1.
Bioorg Med Chem Lett
; 13(3): 343-6, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12565926
RESUMO
3 alpha-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 microM concentration 4 significantly increased GABA induced (36)Cl(-) influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid.