18F-FDG positron emission tomography as a marker of disease activity and treatment response in ankylosing spondylitis and psoriatic arthritis.

The ability of 18F-FDG positron emission tomography (PET) to track disease activity and treatment response in patients with Ankylosing Spondylitis (AS) or Psoriatic Arthritis (PsA) remains unclear. Here, we assessed whether 18F-FDG uptake is a marker of disease activity and treatment response in AS or PsA, and explored the ability of 18F-FDG to predict treatment response. Patients with AS (n = 16) or PsA (n = 8) who were scheduled to initiate treatment with biologics were recruited. Participants underwent a clinical evaluation and an 18F-FDG scan prior to therapy initiation. Eleven participants underwent a follow-up 18F-FDG scan 3 months post-treatment. Images were quantified using a composite measure that describes the inflammatory status of the patient. Clinically involved joints/entheses had higher 18F-FDG uptake compared to unaffected areas (median difference > 0.6, p < 0.01). Among patients with AS, pre-treatment 18F-FDG uptake was strongly associated with disease activity (r = 0.65, p = 0.006). Longitudinal 18F-FDG scans demonstrated that decreases in uptake at 3 months were associated to clinical response (ßΔgSUVmax > 8.5, p < 0.001). We found no significant association between pre-treatment 18F-FDG uptake and subsequent clinical response. 18F-FDG PET shows potential as a marker of disease activity in AS and PsA, allowing for monitorization of biological treatment efficacy in these patients.

Aragonite crystallization in a sulfate-rich hypersaline wetland under dry Mediterranean climate (Laguna Honda, eastern Guadalquivir basin, S Spain).

This research investigates the influence of water composition, the presence of seasonal algal mats, detrital inputs and the activity of microorganisms on the crystallization of aragonite in the sediments deposited in the hypersaline Laguna Honda wetland (S of Spain). The high alkaline and hypersaline waters (pH > 9.2 and C.E. > 70 mS/cm) of the wetland lake are rich in SO42- (>24,000 mg/l), Cl- (>21,000 mg/l), Na+ (>11,000 mg/l) Mg2+ (>8400 mg/l) and Ca2+ (>1000 mg/l), and are supersaturated for dolomite, calcite and aragonite. Sediments have lower pH values than column waters, oscillating from 8.54 in the low Eh (up to -80.9 mV) central deep sediments and 6.33 in the shallower higher Eh (around -13.6 mV) shore sediments. Erosion of the surrounding olive groves soils produced detrital silicates rich sediments with concretions of carbonate or sulfate. Aragonite (up to 19 %) and pyrite (up to 13 %) are mainly concentrated in the organic matter rich samples from the upper part of the sediment cores, whereas gypsum is preferably concentrated in low organic matter content samples. Mineral crusts containing a MgAl silicate phase, epsomite, halite and gypsum are precipitated on the floating algal mats covering the wetland waters. Floating algal mats deposit increased the organic matter content of the upper sediments which promoted the presence of fermentative microorganisms, sulfate-reducing bacteria (SRB) and sulfur-oxidizing bacteria (SOB) communities and variations of Eh that influence the authigenesis of carbonate and S-bearing minerals. Replacement of poorly crystalline MgSi phases infilling algal cells by aragonite was favored in the organic matter rich sediments with low Eh values and important SRB communities that promoted sulfate bioreduction processes to form pyrite. Aragonite precipitation was favored by the increase of carbonate and bicarbonate concentration produced by the SRB oxidation of organic matter, the CO2 degassing by high summer temperatures and the CO2 uptake by photosynthesis of the algal mats.

Body CT examinations in oncologic patients: the impact of subspecialty radiology on radiation exposure in the clinical practice. A quality care study.

