¿Dios mío, por qué me has abandonado? Estrés, ansiedad, depresión y afrontamiento religioso en los estudiantes de Medicina / God, why have you forsaken me? Stress, anxiety, depression and religious-coping in medical students

Antecedentes: los estudiantes de Medicina presentan niveles elevados de estrés, ansiedad y depresión. El afrontamiento religioso es una vía para entender y enfrentarse a eventos negativos en la vida que están relacionados con lo sagrado. Existen diversos estudios de asociación entre el afrontamiento religioso y los niveles de estrés, ansiedad y depresión. El objetivo del estudio fue determinar la influencia del afrontamiento religioso sobre el estrés, ansiedad y depresión en los estudiantes de Medicina de la Universidad Andina del Cusco. Métodos: estudio transversal analítico, en 317 estudiantes de Medicina de la Universidad Andina del Cusco. Se utilizó la Escala de depresión, ansiedad y estrés (DASS-21) para medir los estados estresantes y la Escala abreviada de afrontamiento religioso (Brief RCOPE), para determinar niveles de afrontamiento religioso positivo y negativo. Para la expresión de los resultados se calcularon prevalencias y frecuencias, correlación de Spearman y chi cuadrado, valor de p y el IC al 95%. Se incluyó a todos los estudiantes de Medicina que dieron su consentimiento informado y que cursaron de manera regular el ciclo académico 2020-I. Resultados: el 51,5% fueron del sexo femenino. El promedio de edad fue de 21,31 años. El 66,2% obtuvieron puntajes de depresión-moderada, severa o extremadamente-severa, el 70,9% obtuvo puntajes de ansiedad-moderada, severa o extremadamente-severa y el 42,3% presentó estrés-moderado, severo o extremadamente-severo. El afrontamiento religioso negativo tuvo una relación positiva muy significativa con el estrés, ansiedad y depresión. Interpretación: el afrontamiento religioso negativo se asoció significativa (<0,001) y positivamente con el estrés (0,252), ansiedad (0,304) y depresión (0,357), con una potencia alta (>0,5). El estudio tiene implicaciones clínicas y de salud pública.(AU)

Background: Medical students present with elevated levels of stress, anxiety, and depression. Religious coping is an avenue for understanding and coping with negative life events that are related to the sacred. There are several studies of association between religious coping and levels of stress, anxiety and depression. The aim of the study was to determine the influence of religious coping on stress, anxiety and depression in medical students of the Universidad Andina del Cusco. Methods: Analytical cross-sectional study in 317 medical students of the Universidad Andina del Cusco. The Depression, Anxiety and Stress Scale (DASS-21) was used to measure stressful states and the Abbreviated Religious Coping Scale (Brief RCOPE) to determine levels of positive and negative religious coping. For the expression of the results, prevalence and frequencies, Spearman's correlation and chi-square, p-value and 95% CI were calculated. All medical students who gave their informed consent and who regularly attended the 2020-I academic year were included. Results: Of the participants, 51.5% were female. Mean age was 21.31 years. The 66.2% obtained scores of depression-moderate, severe or extremely-severe, 70.9% obtained scores of anxiety-moderate, severe or extremely-severe and 42.3% presented stress-moderate, severe or extremely-severe. Negative religious coping had a highly significant positive relationship with stress, anxiety and depression. Interpretation: Negative religious coping was significantly (<0.001) and positively associated with stress (0.252), anxiety (0.304) and depression (0.357), with high power (>0.5). The study has clinical and public health implications.(AU)

Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain.

Gap junctional communication is mainly mediated by connexin36 and connexin43 in neurons and astrocytes, respectively. It has been suggested that connexin36 allows electrical coupling between neurons whereas connexin43 participates in several process including release of ATP. It was recently reported that blockage of gap junctional communication mediated by connexin36 can disrupt the sleep architecture of the rat. However, there is no experimental approach about effects of sleep deprivation on connexins expression. Therefore, we examined in adult male Wistar rats whether protein levels of connexin36 and connexin43 change in pons, hypothalamus, and frontal cortex after 24 h of total sleep deprivation and 4 h of sleep recovery. Western blot revealed that total sleep deprivation significantly decreases the levels of connexin36 in the hypothalamus and this decrease maintains after sleep recovery. Meanwhile, connexin43 is not altered by total sleep deprivation but interestingly the sleep recovery period induces an increase of this connexin. These results suggest that electrical coupling between hypothalamic neurons could be altered by sleep deprivation and that sleep recovery drives changes in connexin43 expression probably as a mechanism related to ATP release and energy regulation during sleep.