Sociocultural and contextual determinants of science career goal at a community college and baccalaureate-granting institution.

Guided by social cognitive career theory (SCCT; Lent et al. in J Vocat Behav 45(1):79-122, 1994), we assessed sociocultural (e.g., home-school cultural value mismatch) and contextual barriers (e.g., institutional climate) in science education and career development at both a baccalaureate-granting institution (BGI) and community college (CC) among 263 students (72.4% female; Mage = 22.96, SD = 5.70) in the USA. For BGI students, path analyses suggest proximal factors such as in-class prejudice negatively predicted science self-efficacy and prejudice from faculty and staff predicted lower career outcome expectations. For CC students, home-school cultural value mismatch directly predicted science career goals. Implications for future research, intervention and policy are discussed.

Déterminants socioculturels et contextuels dans l'objectif de poursuivre une carrière scientifique dans un collège communautaire et un établissement délivrant le baccalauréat Guidés par la théorie sociale cognitive de la carrière (SCCT; Lent et al., 1994), nous avons évalué les barrières socioculturelles (p. ex. le décalage entre les valeurs culturelles de l'école et de la famille) et contextuelles (par exemple, le climat institutionnel) dans l'enseignement des sciences et le développement de carrière dans un établissement conférant le baccalauréat (BGI) et un collège communautaire (CC) parmi 263 étudiant·e·s (72,4% femmes; Mage = 22,96, SD = 5,70) aux États-Unis. Pour les étudiant·e·s de BGI, les analyses suggèrent que les facteurs proximaux tels que les préjugés dans la classe prédisent négativement l'auto-efficacité scientifique et que les préjugés du corps enseignant et du personnel prédisent des attentes plus faibles en matière de carrière. Pour les étudiants CC, le décalage des valeurs culturelles entre la famille et l'école prédit directement les buts de carrière scientifique. Les implications pour les recherches futures, les interventions et les politiques sont discutées.

Determinantes socioculturales y contextuales de las metas en carreras científicas en un colegio comunitario e instituciones que otorgan grados en bachillerato (103R1) Guiados por la teoría social cognitiva de la carrera (SCCT; Lent et al., 1994), evaluamos las barreras socioculturales (p. ej., el desajuste cultural entre el hogar y la escuela) y las barreras contextuales (p. ej., el clima institucional) en la educación científica y el desarrollo profesional tanto en un bachillerato como en una institución otorgante (BGI) y colegio comunitario (CC) entre 263 estudiantes (72.4% mujeres; Edad = 22.96, SD = 5.70) en los Estados Unidos. Para los estudiantes de BGI, los análisis de ruta sugieren factores proximales como el prejuicio en la clase que predijo negativamente la autoeficacia científica y el prejuicio de la facultad y el personal predijeron expectativas de resultados profesionales más bajas. Para los estudiantes de CC, el desajuste de los valores culturales entre el hogar y la escuela predijo directamente las metas de la carrera científica. Se discuten las implicaciones para futuras investigaciones, intervenciones y políticas.

Nuclear isoform of RAPH1 interacts with FOXQ1 to promote aggressiveness and radioresistance in breast cancer.

Radioresistance limits the efficacy of radiotherapy against breast cancer, especially the most lethal subtype of breast cancer, triple-negative breast cancer (TNBC). Epithelial-to-mesenchymal transition (EMT) is closely related to tumor radioresistance. In this work, we attempted to identify the key EMT-related transcription factor(s) that can induce radioresistance in breast cancer cells. A set of 44 EMT transcription factors were analyzed in parental and radioresistant TNBC cell lines. The function of FOXQ1, a differentially expressed transcription factor, was determined in TNBC radioresistance. FOXQ1-interacting proteins were identified by co-immunoprecipitation and mass spectrometry. Compared with parental cells, FOXQ1 was significantly upregulated in radioresistant TNBC cells. Silencing of FOXQ1 increased the radiosensitiviy of radioresistant TNBC cells both in vitro and in vivo. FOXQ1 associated with a nuclear isoform of RAPH1 (named RAPH1-i3) in radioresistant TNBC cells. Overexpression of RAPH1-i3 enhanced TNBC cell proliferation and migration, and most interestingly, induced radioresistance in parental TNBC cells when co-expressed with FOXQ1. Similar findings were observed in estrogen receptor-positive breast cancer cell lines that had co-expression of RAPH1-i3 and FOXQ1. Mechanistically, co-expression of RAPH1-i3 and FOXQ1 activated STAT3 signaling and increased the expression of CCND1, MCL1, Bcl-XL, and MMP2. Depletion of RAPH1-i3 impaired the radioresistance of radioresistant TNBC cells. Additionally, RAPH1-i3 upregulation was associated with advanced tumor stage and reduced disease-free survival in TNBC patients. These results collectively show that RAPH1-i3 interacts with FOXQ1 to promote breast cancer progression and radioresistance. RAPH1-i3 and FOXQ1 represent therapeutic targets for the treatment of breast cancer including TNBC.

