Eye lens radiation exposure in paediatric interventional treatment of retinoblastoma.

Retinoblastoma represents 3% of cancers in children under fifteen years of age. The standard paediatric treatment for saving the affected eye is supraselective intra-arterial chemotherapy performed in interventional rooms. In order to address the radiation toxicity due to the angiography, the aim of this study was to determine the typical dose value corresponding to the procedure, estimate the paediatric patients' eye lens dose and study the relationship between dose indicators and dose to the lens. An automatic dose management software was installed in two interventional rooms to obtain the distribution of the dose indicators kerma-area product and reference-point air kerma, getting a typical value 16 Gy·cm2 and 130 mGy, respectively (n = 35). The eye lens dose estimates were obtained with photoluminescent dosimeters placed on the patient's eyelids. In the left eye, the entrance surface air kerma was 44.23 ± 2.66 mGy, and 12.72 ± 0.89 mGy in the right eye (n = 10). There was a positive correlation between dose to the lens per procedure and dose indicators, with R2 > 0.65 for both eyes. Based on this information, the threshold for the onset of radiation-induce cataracts (500 mGy) will be exceeded if the treatment is performed for more than 8 sessions.

Eye lens dose levels in interventional rooms using simple phantom simulation, dose management software and Monte Carlo method of uncertainty assessment.

This paper presents a fast method to estimate the annual eye lens dose levels for interventional practitioners applying the Monte Carlo method of uncertainty assessment. The estimation was performed by placing an anthropomorphic phantom in the typical working position, and applying the habitually employed protocol. No radiation protection devices were considered in the simulation. The results were compatible with the measurements performed during interventions by placing dosimeters in the vicinity of the eyes of two paediatric interventional cardiologists working with a fluoroscopic biplane system.

Radiation dose optimisation for conventional imaging in infants and newborns using automatic dose management software: an application of the new 2013/59 EURATOM directive.

Objective: The new 2013/59 EURATOM Directive (ED) demands dosimetric optimisation procedures without undue delay. The aim of this study was to optimise paediatric conventional radiology examinations applying the ED without compromising the clinical diagnosis. METHODS: Automatic dose management software (ADMS) was used to analyse 2678 studies of children from birth to 5 years of age, obtaining local diagnostic reference levels (DRLs) in terms of entrance surface air kerma. Given local DRL for infants and chest examinations exceeded the European Commission (EC) DRL, an optimisation was performed decreasing the kVp and applying the automatic control exposure. To assess the image quality, an analysis of high-contrast resolution (HCSR), signal-to-noise ratio (SNR) and figure of merit (FOM) was performed, as well as a blind test based on the generalised estimating equations method. RESULTS: For newborns and chest examinations, the local DRL exceeded the EC DRL by 113%. After the optimisation, a reduction of 54% was obtained. No significant differences were found in the image quality blind test. A decrease in SNR (-37%) and HCSR (-68%), and an increase in FOM (42%), was observed. CONCLUSION: ADMS allows the fast calculation of local DRLs and the performance of optimisation procedures in babies without delay. However, physical and clinical analyses of image quality remain to be needed to ensure the diagnostic integrity after the optimisation process. Advances in knowledge: ADMS are useful to detect radiation protection problems and to perform optimisation procedures in paediatric conventional imaging without undue delay, as ED requires.

Eye lens dose correlations with personal dose equivalent and patient exposure in paediatric interventional cardiology performed with a fluoroscopic biplane system.

PURPOSE: To analyse the correlations between the eye lens dose estimates performed with dosimeters placed next to the eyes of paediatric interventional cardiologists working with a biplane system, the personal dose equivalent measured on the thorax and the patient dose. METHODS: The eye lens dose was estimated in terms of Hp(0.07) on a monthly basis, placing optically stimulated luminescence dosimeters (OSLDs) on goggles. The Hp(0.07) personal dose equivalent was measured over aprons with whole-body OSLDs. Data on patient dose as recorded by the kerma-area product (PKA) were collected using an automatic dose management system. The 2 paediatric cardiologists working in the facility were involved in the study, and 222 interventions in a 1-year period were evaluated. The ceiling-suspended screen was often disregarded during interventions. RESULTS: The annual eye lens doses estimated on goggles were 4.13±0.93 and 4.98±1.28mSv. Over the aprons, the doses obtained were 10.83±0.99 and 11.97±1.44mSv. The correlation between the goggles and the apron dose was R2=0.89, with a ratio of 0.38. The correlation with the patient dose was R2=0.40, with a ratio of 1.79µSvGy-1cm-2. The dose per procedure obtained over the aprons was 102±16µSv, and on goggles 40±9µSv. The eye lens dose normalized to PKA was 2.21±0.58µSvGy-1cm-2. CONCLUSIONS: Measurements of personal dose equivalent over the paediatric cardiologist's apron are useful to estimate eye lens dose levels if no radiation protection devices are typically used.

