[Certain aspects of neoadjuvant therapy of locally advanced breast cancer]. / Nekotorye aspekty neoad"iuvantnoi terapii mestnorasprostranenogo raka molochnoi zhelezy.

The paper presents the results of a complex investigation of patients with locally-advanced breast cancer who received neoadjuvant chemotherapy or chemoradiation at initial stage. The clinical and pathomorphological effects, nature of neoadjuvant therapy and number of courses were followed up for 5- and 10-year periods. A direct correlation was found between number of courses for chemotherapy-sensitive patients, on the one hand, and greater effect, more intensive medicinal pathomorphism and longer recurrence-free survival, particularly, at later stages, on the other.

[Some prognostic factors in the combined therapy of locally advanced breast cancer]. / Hekotorye prognosticheskie faktory v kompleksnom lecheniie mestnorasprostranennogo raka molochnoi zhelezy.

A relationship between the dynamics of growth and pathological response of tumor cells and the number of neoadjuvant chemotherapy courses was established. As a result, there was no correlation between increase in overall and disease-free survival, on the one hand, and stage, on the other. An interval between neoadjuvant chemotherapy and surgery longer than 4 weeks had a negative effect on overall tumor response and duration of disease-free period.

[Role of induction chemo- and radiotherapy in the treatment of locally advance breast cancer]. / Znachenie induktsionnoi luchevoi i khimioterapii v lechenii mestnorasprostranennogo raka molochnoi zhelezy.

336 patients with locally-advanced breast cancer underwent neoadjuvant chemotherapy or chemoradiotherapy. Increase in T- and N-indices (change of stage after neoadjuvant chemotherapy) proved an important prognostic factor. Survival rates correlated with clinical effect and dropped as it diminished. This tendency was clear in both groups. There was no relationship between stage and overall and disease-free survival rates at early stages but later they declined as T- and N-indices decreased.

[Correlation of clinical effect, pathological response of tumor cells and the end results of combined treatment of locally advanced breast cancer]. / Korrelatsiia klinicheskogo éffekta, patomorfoza opukholevykh kletok i otdalënnykh rezul'tatov kompleksnogo lecheniia bol'nykh s mestnorasprostranennym rakom molochnoi zhelezy.

A correlation was established between the end-results of neoadjuvant chemotherapy for locally-advanced breast cancer and pathological response of tumor cells. Also, the end-results correlated with CR or PR and pathological response. Only a small proportion of patients with tumor progression were registered as stage III or IV of pathological response (0.6 and 0.8%, respectively).