PURPOSES: The primary objective of this retrospective study was to assess whether the CT dose delivered to oncologic patients was different in a subspecialty radiology department, compared to a general radiology department. The secondary explorative objective was to assess whether the objective image quality of CT examinations was different in the two settings. MATERIALS AND METHODS: Chest and abdomen CT scans performed for oncologic indications were selected from a general radiology department and a subspecialty radiology department. By using a radiation dose management platform, we extracted and compared CT dose index (CTDIvol) and dose length product (DLP) both for each phase and for the entire CT exams. For objective image quality evaluation, we calculated the signal-to-noise ratio (SNR) and the contrast-to-noise ratio (CNR) at the level of the liver and of the aorta. A P-value < 0.05 was considered significant. RESULTS: A total of 7098 CT examinations were included. CTDIvol was evaluated in 12,804 phases; DLP in 10,713 phases and in 6714 examinations. The CTDIvol and DLP overall were significantly lower in the subspecialty radiology department compared to the general radiology department CTDI median (IQR) 5.19 (3.91-7.00) and 5.51 (4.17-7.72), DLP median and IQR of 490.0 (342.4-710.6) and 503.4 (359.9-728.8), p < 0.001 and p = 0.01, respectively. The objective image quality showed no significant difference in the general and subspecialty radiology departments, with median and IQR of 4.03 (2.82-5.51) and 3.84 (3.09-4.94) for SNRLiv (p = 0.58); 4.81 (2.70-7.62) and 4.34 (3.05-6.25) for SNRAo (p = 0.30); 0.83 (0.20-1.89) and 1.00 (0.35-1.57) for CNRLiv (p = 0.99); 2.23 (0.09-3.83) and 1.01 (0.15-2.84) for CNRAo (p = 0.24) with SNRLiv (p = 0.58), SNRAo (p = 0.30), CNRLiv (p = 0.99) and CNRAo (p = 0.24). CONCLUSION: In a subspecialty radiology department, CT protocols are optimized compared to a general radiology department leading to lower doses to oncologic patients without significant objective image quality degradation.

Effects of Chronic, Low-Dose Cannabinoids, Cannabidiol, Delta-9-Tetrahydrocannabinol and a Combination of Both, on Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease.

Background: There is an urgent need for novel therapies to treat Alzheimer's disease. Among others, the use of cannabinoids such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) has been proposed as a putative approach based on their anti-inflammatory effects. Methods: The present work was designed to explore the effects of chronic (28 days) treatment with low doses of cannabinoids: CBD (0.273 mg/kg), THC (0.205 mg/kg) or a combination of both (CBD:THC; 0.273 mg/kg:0.205 mg/kg) in the 5xFAD mouse model of AD. Results: Our data revealed that THC-treated 5xFAD mice (but not other treatment groups) exhibited anxiogenic and depressant-like behavior. A significant improvement in spatial memory was observed only in the CBD:THC-treated group. Interestingly, all cannabinoid-treated groups showed significantly increased cortical levels of the insoluble form of beta amyloid 1-42. These effects were not accompanied by changes in molecular parameters of inflammation at the mRNA or protein level. Conclusions: These data reveal differential effects of chronic, low-dose cannabinoids and point to a role of these cannabinoids in the processing of amyloid peptides in the brains of 5xFAD mice.

The clinical challenges of homologous recombination proficiency in ovarian cancer: from intrinsic resistance to new treatment opportunities.

Ovarian cancer is the most lethal gynecologic cancer. Optimal cytoreductive surgery followed by platinum-based chemotherapy with or without bevacizumab is the conventional therapeutic strategy. Since 2016, the pharmacological treatment of epithelial ovarian cancer has significantly changed following the introduction of the poly (ADP-ribose) polymerase inhibitors (PARPi). BRCA1/2 mutations and homologous recombination deficiency (HRD) have been established as predictive biomarkers of the benefit from platinum-based chemotherapy and PARPi. While in the absence of HRD (the so-called homologous recombination proficiency, HRp), patients derive minimal benefit from PARPi, the use of the antiangiogenic agent bevacizumab in first line did not result in different efficacy according to the presence of homologous recombination repair (HRR) genes mutations. No clinical trials have currently compared PARPi and bevacizumab as maintenance therapy in the HRp population. Different strategies are under investigation to overcome primary and acquired resistance to PARPi and to increase the sensitivity of HRp tumors to these agents. These tumors are characterized by frequent amplifications of Cyclin E and MYC, resulting in high replication stress. Different agents targeting DNA replication stress, such as ATR, WEE1 and CHK1 inhibitors, are currently being explored in preclinical models and clinical trials and have shown promising preliminary signs of activity. In this review, we will summarize the available evidence on the activity of PARPi in HRp tumors and the ongoing research to develop new treatment options in this hard-to-treat population.