Functional analysis of transgenic cry1Ah-1 maize.

Maize is an important food crop in the world, but the yield and quality of maize have been significantly reduced due to the impact of insect pests. In order to address this issue, the cry1Ah gene was subjected to error-prone PCR for mutagenesis, and subsequently, the mutant cry1Ah-1 gene was introduced into maize inbred line GSH9901 callus using the Agrobacterium-mediated method. The T2 generation transformed plants were obtained by subculture, and 9 transgenic positive plants were obtained by molecular detection which was carried out by PCR, qRT-PCR, Bt gold-labeled immunoassay test strips, Western blot and ELISA. It was found that the Cry1Ah-1 gene could be transcribed normally in maize leaves, of which OE1 and OE3 had higher relative expression levels and could successfully express proteins of 71.94 KD size. They were expressed in different tissues at the 6-leaf stage, heading stage and grain-filling stage, and could ensure the protection of maize from corn borer throughout the growth period. The biological activities of OE1 and OE3 were tested indoors and in the field, and the results showed that in indoors, the corn borer that fed on OE1 and OE3 corn leaves had a mortality rate of 100 % after 3 days; in the field, OE1 and OE3 had strong insecticidal activity against corn borer, reaching a high resistance level. In conclusion, the transgenic cry1Ah-1 maize has a strong insecticidal effect on corn borer, and has a good prospect of commercialization.

Different Sources of Bone Marrow Mesenchymal Stem Cells: A Comparison of Subchondral, Mandibular, and Tibia Bone-derived Mesenchymal Stem Cells.

BACKGROUND: Stem cell properties vary considerably based on the source and tissue site of mesenchymal stem cells (MSCs). The mandibular condyle is a unique kind of craniofacial bone with a special structure and a relatively high remodeling rate. MSCs here may also be unique to address specific physical needs. OBJECTIVE: The aim of this study was to compare the proliferation and multidirectional differentiation potential among MSCs derived from the tibia (TMSCs), mandibular ramus marrow (MMSCs), and condylar subchondral bone (SMSCs) of rats in vitro. METHODS: Cell proliferation and migration were assessed by CCK-8, laser confocal, and cell scratch assays. Histochemical staining and real-time PCR were used to evaluate the multidirectional differentiation potential and DNA methylation and histone deacetylation levels. RESULTS: The proliferation rate and self-renewal capacity of SMSCs were significantly higher than those of MMSCs and TMSCs. Moreover, SMSCs possessed significantly higher mineralization and osteogenic differentiation potential. Dnmt2, Dnmt3b, Hdac6, Hdac7, Hdac9, and Hdac10 may be instrumental in the osteogenesis of SMSCs. In addition, SMSCs are distinct from MMSCs and TMSCs with lower adipogenic differentiation and chondrogenic differentiation potential. The multidirectional differentiation capacities of TMSCs were exactly the opposite of those of SMSCs, and the results of MMSCs were intermediate. CONCLUSION: This research offers a new paradigm in which SMSCs could be a useful source of stem cells for further application in stem cell-based medical therapies due to their strong cell renewal and osteogenic capacity.

Peer-Peer Cultural Value Mismatch in the Dormitory During the Transition to College: Antecedents and Correlates.

