RESUMO
OBJECTIVE: To study the chemical constituents of the PTP 1B inhibitory effective parts of Paeoniae Rubra Radix. METHODS: The effective part of Paeoniae Rubra Radix was enriched by Sephadex LH-20. Compounds were isolated by various column chromatography and their structures were elucidated through spectroscopic analysis. RESULTS: Thirteen compounds were identified as: benzoylpaeoniflorin(1), albiflorin(2), paeoniflorigenone(3), methyl gallate(4), adenosine(5),2-amino adenosine(6), 3,3'-Di-O-methylellagic acid(7), 3,3',4-trimethyl ellagic acid(8), dihydrokaempferol(9), glycerol(10), dibutyl phthalate(11). CONCLUSION: Compounds 5-11 are obtained from this plant for the first time.
Assuntos
Adenosina/química , Medicamentos de Ervas Chinesas/química , Ácido Elágico/química , Paeonia/química , Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores , Adenosina/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Ácido Elágico/isolamento & purificação , Inibidores Enzimáticos/química , Inibidores Enzimáticos/isolamento & purificação , Flavonoides/química , Flavonoides/isolamento & purificação , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Raízes de Plantas/químicaRESUMO
OBJECTIVE: To analyse the epidemiological and clinical characteristics of different pathogenesis type cases, severe and common cases of hand, foot and mouth disease. METHODS: Descriptive epidemic method was used to analyse the epidemiological and clinical characteristics of laboratory-confirmed cases with hand,foot and mouth disease. RESULTS: The epidemiological characteristics 113 cases were the same as epidemic situation at the same time in Anji county. Clinical characteristics were difference in different pathogenesis type cases, severe and common cases of hand, foot and mouth disease. CONCLUSION: Prevention and control work taken should according to the characteristics of the disease, such as early identification of severe cases, handling and controlling over the outbreaks in order to reduce the severe cases and the death.