Whole-Body Composition Features by Computed Tomography in Ovarian Cancer: Pilot Data on Survival Correlations.

BACKGROUND: The primary objective of this study was to assess the associations of computed tomography (CT)-based whole-body composition values with overall survival (OS) and progression-free survival (PFS) in epithelial ovarian cancer (EOC) patients. The secondary objective was the association of body composition with chemotherapy-related toxicity. METHODS: Thirty-four patients (median age 64.9 years; interquartile range 55.4-75.4) with EOC and thorax and abdomen CT scans were included. Clinical data recorded: age; weight; height; stage; chemotherapy-related toxicity; and date of last contact, progression and death. Automatic extraction of body composition values was performed by dedicated software. Sarcopenia was defined according to predefined cutoffs. Statistical analysis included univariate tests to investigate associations of sarcopenia and body composition with chemotoxicity. Association of body composition parameters and OS/PFS was evaluated by log-rank test and Cox proportional hazard model. Multivariate models were adjusted for FIGO stage and/or age at diagnosis. RESULTS: We found significant associations of skeletal muscle volume with OS (p = 0.04) and PFS (p = 0.04); intramuscular fat volume with PFS (p = 0.03); and visceral adipose tissue, epicardial and paracardial fat with PFS (p = 0.04, 0.01 and 0.02, respectively). We found no significant associations between body composition parameters and chemotherapy-related toxicity. CONCLUSIONS: In this exploratory study, we found significant associations of whole-body composition parameters with OS and PFS. These results open a window to the possibility to perform body composition profiling without approximate estimations.

Spiritual Experiences of Portuguese Women Who had a Water Birth.

This study aimed to understand the significance of spirituality to Portuguese women who had a water birth. In-depth interviews, using a semi-structured questionnaire, were conducted with 24 women who experienced water birth at the hospital or home. Results were analyzed from a narrative interpretation perspective. Three spirituality-related categories emerged: (1) Beliefs and connections with the body; (2) Spirituality: integration of being a woman and transformation during birth; and (3) Spirituality as wisdom, intuition, or the sixth sense. Spirituality was perceived in women's faith and beliefs in a superior being that helped them manage the unpredictability and uncontrollability of giving birth.

Preliminary Study of the Bactericide Properties of Biodegradable Polymers (PLA) with Metal Additives for 3D Printing Applications.

Plastic is a highly used material in various sectors. Due to its plentiful availability in the environment, microorganism surface contamination is a risk. The aim of this work is to achieve bactericidal capacity in plastics that reduces the microorganism's colonization risk and, consequently, reduces the chances of having an infection with E. coli and Listeria monocytogenes bacteria. Using polylactic acid (PLA) as the polymeric matrix, mixtures in concentrations of metal additive of ions of silver (Ag) R148 and S254 in 1% and 2% have been studied and manufactured. The materials are developed on an industrial scale through a process that proceeds as follows: (I) a mixture of polymer and additive in a double-screw compounder to obtain the compound in different concentrations, (II) the manufacture of filaments with a single-screw extruder, (III) 3D printing parts. Therefore, materials are evaluated in the form of powder, pellets and printed pieces to ensure their antibacterial effectiveness throughout the manufacturing process. The results of the research show antibacterial effectiveness for E. coli and Listeria monocytogenes of metal additives and polymeric compounds for all manufacturing phases on an industrial scale, with the effectiveness for additive R148 predominating at a concentration of 2%, demonstrating its microbial efficacy on surfaces with potential application in medicine.

Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease.