This research focuses on peer-peer cultural value mismatch - perceived mismatch between collectivistic ideologies and practices of one student and individualistic ideologies and practices of another - among students living in the dormitories during the transition to college. Two survey studies examined the antecedents and correlates of two types of mismatch: (1) reciprocation mismatch: giving or offering a material or service to one's roommate but not receiving anything in return; and (2) not thinking of the other: feeling as though roommates are not considerate of one's feelings or schedule. Study 1: A sample of 110 students in their first year of college showed that being a first-generation college student increased the likelihood of experiencing reciprocation mismatch. Both forms of mismatch predicted experiences of psychological distress, reports of academic problems, and lower grades. Study 2: A sample of 152 (76 dormitory roommate pairs) first-year college students revealed that social-class differences in parental education between dormitory roommates predicted students' experiences with reciprocation mismatch. Students of lower parental education than their roommate reported significantly more mismatch. More mismatch experience was in turn linked to significantly higher levels of academic problems during the transition to college. Implications for research, residential life, and intervention are discussed.

Intercellular mitochondrial transfer in the brain, a new perspective for targeted treatment of central nervous system diseases.

AIM: Mitochondria is one of the important organelles involved in cell energy metabolism and regulation and also play a key regulatory role in abnormal cell processes such as cell stress, cell damage, and cell canceration. Recent studies have shown that mitochondria can be transferred between cells in different ways and participate in the occurrence and development of many central nervous system diseases. We aim to review the mechanism of mitochondrial transfer in the progress of central nervous system diseases and the possibility of targeted therapy. METHODS: The PubMed databank, the China National Knowledge Infrastructure databank, and Wanfang Data were searched to identify the experiments of intracellular mitochondrial transferrin central nervous system. The focus is on the donors, receptors, transfer pathways, and targeted drugs of mitochondrial transfer. RESULTS: In the central nervous system, neurons, glial cells, immune cells, and tumor cells can transfer mitochondria to each other. Meanwhile, there are many types of mitochondrial transfer, including tunneling nanotubes, extracellular vesicles, receptor cell endocytosis, gap junction channels, and intercellular contact. A variety of stress signals, such as the release of damaged mitochondria, mitochondrial DNA, or other mitochondrial products and the elevation of reactive oxygen species, can trigger the transfer of mitochondria from donor cells to recipient cells. Concurrently, a variety of molecular pathways and related inhibitors can affect mitochondrial intercellular transfer. CONCLUSION: This study reviews the phenomenon of intercellular mitochondrial transfer in the central nervous system and summarizes the corresponding transfer pathways. Finally, we propose targeted pathways and treatment methods that may be used to regulate mitochondrial transfer for the treatment of related diseases.

The driving mechanism and targeting value of mimicry between vascular endothelial cells and tumor cells in tumor progression.

The difficulty and poor prognosis of malignant tumor have always been a difficult problem to be solved. The internal components of solid tumor are complex, including tumor cells, stromal cells and immune cells, which play an important role in tumor proliferation, migration, metastasis and drug resistance. Hence, targeting of only the tumor cells will not likely improve survival. Various studies have reported that tumor cells and endothelial cells have high plasticity, which is reflected in the fact that they can simulate each other's characteristics by endothelial-mesenchymal transition (EndMT) and vasculogenic mimicry (VM). In this paper, this mutual mimicry concept was integrated and reviewed for the first time, and their similarities and implications for tumor development are discussed. At the same time, possible therapeutic methods are proposed to provide new directions and ideas for clinical targeted therapy and immunotherapy of tumor.

Negative perceived context of reception and sociocultural resources on mental health among Hispanic and Somali adolescents.

