1.
Chem Commun (Camb)
; (21): 2234-5, 2001 Nov 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12240127
RESUMO
Two types of spermine-based gemini surfactants have been synthesised; structure-activity studies have shown one type to be far superior in gene transection than the other.
Assuntos
Técnicas de Transferência de Genes , Espermina/análogos & derivados , Espermina/química , Tensoativos/química , Linhagem Celular , DNA/genética , Relação Estrutura-Atividade , Transfecção
2.
J Med Chem
; 42(23): 4824-35, 1999 Nov 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10579845
RESUMO
myo-Inositol 1,4,5-tris(phosphate) was modified at position 6. The analogues synthesized are reported in this publication are 6-deoxy-myo-inositol 1,4,5-tris(phosphate), 6-fluoro-6-deoxy-myo-inositol 1,4,5-tris(phosphate), epi-inositol 1, 4,5-tris(phosphate), and 6-amino-6-deoxy-myo-inositol 1,4, 5-tris(phosphate). These derivatives showed poor affinity for the Ins(1,4,5)P(3) receptors. The inframolecular acid-base behavior and the cooperative effects between the phosphate groups could help explain the loss of affinity of these 6-modified analogues.
