RESUMO
Over the last years, there has been an enormous increase in the knowledge on koi herpesvirus (KHV), koi herpesvirus disease (KHVD), pathogenesis and virus variants. Different KHV lineages have clearly been identified, possible genomic changes during replication in different cell cultures at different temperatures but also in several hosts have been identified, a persistent stage of infection has been specified and it has been shown that infection with KHV is not host specific at all, but KHVD is. Additionally, it has been shown that it is possible to combat KHVD by immunization with inactivated and attenuated live vaccines using different delivery systems but also to benefit from alternative treatments with e.g. exopolysaccharids obtained from Arthrospira platensis.
Assuntos
Carpas/virologia , Doenças dos Peixes/virologia , Infecções por Herpesviridae/veterinária , Herpesviridae/fisiologia , Animais , Aquicultura , Doenças dos Peixes/prevenção & controle , Herpesviridae/classificação , Herpesviridae/genética , Herpesviridae/patogenicidade , Infecções por Herpesviridae/prevenção & controle , Infecções por Herpesviridae/virologia , Especificidade de Hospedeiro , Polissacarídeos Bacterianos/uso terapêutico , Vacinas Atenuadas/uso terapêutico , Vacinas Virais/uso terapêuticoRESUMO
In primary cell preparations from larvae of rainbow trout Oncorhynchus mykiss, the formation of autonomously contracting cell aggregates was observed after 7 days. These contracting elements could be propagated and some aggregates were maintained over a period of 35 days. Electron microscopical and immunocytochemical examination revealed the presence of cardiomyocytes.