Although immigrant negative perceived context of reception (PCOR), perceptions of the opportunities and degree of acceptance in an immigrant-receiving community, has been linked with compromised adolescent well-being, receiving contexts may differ by region and for youth from different ethnic backgrounds. The current study examines how negative PCOR and factors that promote resilience differentially shape mental health among Hispanic and Somali adolescents in Minnesota. Hispanic (n = 163) and Somali (n = 186) first- and second-generation youth aged 12-19 completed a survey on negative PCOR, assets and resources (i.e., ethnic identity, social support, religious participation), and mental well-being (i.e., anxiety and depressive symptoms). Parents and caregivers also completed a survey on PCOR and social support. Adolescent negative PCOR, relative to parent/caregiver negative PCOR, was associated with higher adolescent anxiety and depressive symptoms. Religious participation and social support, reported by both parent/caregiver and adolescent, was associated with lower anxiety and depressive symptoms. Additionally, among Hispanic adolescents, social support buffered the effects of negative PCOR on depressive symptoms. Conversely, strong ethnic identity was associated with higher depressive symptoms for both groups, suggesting acculturative and assimilative pressures play an important role in adolescent mental health. Although social ties can be weakened postmigration, our results indicate that social and religious resources remain beneficial. Given that by the end of the next decade over 50% of the US youth population will identify as part of a racial or ethnic minority group, positive postimmigration adaptation is a critical public health concern.

Serial Cardiac MRI for Quantification of the Dynamics of Anthracycline-Induced Subclinical Myocardial Injury.

BACKGROUND: Anthracyclines are known to be associated with chemotherapy-induced cardiotoxicity. Limited data focus on dynamic myocardial injury during the course of chemotherapy in patients with breast cancer. PURPOSE: To investigate the variation of tissue characterization and myocardial deformation derived by cardiac MRI during anthracycline chemotherapy. STUDY TYPE: Prospective. POPULATION: Fifty-eight female breast cancer patients (mean age: 52.82 ± 2.61 years) were enrolled. FIELD STRENGTH/SEQUENCE: A 3.0-T, cardiac MRI including cine balanced steady-state free precession, a modified Looker-Locker inversion recovery (MOLLI), and a fast spin echo (FSE) T2-weighted sequences were performed. ASSESSMENT: Cardiac MRI was performed baseline and after two, four, and six cycles of chemotherapy. Assessment of global longitudinal strain (GLS), global circumstance strain (GCS), global radial strain (GRS), and strain rate (GLS-s, GCS-s, GRS-s) and T1, T2 and T2* were accomplished by CVI42. The anthracycline dose and risk factors were also collected before each cardiac MRI. STATISTICAL TESTS: Analysis of variance (ANOVA) for repeated measures was used to compare the changes in LVEF cardiac function, strain and T1/T2/T2* parameters over time. Pearson correlation analyses were performed to estimate the potential associations between differences in myocardial characteristics (∆) and the chemotherapy cycle. A P value <0.05 was considered statistically significant. RESULTS: LVEF was not significantly different from pretreatment MRI regarding each cycle of chemotherapy (P = 0.54). Compared with baseline, patients had significantly lower GLS (-15.85% ± 0.83%, -14.50% ± 0.88%, -12.34% ± 1.01% vs. -18.82% ± 0.92%) and GLS-s (-0.71% ± 0.07%, -0.65% ± 0.05%, -0.64% ± 0.04% vs. -0.95 ± 0.06%) and increased T2 values (57.21 ± 4.27 msec, 58.60 ± 3.93 msec, 58.10 ± 3.17 msec vs. 43.88 ± 3.28 msec) at two, four and six cycles of chemotherapy treatment. ∆GLS and ∆GLS-s were significantly associated with the chemotherapy cycle (correlation coefficients for GLS = 0.75, GLS-s = 0.75). DATA CONCLUSION: Cardiac MRI can precisely detect the dynamic changes of anthracycline-induced subclinical myocardial injury that is represented as a gradually decrease in GLS and GLS-s. These parameters may provide new insight for monitoring risk and therapy in patients with breast cancer. EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 1.

Unraveling different influences of the fraction of the tetragonal phase in oxide films on the corrosion resistance of Zr alloys from the phase transition mechanism.

The mechanism of Sn and Nb influence on the fraction of tetragonal ZrO2 in oxide films on Zr alloys and their influence mechanism on corrosion resistance of Zr alloys, despite decades of research, are ambiguous due to the lack of kinetic knowledge of phase evolution of ZrO2 with doping. Using stochastic surface walking and density functional theory calculations, we investigate the influence of Nb and Sn on the stability of tetragonal (t) and monoclinic (m) ZrO2, and t-m phase transition in oxide films. We found that though Nb and Sn result in similar apparent variation trends in the t-phase fraction in oxide films, their influences on t-m phase transition differ significantly, which is the underlying origin of different influences of the t-phase fraction in oxide films on the corrosion resistance of Zr alloys with Sn and Nb alloying. These results clarify an important aspect of the relationship between the microstructure and corrosion resistance of Zr alloys.

