RESUMO
Brain, hypothalamic and pituitary monoamines were measured in 90-day-old male rats after postnatal exposition to electromagnetic microwaves. The treatment decreased brain serotonin, increased brain 5-hydroxyindoleacetic acid and hypothalamo-pituitary catecholamines. The modifications observed in the levels of the monoamines were correlated with the variation of the gonadotrophin secretion described in a previous work. The mechanism by which microwaves could modify brain and hypothalamo-pituitary monoamines is discussed.
Assuntos
Encéfalo/efeitos da radiação , Hipotálamo/efeitos da radiação , Micro-Ondas , Hipófise/efeitos da radiação , Animais , Encéfalo/metabolismo , Dopamina/metabolismo , Ácido Hidroxi-Indolacético/metabolismo , Hipotálamo/metabolismo , Masculino , Neurotransmissores/metabolismo , Norepinefrina/metabolismo , Hipófise/metabolismo , Ratos , Ratos Endogâmicos , Serotonina/metabolismoRESUMO
The influence of daily injections, for 7 days, of 17-hydroxyprogesterone caproate (8 mg/100 g body weight pro die), of estradiol-17 beta 17-undecylate (1.2 mg/100 g body weight pro die) of testosterone enanthate (2 mg/100 g body weight pro die) and of ACTH (4 IU/100 g body weight pro die) to male Wistar rats, weighing 200 g, were investigated. Monamine storage and regulation of enzymes phenylethanolamine N-methyl transferase (PNMT), monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT) were studied in the adrenal glands. Results from testosterone treated rats were especially significant : the hormone administration decreased the stores of dopamine and norepinephrine (epinephrine precursors), stimulated PNMT and decreased metabolism of epinephrine by MAO and COMT. However, the adrenal content of epinephrine remained in the normal range. These findings suggest that uptake of epinephrine is accelerated in peripheral tissues by testosterone.