embryonal death rate were invariable; some cases of teratogenesis were, however, observed. The total number of karyocytes in the brain and the leukocyte content in the peripheral blood sometimes decreased. The changes in certain characteristics (such as the content of endogenous amines and thiols in the liver and spleen) of the endogenous radioresistance background (ERB) and the normalization of the ERB by the radioprotective agent MIGI-K were found.
Assuntos
Acidentes , Poluentes Radioativos do Ar/efeitos adversos , Reatores Nucleares , Centrais Elétricas , Lesões Experimentais por Radiação/tratamento farmacológico , Protetores contra Radiação/uso terapêutico , Animais , Relação Dose-Resposta à Radiação , Avaliação Pré-Clínica de Medicamentos , Feminino , Masculino , Lesões Experimentais por Radiação/metabolismo , Lesões Experimentais por Radiação/patologia , Ratos , Ratos Wistar , UcrâniaRESUMO
It has been shown that the process of amines new formation in mast cells after the treatment with radioprotectors is less intensive than in other tissues able to synthesize amines. It is proposed that the effect of the mast cells in organism's formation of higher radioresistance is brought to mobilization of the accumulated biogenic amines with their further redistribution in other organs and tissues including radiosensitive ones.