Regulation of secretory pathway kinase or kinase-like proteins in human cancers.

Secretory pathway kinase or kinase-like proteins (SPKKPs) are effective in the lumen of the endoplasmic reticulum (ER), Golgi apparatus (GA), and extracellular space. These proteins are involved in secretory signaling pathways and are distinctive from typical protein kinases. Various reports have shown that SPKKPs regulate the tumorigenesis and progression of human cancer via the phosphorylation of various substrates, which is essential in physiological and pathological processes. Emerging evidence has revealed that the expression of SPKKPs in human cancers is regulated by multiple factors. This review summarizes the current understanding of the contribution of SPKKPs in tumorigenesis and the progression of immunity. With the epidemic trend of immunotherapy, targeting SPKKPs may be a novel approach to anticancer therapy. This study briefly discusses the recent advances regarding SPKKPs.

Mycotoxin Occurrence in Feeds and Raw Materials in China: A Five-Year Investigation.

Mycotoxins are ubiquitously present in feeds and raw materials and can exert toxicity on animals and humans. Therefore, mycotoxin occurrence should be monitored. We report here a multi-mycotoxin survey of feed samples in China from 2017 to 2021. Concentrations of aflatoxins, trichothecenes type B, fumonisins, and zearalenone were determined in a total of 9392 samples collected throughout China. Regional differences and year-to-year variation of mycotoxin occurrence were also assessed in new-season corn. Generally, Fusarium mycotoxins were prevalent, while mycotoxin contamination in each feed commodity showed a distinct pattern, e.g., wheat and bran were typically affected by trichothecenes type B, peanut meals were highly susceptible to aflatoxins, and finished feeds exhibited a comparatively high prevalence of all mycotoxins. In new-season corn, trichothecenes type B and fumonisins were most prevalent, with positive rates of 84.04% and 87.16%, respectively. Regions exhibited different patterns of mycotoxin occurrence. The Anhui and Jiangsu provinces of East China exhibited a high prevalence and concentrations of aflatoxins with a positive rate and a positive average of 82.61% and 103.08 µg/kg, respectively. Central China obtained high fumonisins levels of 4707.84 µg/kg. Trichothecenes type B and zearalenone occurred more frequently in temperate regions of Northeast China, and their positive rates reached 94.99% and 55.67%, respectively. In these regions, mycotoxin concentrations in new-season corn exhibited pronounced year-to-year variations and this could be due to the unusual changes of rainfall or temperature during sensitive periods of corn growing. A large fraction of new-season corn samples contained multiple mycotoxins with two to three classes (75.42%), and the most frequently observed co-contaminants were the combination of trichothecenes type B and fumonisins (73.52%). Trichothecenes type B and zearalenone concentrations were highly positively correlated with a coefficient of 0.775. In conclusion, mycotoxins contamination and co-contamination of feeds are common. Mycotoxin contamination in new-season corn exhibited regional patterns and year-to-year variations, with climate and weather conditions as determinant factors.

A Cultural Mismatch Intervention to Increase Science Self-Efficacy Among STEM College Students.

Cultural Mismatch Theory (CMT) suggests mismatch between interdependent home norms and independent school norms can hinder academic success for historically marginalized (HM) students who are more likely to be first-generation college students and underrepresented in science, technology, engineering, and math (STEM). The effectiveness of a CMT intervention to increase science self-efficacy was tested among 213 (Mage = 22.99, SD = 5.74; 8.2% HM) STEM majors from a community college and baccalaureate-granting institution. CMT intervention students reported higher science self-efficacy relative to the control group. The findings support scalable CMT interventions to address STEM workforce disparities.

[GAO Wei-bin's clinical experience in treatment of medulla oblongata paralysis with nape acupuncture].

