[Changes in the activity of gamma-glutamyltransferase and cholinesterase in the blood of patients with opisthorchiasis at different phases of the disease]. / Izmeneniia aktivnosti gamma-glutamiltransferzay i kholinésterazy v krovi bol'nykh opistorkhozom v razlichnykh fazakh zabolevaniia.

The plasma activity of gamma-glutamyl transferase (GGT) and cholinesterase (CE) was assayed in 79 patients with opisthorchiasis in its active and chronic periods, as well in different periods after anthelminthic therapy with biltricide and azinox. The mean values of CE activity did not significantly differ between the groups of the examinees. The probability of decreased CE synthesis in the residual period was significantly greater in the treatment of chronic than acute opisthorchiasis. The maximum activity of GGT was found in acute opisthorchiasis, its values were also significantly higher than the control ones and remained unchanged within a year after anthelminthic therapy. Possible causes of delayed normalization of enzymatic activity following the treatment of chronic versus acute opisthorchiasis are discussed in the paper.

[Studies on the heterogeneity of blood serum high-molecular fraction proteins in healthy people and patients with cancer]. / Vivchennia geterogennosti bilikiv visokomolekuliarnoi fraktsii sirovatki krovi zdorovikh liudei ta khvorikh na rak.

Heterogeneity of proteins of blood serum high-molecular fraction in healthy people, patients with cancer and those with pathologies of nonmalignant nature was studied by the method of disc electrophoresis in 4% polyacrylamide gel. It is established that under conditions of the experiment sharp differences are observed in heterogeneity of studied proteins manifesting in a growth of the discrete electrophoretic bands in disc electrophoregrams of high-molecular fractions of sera from the cancer patients. Disc electrophoregrams of proteins of the studied fractions from the sera of patients with nonmalignant pathologies also differ from those of control groups, though not so sharply as when comparing the preparations obtained from the sera of healthy people and cancer patients. Possible reasons of the observed differences are discussed.