Spanish experience in education and training in radiation protection in medicine.

In most of its publications, the International Commission on Radiological Protection has highlighted the importance of education and training in radiation protection (RP) for medical exposures. Spain, like other Member States of the European Union, has implemented the Directive and the Guidelines in the medical area. The purpose of this paper is to present the Spanish experience in RP education and training in medicine, the different objectives established according to professional levels, existing regulations and feedback obtained from various RP actions.

Physical image quality comparison of four types of digital detector for chest radiology.

Image quality for similar exposure conditions has been compared for two computed radiography (CR) systems (needle-based and conventional storage phosphor) and two flat-panel (DR) systems from different manufacturers mainly devoted to chest radiology. Image quality was assessed with a contrast-detail object and acrylic material to simulate clinical conditions. Specific image evaluation software was used to measure the contrast and obtain an image quality figure. Phantom and detector incident air kerma were measured for all images. Image quality differences were significant, and in the range of 100-300 microGy (phantom incident air kerma) the needle-based CR system and one of the DR systems show similar image quality and they are quite superior when compared with the conventional CR system.

Influence of patient thickness and operation modes on occupational and patient radiation doses in interventional cardiology.

Patient and staff dose values in an interventional cardiology laboratory for different operational modes and several patient thicknesses (from 16 to 28 cm, simulated using polymethylmethacrylate) are presented. When increasing patient thicknesses and depending on fluoroscopy and cine modes, occupational doses can increase >30 times the baseline level. Scatter dose rates at the cardiologist's position with no radiation protective tools ranged from 1 to 14 mSv h(-1) for fluoroscopy, and from 10 to 47 mSv h(-1) during cine acquisition. Patient entrance surface air kerma rates increased by nearly 3 and staff dose rates by up to 2.6 when fluoroscopy was moved from the low to the high mode, for a typical 20 cm thickness. The respective increase factors were 6 and 4.2 when patient thickness rose from 16 to 28 cm, and by 10 and 8.3, when comparing cine acquisition with the low fluoroscopy mode. The knowledge of typical dose rates for each X-ray system in use in catheterisation laboratories is essential in order to optimise protection of patients and staff.

Quantification of motion unsharpness in digital fluoroscopy.

The objectives of this work were first to develop a convenient method to quantify persistence in digital fluoroscopy systems, then to quantify the effect of variable temporal averaging on the detection of moving low-contrast test details within digital fluoroscopic and pulsed fluoroscopic images. The results were analysed to clarify the relationship between the optimum persistence required to see the lowest contrast for circular test details for a range of diameters and their speed of movement. The optimum persistence values obtained are compared with the limited data available on speeds of movement of patient organs during fluoroscopy. It is tentatively concluded that for imaging the abdomen, the optimum imaging system persistence time constant is approximately 0.15 s. For the much greater speeds associated with cardiac motion, no additional frame averaging is necessary, i.e. just the persistence provided by the observer's visual system appears to be optimal for small objects.

Patient dosimetry and image quality in digital radiology from online audit of the X-ray system.

The present work describes an online patient dosimetry and an image quality system in digital radiology. For the patient dosimetry audit, current mean values of entrance surface dose (ESD) were compared with local and national reference values (RVs) for the specific examination type evaluated. Mean values exceeding the RV trigger an alarm signal and then an evaluation of the technical parameters, operational practice and image quality was begun, using data available in the DICOM header to derive any abnormal settings or performance to obtain the image. The X-ray tube output for different kVp values is measured periodically, to allow for the automatic calculation of ESD. The system allows also for image audit, linking the dose imparted, the image quality and the alarm condition, if produced. Results and the benefits derived from this online quality control are discussed here.

Evaluation of risk of deterministic effects in fluoroscopically guided procedures.

A methodology for the evaluation of skin dose distribution and possible skin injuries on patients undergoing interventional procedures has been developed as part of the European DIMOND programme. Relevant dosimetric data from the procedures are recorded and other specific measurements for skin dose evaluation (slow films for therapy, radiochromic films, thermoluminescence dosemeters and optically stimulated luminescence dosemeters) have been carried out. For non-cardiac and for some cardiac procedures, dose-area product values of 200 and 300 Gy cm2 were proposed, respectively, as a trigger level for further detailed skin dose investigation and possible clinical follow-up. Results from a survey of 191 selected complex procedures are reported. Out of all the patients included in the trial, 16% received skin doses > or =1.5 Gy. No skin injuries were found in any of the patients followed.