This paper introduces GAO Wei-bin's academic thought in treatment of medulla oblongata paralysis with acupuncture. Through analyzing the etiologies and locations of medulla oblongata paralysis, in accordance with "selecting the nearby acupoints of the affected area", the acupoints are selected from the nape region, the nape acupuncture therapy and the corresponding new points are developed. Based on the human anatomy of the nape region, the anatomic structures of new points (e.g. Gongxue, Tunyan-1, Tunyan-2, Fayin, Zhiqiang and Tiyan) and their effect mechanism are explained. The treatment principle, "distinguishing the symptoms from the root causes, mutual treatment for both symptoms and root causes", is proposed, and the importance of electric stimulation of nape acupuncture is suggested in treatment of medulla oblongata paralysis.

Mycotoxin contamination in feeds and feed materials in China in year 2020.

A survey of mycotoxin contamination in feed commodities in China was performed and the regional differences of mycotoxin contamination in new season corn was assessed during January 2020-November 2020 in this research. 1,610 samples were analyzed for the major mycotoxins, namely aflatoxins, zearalenone (ZEN), trichothecenes type B, fumonisins (FUM), fusariotoxin T-2 (T-2) and ochratoxin A (OTA) using methods of liquid chromatography-tandem mass spectrometry and enzyme linked immunosorbent assay. Generally, aflatoxins occurred in 16% of all samples, and ZEN, trichothecenes type B and FUM were more prevalent with positive rates of 47, 72, and 63%, respectively. T2 and OTA were rarely detected. In new season corn, samples were also seriously contaminated with ZEN, trichothecenes type B, and FUM at positive rates of 47, 76, and 79%, respectively, and their averages of positives were 112, 735, and 3,811 µg/kg, respectively. The patterns of mycotoxin occurrence showed distinct regional trends in new season corn samples. Samples from Shandong province were highly contaminated with FUM, while special attention should be paid to aflatoxins in Anhui and Jiangsu provinces of East China. The contents of trichothecenes type B and ZEN from northern to southern provinces showed downward trends. In new season corm, co-occurrence of mycotoxins was widespread, and combinations of ZEN, trichothecenes type B, and FUM were frequently observed in this study. Trichothecenes type B and ZEN concentrations showed a positive correlation coefficient of 0.294, suggesting that toxicological interactions of these toxins deserve attention.

Mycotoxin Contamination of Feeds and Raw Materials in China in Year 2021.

In this research, we performed a large-scale survey of mycotoxin contamination in several feed commodities and assessed regional differences in mycotoxin occurrence in maize across China in 2021. Concentrations of aflatoxins, zearalenone (ZEN), fumonisins, and trichothecenes type B were analyzed in 2,643 raw material and compound feed samples collected from eight provinces. Generally, trichothecenes type B, fumonisins, and ZEN were most prevalent and detected in averages of positive concentrations at 1,167, 1,623, and 204 µg/kg, respectively. In the new season maize, samples were also seriously infested with trichothecenes type B, fumonisins, and ZEN, and their averages of positive concentrations were 1,302, 2,518, and 225 µg/kg, respectively. Wheat was commonly contaminated with trichothecenes type B and ZEN, and the highest concentration levels of trichothecenes type B, fumonisins, and ZEN were all detected in the samples from maize by-products. Among the different geographical regions, distinct trends were observed in new season maize. Samples from Shandong province were highly contaminated with trichothecenes type B, fumonisins, and ZEN, while special attention should be paid to aflatoxins and fumonisins in Anhui and Jiangsu provinces in East China. In addition, the present survey showed that compound feeds and raw materials are commonly contaminated by multiple mycotoxins. Trichothecenes type B and ZEN concentrations were correlated significantly in this survey.

Macaque V1 responses to 2nd-order contrast-modulated stimuli and the possible subcortical and cortical contributions.