The alteration of the endocannabinoid tone usually associates with changes in the expression and/or function of the cannabinoid CB1 receptor. In Alzheimer's disease (AD), amyloid beta (Aß)-containing aggregates induce a chronic inflammatory response leading to reactivity of both microglia and astrocytes. However, how this glial response impacts on the glial CB1 receptor expression in the subiculum of a mouse model of AD, a brain region particularly affected by large accumulation of plaques and concomitant subcellular changes in microglia and astrocytes, is unknown. The CB1 receptor localization in both glial cells was investigated in the subiculum of male 5xFAD/CB2 EGFP/f/f (AD model) and CB2 EGFP/f/f mice by immuno-electron microscopy. The findings revealed that glial CB1 receptors suffer remarkable changes in the AD mouse. Thus, CB1 receptor expression increases in reactive microglia in 5xFAD/CB2 EGFP/f/f , but remains constant in astrocytes with CB1 receptor labeling rising proportionally to the perimeter of the reactive astrocytes. Not least, the CB1 receptor localization in microglial processes in the subiculum of controls and closely surrounding amyloid plaques and dystrophic neurites of the AD model, supports previous suggestions of the presence of the CB1 receptor in microglia. These findings on the correlation between glial reactivity and the CB1 receptor expression in microglial cells and astrocytes, contribute to the understanding of the role of the endocannabinoid system in the pathophysiology of Alzheimer's disease.

Demandas de autocuidado no parto na água: estudo qualitativo / Demandas de autocuidado en el parto en el agua: estudio cualitativo / Self-care demands in water birth: a qualitative study

Resumo Objetivo Analisar a compreensão de puérperas sobre a participação da enfermeira obstetra/obstetriz no parto na água, sob a luz da teoria do autocuidado. Métodos Estudo qualitativo por meio da técnica de análise de conteúdo com a participação de 21 mulheres portuguesas que tiveram o seu parto na água, em ambiente hospitalar. Foi utilizado, como referencial teórico o conceito de autocuidado, proposto por Dorothea Orem. Resultados Aflorou uma grande categoria "Necessidade de Autocuidado no Contexto do Parto na Água", cujas unidades de significados foram: Medo de não conseguir vivenciar o parto na água, Percepção do manejo seguro da distócia, Deconhecimento sobre a gravidade que constitui a hemorragia pós-parto e Incompetência no reparo de traumas perineais. Conclusão As participantes identificaram que a presença da enfermeira obstetra/obstetriz, trouxe segurança para que prosseguissem confiantes no modelo de parto na água. As necessidades das mulheres foram atendidas com respeito permanente pelas profissionais, o que favoreceu a autonomia das puérperas, a harmonia entre as partes e o suporte da enfermeira.

Resumen Objetivo Analizar la comprensión de puérperas sobre la participación de la enfermera obstetra/partera en el parto en el agua, bajo la perspectiva de la teoría del autocuidado. Métodos Estudio cualitativo por medio de la técnica de análisis de contenido, con la participación de 21 mujeres portuguesas que tuvieron su parto en el agua, en ambiente hospitalario. Se utilizó el concepto de autocuidado propuesto por Dorothea Orem como marco referencial teórico. Resultados Surgió una gran categoría "Necesidades de autocuidado en el contexto del parto en el agua", cuyas unidades de significado fueron: Miedo de no poder realizar el parto en el agua, Percepción del manejo seguro de la distocia, Desconocimiento sobre la gravedad que constituye la hemorragia posparto e Incompetencia en la reparación de traumas perineales. Conclusión Las participantes identificaron que la presencia de la enfermera obstetra/partera les dio seguridad para continuar con confianza con el modelo de parto en el agua. Las necesidades de las mujeres fueron atendidas con respeto permanente por parte de las profesionales, lo que favoreció la autonomía de las puérperas, la armonía entre las partes y el apoyo de la enfermera.

Abstract Objective To analyze the puerperal women's understanding about the participation of obstetric nurses/nurse-midwives in water birth, under the light of the Self-Care Deficit Theory. Methods This is a qualitative study using the content analysis technique with the participation of 21 Portuguese women who had water birth at a hospital. The concept of self-care proposed by Dorothea Orem was used as a theoretical framework. Results The mean category "Need for self-care in the context of water birth" emerged, whose meaning units were: Fear of not being able to experience water birth; Perception of dystocia safe management; Lack of knowledge about the severity of postpartum hemorrhage; and Incompetence in perineal trauma repair. Conclusion Participants identified that the presence of obstetric nurses/nurse-midwives brought security for them to continue confident in the water birth model. Women's needs were met with permanent respect by professionals, which favored puerperal women's autonomy, harmony between parties and support by nurses.

Effect of High-Pressure Treatments on the Properties of Food Packaging Materials with or without Antimicrobials.

