[Clinical-chemical studies in schizophrenic out-patients under neuroleptic long-term treatment with particular consideration of the hepatic metabolism (author's transl)]. / Laborklinische Untersuchungen unter besonderer Berücksichtigung des Leberstoffwechsels bei Schizophrenen unter ambulanter neuroleptischer Langzeitmedikation.

A series of clinical-chemical tests was conducted in 68 schizophrenic out-patients under long-term neuroleptic medication, with particular consideration of the hepatic metabolism, i.e.: Erythrocyte sedimentation rate, alpha 1-glycoprotein, ceruloplasmin, fibrinogen, GPT, GOT, gamma-GT, total protein and serum-protein-electrophoresis. Furthermore, the glucose tolerance tests was carried out. In 44% of the patients an increased erythrocyte sedimentation rate and positive correlations with increased fibrinogen values were found. Increased gamma-GT-values were proven in 33% of the patients; they correlated positively with the increased GPT-and/or GOT-values as well as with pathological glucose tolerance values. Overweight of more than 10 kilos was found in 46% of the patients. A significant correlation between overweight and pathological glucose tolerance values existed. The results were interpreted as consequence of a light fatty liver.

[Oral glucose tolerance test in schizophrenics under long-term neuroleptic treatment (author's transl)]. / Einzeitige orale Glukosebelastung bei langfristig neuroleptisch behandelten Schizophrenen

The oral glucose tolerance test was carried out in 58 schizophrenics under long-term treatment with different neuroleptic drugs. 74% of the patients showed hyperglycemic reactions. The results did not show any correlation to the age of the patients. The oral glucose tolerance test using 100 g of glucose is recommended as routine procedure instead of the unreliable results of the fasting blood sugar determination. Several hypotheses related to the action of neuroleptics on glucose metabolism are discussed. The authors suggest that glucose tolerance tests and body weight controls should be carried out regularly under long-term neuroleptic treatment.