Natural images comprise contours and boundaries defined by 1st-order luminance-modulated (LM) cues that are readily encoded by V1 neurons, and 2nd-order contrast-modulated (CM) cues that carry local, but not over-the-space, luminance changes. The neurophysiological foundations for CM processing remain unsolved. Here we used two-photon calcium imaging to demonstrate that V1 superficial-layer neurons respond to both LM and CM gratings in awake, fixating, macaques, with overall LM responses stronger than CM responses. Furthermore, adaptation experiments revealed that LM responses were similarly suppressed by LM and CM adaptation, with moderately larger effects by iso-orientation adaptation than by orthogonal adaptation, suggesting that LM and CM orientation responses likely share a strong orientation-non-selective subcortical origin. In contrast, CM responses were substantially more suppressed by iso-orientation than by orthogonal LM and CM adaptation, likely suggesting stronger orientation-specific intracortical influences for CM responses than for LM responses, besides shared orientation-non-selective subcortical influences. These results thus may indicate a subcortical-to-V1 filter-rectify-filter mechanism for CM processing: Local luminance changes in CM stimuli are initially encoded by orientation-non-selective subcortical neurons, and the outputs are half-wave rectified, and then summed by V1 neurons to signal CM orientation, which may be further substantially refined by intracortical influences.

Providing Support Differentially Affects Asian American and Latinx Psychosocial and Physiological Well-Being: A Pilot Study.

Although substantial evidence suggests receiving social support has positive implications for well-being, less is known about how providing support can confer benefits, particularly for Asian American and Latinx individuals who are more likely to come from interdependent cultures that emphasize family obligation. Asian American and Latinx college students (N = 48; M age = 21.44, SD = 2.61; 68.75% female) reported on anxiety before taking part in a modified laboratory task that elicited a physiological stress response as measured by total cortisol output. They were randomly assigned to write (a) a supportive note to a family member, (b) a supportive note to a close friend, or (c) about their day in a control condition after the mild lab stressor and reported on psychosocial well-being (i.e., post-task anxiety and self-esteem). Those who provided support to a family member experienced higher self-esteem compared to those in the control condition. However, there was variation in Asian American and Latinx participants' physiological stress response (i.e., total cortisol output). The findings suggest that providing support to close others, particularly family members, can be differentially meaningful for individuals from diverse backgrounds.

A supramodal and conceptual representation of subsecond time revealed with perceptual learning of temporal interval discrimination.

Subsecond time perception has been frequently attributed to modality-specific timing mechanisms that would predict no cross-modal transfer of temporal perceptual learning. In fact, perceptual learning of temporal interval discrimination (TID) reportedly shows either no cross-modal transfer, or asymmetric transfer from audition to vision, but not vice versa. However, here we demonstrate complete cross-modal transfer of auditory and visual TID learning using a double training paradigm. Specifically, visual TID learning transfers to and optimizes auditory TID when the participants also receive exposure to the auditory temporal interval by practicing a functionally orthogonal near-threshold tone frequency discrimination task at the same trained interval. Auditory TID learning also transfers to and optimizes visual TID with additional practice of an orthogonal near-threshold visual contrast discrimination task at the same trained interval. Practicing these functionally orthogonal tasks per se has no impact on TID thresholds. We interpret the transfer results as indications of a supramodal representation of subsecond time. Moreover, because TID learning shows complete transfer between modalities with vastly different temporal precisions, the sub-second time presentation must be conceptual. Double training may refine this supramodal and conceptual subsecond time representation and connect it to a new sense to improve time perception.

Cortisol awakening response among Latinx and Black students transitioning to college prior to and during the COVID-19 pandemic.

Globally, the COVID-19 (coronavirus disease 2019) pandemic has resulted in abrupt shifts in ecological and social environments, including school contexts, which became predominately virtual. This study (1) examines the role of the COVID-19 pandemic (transitioning to college prior to vs. during the COVID-19 pandemic) on cortisol awakening response (CAR) - a biological marker of chronic psychosocial stress - and university belonging among Latinx and Black first-year college students; and (2) explores whether university belonging serves as a mediator in the relationship between the COVID-19 pandemic and CAR. Latinx and Black students who were in their first semester at a four-year public university in Los Angeles County - one of the United States' hot spots for COVID-19, were recruited for this study. Across two separate cohorts (fall 2019, fall 2020), participants (N = 136) completed an online survey and provided salivary samples to assess for morning cortisol levels. Findings revealed that students who transitioned to college during the COVID-19 pandemic exhibited a flatter CAR and lower levels of belonging than students who transitioned to college prior to the COVID-19 pandemic. Implications for intervention, programs and policies aimed at fostering positive transitions to college during the COVID-19 pandemic and beyond are discussed.