The aim of this research work was the comparative study of the different properties of interest in the case of plastic materials for food use before and after being subjected to treatment by high hydrostatic pressure (HHP) as well as the impact of additivation with antimicrobials. This method of food preservation is currently on the rise and is of great interest because it is possible to extend the shelf life of many foods without the need for the use of additives or thermal processing, as is the case with other preservation methods currently used. The effects of HHP treatment (680 MPa for 8 min) on plastic materials commonly used in the food industry were studied. These materials, in sheet or film form, were polyethylene (PE), polyethylene terephthalate (PET), polystyrene (PS), multilayer polyethylene terephthalate-ethylene-vinyl alcohol copolymer-polyethylene (PET-EVOH-PE), multilayer polyethylene-polyethylene terephthalate (PE-PET), polyvinyl chloride aluminum (PVC-AL), and polylactic acid (PLA), which were provided by manufacturing companies in the sector. PE, PP, and PLA activated with tyrosol, zinc oxide, or zinc acetate were also tested. The phenomena and properties, such as overall migration, thermal behavior, oxygen barrier, and physical properties were analyzed before and after the process. The results show that the HHP process only slightly affected the properties of the materials. After pressurization, oxygen permeability increased greatly in PVC-AL (from 7.69 to 51.90) and decreased in PLA (from 8.77 to 3.60). The additivation of the materials caused a change in color and an increase in oxygen permeability. The additivated PE and PP showed migration values above the legal limit for certain simulants. The HHP treatment did not greatly affect the mechanical properties of the additivated materials. The main increases in the migration after HHP treatment were observed for PE activated with tyrosol or zinc oxide and for PS activated with zinc oxide. Activated PLA performed the best in the migration studies, irrespective of the HHP treatment. The results suggest that activated PLA could be used in HHP food processing as an inner antimicrobial layer in contact with the food packed in a container with the desired oxygen permeability barrier.

Perceção das mulheres sobre os cuidados recebidos durante o parto na água / Women's perceptions of the care received during water birth / Percepción de las mujeres sobre la atención recibida durante el parto en el agua

Resumo Enquadramento: O modelo de cuidados prestados durante o parto na água é interpessoal, integral e respeitado. Objetivo: Conhecer a perceção das mulheres sobre os cuidados recebidos pelas enfermeiras especialistas de saúde materna e obstétrica durante o parto na água na perspetiva da teoria de enfermagem de Jean Watson. Metodologia: Investigação empírica, qualitativa, interpretativa com 24 mulheres portuguesas que vivenciaram o parto na água no hospital ou no domicílio, com tratamento dos dados baseados no método de análise de conteúdo de Bardin. Resultados: A partir das narrativas, emergiram cinco categorias - ambiente acolhedor; a mulher no controlo do seu próprio parto; relação de confiança; expectativas correspondidas e o companheiro como parte do processo. Conclusão: O Processo Clinical Caritas foi percebido nas narrativas através do respeito e do carinho durante os cuidados prestados, proporcionando uma relação e cooperação, que promoveu posteriormente uma cura interior através desse processo de cuidados. A perceção das participantes do estudo quanto aos cuidados recebidos revelou um ambiente seguro, íntimo, respeitado, acolhedor, sem intervenções desnecessárias, favorável e amparado pelo companheiro.

Abstract Background: The model for care provided during water birth is interpersonal, comprehensive, and respected. Objective: To identify women's perceptions of the care provided by nurses specialized in maternal and obstetric health nursing nurses specialized in maternal and obstetric health nursing during water birth from the perspective of Jean Watson's nursing theory. Methodology: Empirical, qualitative, and interpretative research with 24 Portuguese women who had a water birth in hospitals or at home. Data were analyzed using Bardin's content analysis method. Results: Five categories emerged from the narratives: welcoming environment; women in control during labor; trusting relationship; expectations fulfilled; and the partner as part of the process. Conclusion: The Clinical Caritas Process was perceived in the narratives through respect and affection during care delivery to develop a relationship and promote cooperation, leading to inner healing through this care process. Participants' perceptions of the care received during their water birth revealed a safe, intimate, respectful, welcoming, and favorable environment, without unnecessary interventions and supported by the partner.

