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Bioanalysis ; 16(9): 415-427, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38497729

RESUMO

Background: Fingerprint drug concentrations can be used as a noninvasive and convenient alternative to evaluate adherence to pharmacotherapy. Methods: Fingerprints were applied over glass slides, extracted and analyzed by ultra-high performance LC-MS/MS. The assay and drug adherence questionnaires were applied to 30 epilepsy patients. Results: The assay had linearity in the range 0.05-10 ng fingerprint-1, with precision of 2.16-7.9% and accuracy of 95.0-102.8%. Carbamazepine (CBZ) levels in fingerprints were stable at 45°C for 15 days. Concentrations in patient samples were 0.06-9.28 ng fingerprint-1. A significant difference (p = 0.003) was found between CBZ concentrations in fingerprints between patient groups divided as low and medium/high adherence. Conclusion: This method can potentially be applied to the identification of epilepsy patients with low adherence to CBZ pharmacotherapy.


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Assuntos
Carbamazepina , Epilepsia , Estudos de Viabilidade , Adesão à Medicação , Espectrometria de Massas em Tandem , Carbamazepina/uso terapêutico , Humanos , Epilepsia/tratamento farmacológico , Feminino , Masculino , Espectrometria de Massas em Tandem/métodos , Adulto , Anticonvulsivantes/uso terapêutico , Cromatografia Líquida de Alta Pressão/métodos , Dermatoglifia , Pessoa de Meia-Idade , Adulto Jovem
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