1.
Leuk Res
; 25(6): 501-7, 2001 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11337024
RESUMO
We report a case of acute myeloid leukemia (AML-M2) expressing myeloperoxidase (MPO) but no myeloid antigens. A few cases with this discordant phenotype have been reported and an association has been suggested between the lack of CD13 and CD33 in MPO positive AML and the presence of t(8;21). Cytogenetic and molecular analyses performed in our case showed 48,XY,+Y,+8,t(2;9)(q14;p12). We believe that combined approaches can contribute to detect particular AL cases like the present one, that confirms the heterogeneity of AML. However, further studies are needed to clarify the relationship between phenotypic aberrations and cytogenetic abnormalities.
Assuntos
Cromossomos Humanos Par 2 , Cromossomos Humanos Par 9 , Leucemia Mieloide Aguda/genética , Peroxidase/metabolismo , Translocação Genética , Adulto , Idoso , Antígenos CD/análise , Antígenos de Diferenciação Mielomonocítica/análise , Antígenos CD13/análise , Criança , Humanos , Leucemia Mieloide Aguda/enzimologia , Leucemia Mieloide Aguda/imunologia , Pessoa de Meia-Idade , Lectina 3 Semelhante a Ig de Ligação ao Ácido Siálico
2.
Br J Haematol
; 101(2): 394-6, 1998 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9609544