Resumen Marco contextual: El modelo de atención al parto en el agua es interpersonal, integral y respetado. Objetivo: Conocer la percepción de las mujeres sobre la atención recibida por las enfermeras especializadas en salud materna y obstetricia durante el parto en el agua desde la perspectiva de la teoría de la enfermería de Jean Watson. Metodología: Investigación empírica, cualitativa e interpretativa con 24 mujeres portuguesas que tuvieron un parto en el agua en el hospital o en casa, con un tratamiento de datos basado en el método de análisis de contenido de Bardin. Resultados: De las narrativas surgieron cinco categorías, ambiente acogedor; la mujer en el control de su propio parto; relación de confianza; expectativas cumplidas y la pareja como parte del proceso. Conclusión: El Proceso Clinical Caritas fue percibido en las narrativas a través del respeto y el afecto durante la atención prestada, lo que proporcionó una relación y cooperación, que posteriormente promovió una curación interior a través de este proceso de atención. La percepción de las participantes en el estudio sobre la atención recibida mostró un ambiente seguro, íntimo, respetuoso, acogedor, sin intervenciones innecesarias, favorable y apoyado por la pareja.

Body composition as a predictor of chemotherapy-related toxicity in ovarian cancer patients: A systematic review.

Objectives: The main objective of this systematic review was to examine the literature evaluating association of image-based body composition with chemotherapy-related toxicity in ovarian cancer patients. A secondary objective was to evaluate the different definitions of sarcopenia across studies. Methods: This systematic review was conducted according to the PRISMA-DTA statement and the protocol was registered on Prospero. A comprehensive literature search of 3 electronic databases was performed by two authors. For each eligible article, information was collected concerning the clinical setting; basic study data; population characteristics; technical aspects; body composition features; chemotherapy drugs administered; association of body composition values and toxicities. The overall quality of the included studies was critically evaluated. Results: After the initial retrieval of 812 articles, the systematic review included 6 articles (5/6 studies were retrospective; one was prospective). The number of patients ranged between 69 and 239; mean/median age ranged between 55 and 65 years; the percentage of sarcopenic patients ranged between 25% and 54%. The cut-off values to define sarcopenia and the vertebral levels for evaluation of body composition were different. Five studies included chemotherapy based on carboplatin and paclitaxel, 1 included chemotherapy based on pegylated liposomal doxorubicin. Among the studies including carboplatin and paclitaxel, 3/5 demonstrated an association with toxicity, whereas 2/5 did not. Altogether, 4/6 papers demonstrated an association between the body composition values and the development of chemotherapy-related toxicities. Conclusions: There is a wide variability of results about the association of body composition and chemotherapy-related toxicity in ovarian cancer patients. Therefore further studies, possibly including a comprehensive assessment of body compartments and where the definition of body composition cut-offs is constant, are warranted to better understand this association. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337753, identifier (CRD42022337753).

Advancing antibody-drug conjugates in gynecological malignancies: myth or reality?

Antibody-drug conjugates (ADCs) represent a new class of therapeutic agents designed to target specific antigens on tumor cells, combining the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents. These drugs have been extensively studied both in solid and hematologic malignancies, leading to substantial improvement in the therapeutic landscape for several tumors. Despite no ADC have been yet approved for the treatment of gynecological malignancies, some agents have shown promising results and might have the potential to become part of the standard of care. Among them, mirvetuximab soravtansine has shown activity in platinum-resistant ovarian cancer with high folate-α receptor expression, as a single agent and in combination. Tisotumab vedotin is active in patients with pre-treated cervical cancer, and further investigation is ongoing. The purpose of this review is to summarize the structural and functional characteristics of ADCs and analyze the most recent and promising data regarding the clinical development of ADCs in gynecological malignancies. The available data on the efficacy of the more studied ADCs in ovarian, endometrial, and cervical cancers will be discussed along with toxicities of special interest, the mechanisms of resistance, and future possible drugs combination.

Face Mask Wastes as Cementitious Materials: A Possible Solution to a Big Concern.