Suitability of resin-coated photographic paper for skin dose measurement during fluoroscopically-guided X-ray procedures.

The need for mapping skin doses during fluoroscopically-guided X-ray procedures has been described by a number of institutions and experts. Different large photographic or X-ray films placed on the patient's skin have been found to be useful for recording doses up to 1.0-2.0 Gy - depending on the film - and up to 15 Gy using radiochromic films. Though the upper limit of the film sensitivity is seldom exceeded during interventional procedures, the main disadvantage of the X-ray films is still the excessive sensitivity for long, high dose procedures. Radiochromic films show poor definition for doses below 0.5 Gy and are expensive. The goal of the present paper is to analyse the possibilities of using common resin-coated photographic paper for this purpose. Sensitometric curves obtained with different paper types processed in conventional X-ray film automatic processors demonstrate that some of them can be used with better results than X-ray films at a very low cost. Doses from about 10 mGy to near 3.0 Gy can be measured with good accuracy using a variety of glossy photographic papers.

Optimization of variable temporal averaging in digital fluoroscopy.

In modern X-ray fluoroscopy systems, the amount of temporal averaging (i.e. persistence) applied to the image is often user selectable. The objective of this work is to quantify the effect of variable temporal averaging on the detection of low contrast test objects moving at a range of known speeds within the digital fluoroscopic image. An image intensifier system with a short-persistence television camera was used to record image sequences of a moving threshold contrast-detail diameter test object onto broadcast-standard U-matic videotape. The image sequences were replayed through an image processing system allowing different amounts of temporal averaging to be applied. The test images were scored by an experienced observer. The temporal averaging time constants produced by the added image processing were measured using a method based on noise correlation. Results are presented showing the trends of threshold contrast with test detail diameter and movement speed. The optimum value of temporal averaging time constant is presented as a function of detail diameter for a range of speeds. By comparison with the limited information available in the literature on organ movement, it is tentatively concluded that for the organ movement speeds expected in the abdomen, the optimum imaging system persistence time constant should be approximately 0.15 s. For the much greater speeds associated with cardiac motion no additional frame averaging, i.e. just the persistence provided by the observer's visual system, appears to be optimal.

Short communication: Practical aspects for the evaluation of skin doses in interventional cardiology using a new slow film.

Mapping skin doses in complex fluoroscopy interventions is useful to determine the probability of a possible injury, to detect areas of overlapping irradiation fields and to obtain a permanent register of the most exposed patient skin areas. To fulfil this task, large films with slow X-ray response can be used. Recently, Kodak has introduced a new radiotherapy verification film, named EDR2 (Extended Dose Range). The aim of this paper is to analyse the possibilities of using this new film for estimating skin dose distributions in interventions with potentially higher doses, such as complex percutaneous transluminal coronary angioplasty (PTCA), intravascular brachytherapy procedures (IVB) or cardiac ablations. The EDR2 film by Kodak is an improved option to be used in interventional cardiology to obtain maps of patient skin doses and to estimate maximum skin doses up to 1400 mGy. Film kVp dependence is negligible and the processor conditions can be standardized to obtain skin dose estimations. The linear range for accurate dose measurements is from 50 mGy to 500 mGy.

Skin dose and dose-area product values for interventional cardiology procedures.

Coronary angiography and percutaneous transluminal coronary angioplasty procedures performed in four different facilities were monitored in the present study by measuring maximum skin dose, dose-area product and other operational parameters. Radiographic slow film, thermoluminescent dosemeters and transmission ion chambers were used to measure dose related quantities. Values of 107-711 mGy for maximum skin dose and 27.3-370.6 Gy cm2 for dose-area product were found, together with cumulative skin dose estimates of 110-3706 mGy. A discussion of the relationship of measured dose-area product and skin dose values is made using a field concentration factor defined as a way to interpret the findings. No general correlation was observed between dose-area product and maximum skin dose. Cumulative skin dose estimates throughout a procedure should be discarded as a realistic method for assessing deterministic risk in cardiology procedures. Slow film in addition to thermoluminescent dosemeters for measurement of maximum skin dose is a good alternative, especially for complex interventional procedures. For repeated procedures, combining film and dose-area product monitoring favours optimization of radiation protection for the patient.

