[The efficacy of bacteriophage preparations in treating inflammatory urologic diseases]. / Effektivnost' preparatov bakteriofagov pri lechenii vospalitel'nykh urologicheskikh zabolevanii.

Urinary infection is the most commonly encountered hospital infection. Antibacterial therapy promotes selection and dissemination of polyresistant microorganism strains, development of intestinal dysbacteriosis, reduction of intestinal contamination resistance. Clinical and bacteriological efficacy of urinary infection treatment with bacteriophage preparations (pyocyanic, proteus, staphylococcal, coliphage, combined pyobacteriophage) was studied. Sensitivity of the infective agent phage isolated from urological patients was tested before treatment. The preparations were adapted to recently isolated agents from urological patients to raise phage sensitivity of the strains. A total of 293 strains were studied. Phage sensitivity made up 68.9%. Bacteriophage preparations were used both locally and orally in 46 patients with acute and chronic urogenital inflammation. Bacteriological efficacy amounted to 84%, clinical one to 92%. It is inferred that phagotherapy is effective and safe therapeutic modality in the treatment of urinary infection in monotherapy and in combination with antibiotics.

[The use of cephmetazon in treating infectious inflammatory diseases of the upper and lower urinary tract]. / Primenenie tsefmetazona pri lechenii infektsionno-vospalitel'nykh zabolevanii verkhnikh i nizhnikh mochevyvodiashchikh putei.

A clinical trial of cephmethasone (Sankyo, Japan) has been performed in 40 patients with pyelonephritis. 3 patients with chronic cystitis. 19 patients with chronic prostatitis. Cephmethasone, cephalosporin of the second generation, is active against gram-positive and gram-negative agents, hospital infection. The treatment course consists of 4-14 daily doses of 2-4 g. Bacterial elimination was reached in 79.5% of the cases with a complete response in 70% and partial one in 30% of patients. Side effects were not registered. As a highly active wide-spectrum antibiotic, cephmethasone is offered for treatment of urinary infections. Cephmethasone monotherapy provides a rapid relief of cystitis, prostatitis and pyelonephritis symptoms.

[The conditions for performing extracorporeal lithotripsy with different physicochemical compositions of the urinary stones]. / Usloviia provedeniia distantsionnoi litotripsii pri razlichnom fiziko-khimicheskom sostave mochevykh kamnei.

Remote impulse lithotripsy (RIL) parameters were assessed when crushing uroliths with the use of URAT-II lithotriptor. The results were referred to the concrement size, location and physicochemical properties. A total of 365 examinations were made. Disintegration of large concrements, including coral calculi occurred in response to less number of impulses than it was necessary for destruction of concrements up to 1.5 cm in size. The hardest were vitlokite and cystine stones. The lowest traumaticity was observed in disintegration of the concrements composed of struvite and carbonatapatite.

[The determination of the chemiluminescence of stimulated blood leukocytes in assessing the activity of chronic pyelonephritis]. / Opredelenie khemiliuminestsentsii stimulirovannykh leikotsitov krovi v otsenke aktivnosti khronicheskogo pielonefrita.

The activity of oxidant metabolism was studied in leukocytes from the whole blood of 23 patients diagnosed to have urolithiasis, chronic pyelonephritis in remission. Leukocyte function was evaluated by registration of luminol-dependent chemiluminescence. Barium sulfate microcrystals served leukocyte stimulator. Chemiluminescence was registered by chemiluminometer NPA-02. Diagnostic implication of chemiluminescence and other clinical-laboratory parameters was derived from the equations of multiple linear regression arranged in a model. It is shown possible to significantly assess chronic inflammation activity in renal tissue by whole blood chemiluminescence and ESR. Low functional activity of neutrophils recorded by chemiluminescence may indicate chronicity of renal tissue inflammation.

[The clinical efficacy of the new drug agent ligentén in urology patients]. / Klinicheskaia éffektivnost' novogo lekarstvennogo sredstva ligenténa u urologicheskikh bol'nykh.

A clinical trial was made of a new gel ligenten intended for local urethral anesthesia and treatment of infection and inflammation in the lower urinary tracts. Ligenten was given to 52 patients to manage bladder, prostate, urethral infection and inflammation, for local prophylaxis before cystoscopy, urethral bouginage and transurethral surgery. Apparent advantages of intraurethral introduction of the analgetic compared to instrument lubrication are demonstrated. Ligenten was also effective against chronic cystitis, cystalgia and urethral syndrome in females, especially in ulcerative cystitis. The gel exhibited adequate antiinflammatory and analgetic effect. As a prophylactic means, it prevents inflammation in cystoscopy, urethral catheterization and transurethral operations. No severe side effects have been reported.

[The efficacy of Ligenten gel in the prevention and treatment of infectious-inflammatory diseases of the urogenital organs]. / Effektivnost' gelia Ligentena pri profilaktike i lecheniia infektsionno-vospalitel'nykh zabolevanii mochepolovykh organov.

A new therapeutic in the form of a gel named ligenten was studied. The gel active components are lidocain, gentamicin and ethonium. Ligenten was shown to have a marked local anesthetic action when administered transurethrally. As a prophylactic agent the gel was highly active against the majority of the causative agents of renal infections due to cystoscopy, catheterization and bougienage of the urethra. Ligenten provided a sufficient anesthetic effect in transurethral operations but did not prevent superinfection due to the hospital strains. Marked antiinflammatory and reparative actions of the gel especially in the treatment of ulcerous cystitis were observed.

[Urinary enzymes induced in rats by intensive physical loading and the effect of the antioxidant potassium fenozan]. / Fermenturiia, vyzvannaia u krys intensivnoi fizicheskoi nagruzkoi, i vliianie na nee antioksidanta fenozana kaliia.

The rats subjected to repeated heavy exercises (swimming with the load equal to 10% of body weight) had an increased activity of gamma-glutamyl transpeptidase in the urine. Both the percentage of the rats with hyperenzymuria and the level of enzyme were the highest after the fifth swimming. Water-soluble antioxidant (potassium fenozan) administered intraperitoneally 30 minutes before the swimming abolished the increase of enzymuria and maintained the enzyme activity to the normal level.

[Determination of the composition of the concretions in patients with nephrolithiasis by metabolic indices]. / Opredelenie sostava konkrementov u bol'nykh nefrolitiazom po metabolicheskim pokazateliam.

The authors considered an important problem of in vivo verification of urolith composition as specifying the choice of drug treatment and prevention of urolithiasis. 84 nephrolithiasis patients were allocated to 4 groups according to their concrement compositions (after spontaneous or surgical removal): 23 patients with urate calculus, 19 with oxalate, 20 with phosphate and 22 with oxalate-phosphate concrements. Polarizing microscopy, x-ray structural analysis and infrared spectrophotometry were employed for verification of calculi composition. Biochemical assay was used for the assessment of serum and circadian excretion of calcium, phosphates, sodium, potassium, uric acid, oxalates and uroacidimetric values. The findings were subjected to discriminant computed analysis which resulted in 6 linear computable functions defining 4 selective groups with regard to biochemical blood and urine data. The aforementioned functions were used in diagnostic routine for the in vivo assessment of calculous composition in 26 controls. In 61.5 per cent of the patients the diagnosis was confirmed, in 34.6 per cent it was verified, and only in 3.9 per cent the diagnosis turned to be erroneous.