After more than two years wearing surgical masks due to the COVID-19 pandemic, used masks have become a significant risk for ecosystems, as they are producing wastes in huge amounts. They are a potential source of disturbance by themselves and as microplastic contamination in the water system. As 5500 tons of face masks are estimated to be used each year, there is an urgent need to manage them according to the circular economy principles and avoid their inadequate disposal. In this paper, surgical wear masks (WM), without any further pretreatment, have been introduced as addition to mortars up to 5% in the weight of cement. Mechanical and microstructural characterization have been carried out. The results indicate that adding MW to the cement supposes a decrease in the properties of the material, concerning both strength and durability behavior. However, even adding a 5% of WM in weight of cement, the aspect of the mortars is quite good, the flexural strength is not significantly affected, and the strength and durability parameters are maintained at levels that-even lower than the reference-are quite reasonable for use. Provided that the worldwide production of cement is around 4.1 Bt/year, the introduction of a 5% of WM in less than 1% of the cement produced, would make it possible to get rid of the mask waste being produced.

Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders.

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation. Approximately one-third of patients may present mild symptoms and remain stable under supportive care. The remaining patients may develop severe multiorgan autoimmunity requiring lifelong immunosuppressive treatment. Hematopoietic stem cell transplantation (HSCT) is potentially curable for patients with treatment-resistant immune dysregulation. Nevertheless, little experience is reported regarding the management of complications post-HSCT. We present case 1 (CTLA-4 haploinsufficiency) and case 2 (CTLA-4 insufficiency-like phenotype) manifesting with severe autoimmunity including cytopenia and involvement of the central nervous system (CNS), lung, and gut and variable impairment of humoral responses. Both patients underwent HSCT for which the main complications were persistent mixed chimerism, infections, and immune-mediated complications [graft-versus-host disease (GVHD) and nodular lung disease]. Detailed management and outcomes of therapeutic interventions post-HSCT are discussed. Concretely, post-HSCT abatacept and human leukocyte antigen (HLA)-matched sibling donor lymphocyte infusions may be used to increase T-cell donor chimerism with the aim of correcting the immune phenotype of CTLA-4 haploinsufficiency.

Osteoblastoma of the Lumbar Spine: Findings in SPECT/CT.

ABSTRACT: Osteoblastoma is an uncommon benign osteoid tissue-forming bone tumor. We present the case of a 16-year-old adolescent boy with lower back pain that radiated down the right thigh. Lumbar MRI and CT findings were consistent with a long-standing osteoid osteoma located in the right laminae and pedicle of L3. SPECT/CT with 99mTc-DPD showed a highly increased osteogenic activity within the lesion, especially in the core region, also suggesting an osteoid osteoma. Surgical en bloc resection was performed with a final histological diagnosis of osteoblastoma.

Adaptación transcultural de un cuestionario de alimentación para niños de edad escolar en Córdoba, Argentina / Cross-cultural adaptation of a food questionnaire for schoolchildren in Córdoba, Argentina

Fundamentos: La evaluación de la ingesta en la niñez requiere instrumentos adecuados para la edad. Elobjetivo fue adaptar transculturalmente un cuestionario de alimentación para escolares desarrollado en Brasil(QUADA) y analizar su confiabilidad y validez para su aplicación en Córdoba, Argentina Métodos: El QUADA fue traducido al español y se reemplazaron las ilustraciones por alimentosrepresentativos localmente. Se realizaron pruebas de comprensión para evaluar interpretación de consignas eilustraciones y realizar modificaciones hasta llegar al cuestionario final: CuAE-24. Se evaluó la fiabilidad testretest aplicando el CuAE-24 dos veces el mismo día en una muestra de 113 escolares y se analizó la concordancia entre ambas aplicaciones usando test de Kappa. La validez se evaluó mediante la observación de la comida escolar (“gold standard”) el día anterior a la aplicación del CuAE-24, que fue contrastada con lasrespuestas de los escolares. Se calculó sensibilidad, especificidad, valores predictivos positivos (VPP) y negativos (VPN). Resultados: El CuAE-24 presenta 5 secciones (desayuno, media-mañana, comida, merienda, cena), con 76 alimentos ilustrados agrupados en 24 ítems. El test-retest presentó adecuada concordancia y se hallaron valores de sensibilidad, especificidad, VPP y VPN aceptables. Conclusiones: El CuAE-24 presenta validez y confiabilidad satisfactorias para utilizarse en investigaciones epidemiológicas en escolares de Córdoba, Argentina. (AU)