Radiation exposure to medical staff in interventional and cardiac radiology.

The aim of this work has been to determine typical occupational dose levels in interventional radiology and cardiology installations and to relate doses to patient and occupational dosimetry through the dose-area product. An experimental correlation between environmental dosimetric records and dose-area products in the centres studied was established. The study covered a sample of 83 procedures performed by 10 specialists in six laboratories. The radiologists and cardiologists monitored wore nine thermoluminescent chips next to eyes, forehead, neck, hands, left shoulder, left forearm and left arm during each single procedure. In addition, direct reading electronic devices for environmental dosimetry were placed in the C-arm of the X-ray system, to estimate roughly the occupational radiation risk level. Typical shoulder doses derived from electronic dosimetry range between 300 and 500 muSv per procedure, assuming no lead protective screens were used. Using these values and patient dose-area data from two laboratories, averaged ratios of 84 and 120 muSv per 1000 cGy cm2 are obtained for cardiology procedures. Finally, occupational dose reductions of approximately 20% when using highly filtered X-ray beams with automatic tube potential (kV) reduction (available in some facilities), and by a factor of about three when using ceiling mounted screens, have been found.

Design of a PC controlled test device for the study of patient motion in X-ray radiology: first applications and results.

Simulation and study of patient motion should be undertaken for different imaging techniques since all new radiological techniques or equipment must pass through evaluation processes to verify their functional capability and assess their performance compared with other equipment. A device to study the effects of motion on X-ray image quality was designed and built. The main goal of the PC controlled device developed by our group is to allow the adaptation of different phantoms and test objects. Preliminary experiments for the evaluation of different thorax screen-film systems were carried out by simulating respiratory motion. It is concluded that moving objects should be included for the comparison of screen-film systems since predictions based only on findings in stationary test conditions could lead to false conclusions.

Patient dosimetry in interventional radiology using slow films.

A method for the evaluation of patient doses in interventional radiology procedures is presented and discussed. The method requires the analysis of slow non-screen films such as those used in radiotherapy. Dose area product and patient skin dose can be estimated with fair accuracy depending on the interventional procedure type. The agreement between the slow film method and diamentor measurement is better than 5% after the application of appropriate corrections. The cost is reasonable (pounds 5 per film) making it a worthwhile option in patient dosimetry, especially when the X-ray equipment does not include any fixed dose-area measuring device. Additional valuable information which may be applied to optimization of procedures (e.g. irradiated areas, number and types of projections check of appropriate use of beam limiting devices) is achieved by examining the different irradiation fields on the film.

Patient doses in hysterosalpingography.

The results of a survey of doses imparted on 41 patients undergoing hysterosalpingography is presented. Dosimetric evaluations were carried out by measuring both the dose-area product using a transmission ionization type chamber, and the entrance surface dose using thermoluminiscent dosimeters. As a result, a local reference dose value was obtained for this examination. Correlations between the dose-area product and the entrance surface dose data were analysed and compared in order to find the most appropriate dosimetric procedure. The median dose-area product obtained was 713 cGy cm2 (range 247 cGy cm2-1623 cGy cm2). Ovarian doses were also calculated, and a median value of 4.6 mGy was obtained for the whole examination. Effective doses were estimated with a median value of 3.1 mSv, and a range of 1.0 mSv-8.1 mSv.

Short communication: use of the European image quality criteria for screen-film comparison--application for asymmetric systems.

The aim of this study is the comparison of two different techniques of image evaluation: by phantom simulation and by patient anatomical criteria using those proposed in a European Union working document. Both methods of evaluation were applied to asymmetric and conventional screen-film systems. The European image quality criteria as a tool for comparing the use of image systems is a reasonably valid and objective method. However, a complete practical description of a system using complementary phantom images and test object is a convenient means of obtaining a comprehensive description of the system. Results show that sharpness of mobile organs and the visualization of the retrocardiac and retromammal lung, in posteroanterior projection, and vertex in lateral projection is improved with the InSight system. The phantom images suggest, however, an important loss of resolution and contrast.

Image quality and dose in lumbar spine examinations: results of a 5 year quality control programme following the European quality criteria trial.

The large dose values found for lumbar spine examinations in a centre participating in the European quality criteria trial have been investigated within a 5 year quality control programme. Actions focused mainly on optimizing the focus-to-film distance, tube potential (kV), film optical density and X-ray beam filtration. These actions lead to overall dose reductions of up to 75% in lumbo-sacral joint examinations and prove the need for a regular survey of patient skin doses.