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1.
Analyst ; 147(7): 1515, 2022 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-35244659

RESUMO

Correction for 'Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection' by Imesha W. De Silva et al., Analyst, 2020, 145, 5725-5732, DOI: 10.1039/D0AN01074J.

2.
Analyst ; 145(17): 5725-5732, 2020 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-32696763

RESUMO

The SARS-CoV-2 virus is known as the causal agent for the current COVID-19 global pandemic. The majority of COVID-19 patients develop acute respiratory distress syndrome (ARDS), while some experience a cytokine storm effect, which is considered as one of the leading causes of patient mortality. Lipids are known to be involved in the various stages of the lifecycle of a virus functioning as receptors or co-receptors that controls viral propagation inside the host cell. Therefore, lipid-related metabolomics aims to provide insight into the immune response of the novel coronavirus. Our study has focused on determination of the potential metabolomic biomarkers utilizing a Teslin® Substrate in paper spray mass spectrometry (PS-MS) for the development of a rapid detection test within 60 seconds of analysis time. In this study, results were correlated with PCR tests to reflect that the systemic responses of the cells were affected by the COVID-19 virus.


Assuntos
Infecções por Coronavirus/patologia , Metabolismo dos Lipídeos/fisiologia , Espectrometria de Massas/métodos , Pneumonia Viral/patologia , Betacoronavirus/isolamento & purificação , Biomarcadores/metabolismo , COVID-19 , Infecções por Coronavirus/metabolismo , Infecções por Coronavirus/virologia , Análise Discriminante , Humanos , Lipídeos/análise , Nasofaringe/virologia , Pandemias , Papel , Pneumonia Viral/metabolismo , Pneumonia Viral/virologia , SARS-CoV-2
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