Background: Food intake assessment in childhood requires age-appropriate instruments. The objective was to analyze the cross-culturally adapt a food questionnaire for schoolchildren developed in Brazil (QUADA) andanalyze its reliability and validity for its application in Córdoba, Argentina.Methods: The QUADA was translated into Spanish and the illustrations were replaced by locally representative foods. Comprehension tests was carried out to evaluate interpretation of instructions and illustrations and to make modifications until reaching the final questionnaire: CuAE-24. To evaluate the testretest reliability, the CuAE-24 was applied twice the same day, in a sample of 113 schoolchildren. The Kappa test was used to analyze the concordance between both applications. The validity was analyzed by observing the school lunch (“gold standard”) the day before the application of the CuAE-24, which was contrasted with the responses of the schoolchildren. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were calculated.Results: The CuAE-24 presents 5 sections (breakfast, mid-morning, lunch, snack, dinner), with 76 illustrated foods grouped into 24 items. The test-retest presented adequate concordance and acceptable sensitivity, specificity, PPV and NPV values were found in most of the items. Conclusions: The CuAE-24 presents satisfactory validity and reliability to be used in epidemiologicalresearches in schoolchildren in Córdoba, Argentina. (AU)

Computed Tomography-Based Body Composition in Patients With Ovarian Cancer: Association With Chemotoxicity and Prognosis.

PURPOSE: To assess the association between computed tomography (CT)-derived quantitative measures of body composition profiling and chemotherapy-related complications, in terms of dose reduction, premature discontinuation of chemotherapy, and cycle delays in patients with ovarian cancer. Secondary purposes were to evaluate associations between sarcopenia and survival, and to evaluate differences in body composition profiling at baseline and after neoadjuvant chemotherapy. MATERIALS AND METHODS: The study population was retrospectively selected from a database of patients with newly diagnosed ovarian cancer (any stage) referred to our Institution between Feb 2011 and Mar 2020. Clinical data were recorded, and CT images at the level of the 3rd lumbar vertebra were stored. By using specific software, skeletal muscle area (SMA), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and skeletal muscle density (SMD) were extracted. Skeletal muscle index (SMI) was then calculated. Statistical analysis was performed by logistic regression models to identify body composition features predictive of dose reduction, premature end of chemotherapy, and cycle delays. Kaplan-Meier analyses were performed to assess overall survival (OS) and progression-free survival (PFS). The log-rank test was used to determine differences in OS and PFS between sarcopenic and non-sarcopenic patients. Wilcoxon test was performed to compare body composition features before and after neoadjuvant chemotherapy (NACT). RESULTS: Sixty-nine patients were included. A significant association was found between VAT and cycle delays (OR = 1.01, z = 2.01, 95% CI: 1.00-1.02, p < 0.05), between SMA and early discontinuation of chemotherapy (OR = 1.03, z = 2.10, 95% CI: 1.00-1.05, p < 0.05), and between mean SMD and cycle delays (OR = 0.92, z = -2.70, 95%CI: 0.87-0.98, p < 0.01). No significant difference emerged for OS in sarcopenic and non-sarcopenic patients, nor in CT body composition features before and after NACT. CONCLUSIONS: In ovarian cancer patients, CT-derived body composition profiling might predict the risk of chemotoxicity. In particular, VAT and SMD are associated with chemotherapy cycle delays, and SMA with early discontinuation of chemotherapy.

Breast Carcinomatous Lymphangitis as an Unusual Presentation of Ovarian Cancer.

We describe the case of a 45-year-old woman with an unusual presentation of metastatic ovarian cancer. The patient presented to the oncological clinic with a three-week history of skin rash on the right breast. She underwent a chest and abdomen CT scan, which showed skin thickening of the right breast, right pleural effusion and bilateral cystic ovarian masses. Biopsy of a left ovarian lesion by diagnostic laparoscopy revealed the presence of ovarian serous carcinoma. Biopsy of the breast skin lesion revealed the presence of carcinomatous lymphangitis and immunohistochemistry documented the ovarian origin.