RESUMO
The studyHarris M, Holland A, Lewer D, et al. Barriers to management of opioid withdrawal in hospitals in England: a document analysis of hospital policies on the management of substance dependence. BMC Med 2022;20:151.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/many-hospital-policies-create-barriers-to-good-management-of-opioid-withdrawal/.
Assuntos
Analgésicos Opioides , Síndrome de Abstinência a Substâncias , Humanos , Analgésicos Opioides/efeitos adversos , Síndrome de Abstinência a Substâncias/tratamento farmacológico , Políticas , Hospitais , InglaterraRESUMO
The studyHong JSW, Atkinson LZ, Al-Juffali N, et al. Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: systematic review, meta-analysis, and rationale. Mol Psychiatry 2022;27:1339-49.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/review-finds-little-evidence-support-gabapentinoid-use-bipolar-disorder-or-insomnia/.
Assuntos
Transtorno Bipolar , Distúrbios do Início e da Manutenção do Sono , Humanos , Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico , Transtorno Bipolar/tratamento farmacológico , Gabapentina/uso terapêutico , Pregabalina/uso terapêuticoRESUMO
The studySmith CM, Lall R, Fothergill RT, Spaight R, Perkins GD. The effect of the GoodSAM volunteer first-responder app on survival to hospital discharge following out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care 2022;11:20-31.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/more-people-survived-cardiac-arrest-first-aiders-goodsam-alert/.
Assuntos
Reanimação Cardiopulmonar , Serviços Médicos de Emergência , Socorristas , Aplicativos Móveis , Parada Cardíaca Extra-Hospitalar , Humanos , Parada Cardíaca Extra-Hospitalar/terapiaRESUMO
The studyVennik J, Hughes S, Smith KA, et al. Patient and practitioner priorities and concerns about primary healthcare interactions for osteoarthritis: a meta-ethnography. Patient Educ Couns 2022;105:1865-77.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/discussions-about-osteoarthritis-in-primary-care/.
Assuntos
Osteoartrite , Humanos , Osteoartrite/terapia , Atenção Primária à SaúdeRESUMO
The studyEvans JT, Mouchti S, Blom AW, et al. Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry: a UK cohort study. PLoS Med 2021;18:7.
Assuntos
Artroplastia do Joelho , Humanos , Estudos de Coortes , Reoperação , Sistema de Registros , Obesidade/cirurgiaRESUMO
The studyBuckman JEJ, Saunders R, Stott J, et al. Socioeconomic indicators of treatment prognosis for adults with depression: a systematic review and individual patient data meta-analysis. JAMA Psychiatry 2022;79:5.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/unemployment-insecure-housing-linked-less-successful-depression-treatment/.
Assuntos
Habitação , Desemprego , Adulto , Depressão/terapia , Humanos , Fatores SocioeconômicosRESUMO
The studyHopewell S, Keene DJ, Marian IR, et al. Progressive exercise compared with best practice advice, with or without corticosteroid injection, for the treatment of patients with rotator cuff disorders (GRASP): a multicentre, pragmatic, 2 × 2 factorial, randomised controlled trial. Lancet 2021;398:416-28.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/one-off-physiotherapy-session-effective-for-shoulder-pain/.
Assuntos
Terapia por Exercício , Dor de Ombro , Exercício Físico , Humanos , Modalidades de Fisioterapia , Manguito Rotador , Dor de Ombro/terapia , Resultado do TratamentoRESUMO
The studyAntonelli M, Penfold RS, Merino J, et al. Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study. Lancet Infect Dis 2022;22:1.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/older-people-at-risk-from-covid-even-after-vaccine/.
Assuntos
COVID-19 , Idoso , COVID-19/epidemiologia , COVID-19/prevenção & controle , Estudos de Casos e Controles , Idoso Fragilizado , Humanos , Estudos Prospectivos , SARS-CoV-2 , VacinaçãoRESUMO
Immune function and sensitivity to pain are closely related, but the association between early life inflammation and sensory nervous system development is poorly understood-especially in humans. Here, in term-born infants, we measure brain activity and reflex withdrawal activity (using EEG and EMG) and behavioural and physiological activity (using the PIPP-R score) to assess the impact of suspected early-onset neonatal infection on tactile- and noxious-evoked responses. We present evidence that neonatal inflammation (assessed by measuring C-reactive protein levels) is associated with increased spinal cord excitability and evoked brain activity following both tactile and noxious stimulation. There are early indications that this hyperalgesia could be maintained post-inflammation, supporting pre-clinical reports of early-life immune dysfunction influencing pain sensitivity in adults.
Assuntos
Nociceptividade , Medula Espinal , Humanos , Hiperalgesia , Recém-Nascido , Inflamação , Dor , Medula Espinal/fisiologiaRESUMO
The studyThe Blood Pressure Lowering Treatment Trialists' Collaboration. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis. Lancet 2021;398:1053-64.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/people-of-all-ages-benefit-from-drugs-to-lower-blood-pressure/.
Assuntos
Doenças Cardiovasculares , Hipertensão , Anti-Hipertensivos/farmacologia , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea , Doenças Cardiovasculares/tratamento farmacológico , Doenças Cardiovasculares/prevenção & controle , Humanos , Hipertensão/tratamento farmacológico , Metanálise como Assunto , Sinais VitaisRESUMO
The studyMcElroy E, Ashton M, Bagnall AM, et al. The individual, place, and wellbeing-a network analysis. BMC Public Health 2021;21:1621.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/open-spaces-and-community-cohesion-improve-wellbeing/.
RESUMO
The studyHutchinson P, Edlmann E, Bulters D, et al. Trial of dexamethasone for chronic subdural haematoma. N Engl J Med 2020;383:2616-27.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/dexamethasone-should-not-be-used-chronic-subdural-haematoma/.
Assuntos
Hematoma Subdural Crônico , Dexametasona/efeitos adversos , Hematoma Subdural Crônico/tratamento farmacológico , HumanosRESUMO
The studyDuffy L, Clarke CS, Lewis G, et al. Antidepressant medication to prevent depression relapse in primary care: the ANTLER RCT. Health Technol Assess 2021;25:69.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/almost-half-people-long-term-antidepressants-stop-without-relapse/.
Assuntos
Antidepressivos , Registros , Antidepressivos/uso terapêutico , Humanos , RecidivaRESUMO
The studyBion J, Aldridge C, Beet C, et al. Increasing specialist intensity at weekends to improve outcomes for patients undergoing emergency hospital admission: the HiSLAC two-phase mixed-methods study. HSDR 2021;9:13.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/hospital-emergency-care-is-as-good-at-the-weekend-as-on-weekdays/.
Assuntos
Serviços Médicos de Emergência , Hospitais , Serviço Hospitalar de Emergência , Mortalidade Hospitalar , Hospitalização , Humanos , Estudos RetrospectivosRESUMO
The studyHollis C, Hall CL, Jones R, et al. Therapist supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial. Lancet Psychiatry 2021;8:P871-82.
Assuntos
Intervenção Baseada em Internet , Tiques , Adolescente , Criança , Inglaterra , Humanos , Método Simples-Cego , Tiques/terapiaRESUMO
The studyHerbert A, Rafiq M, Pham TM, et al. Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK: a cohort study. PLoS Med 2021:18;e1003708.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/combining-risks-cancer-and-ibd-allows-more-fast-track-referrals/.
Assuntos
Doenças Inflamatórias Intestinais , Encaminhamento e Consulta , Estudos de Coortes , Humanos , Doenças Inflamatórias Intestinais/diagnóstico , Doenças Inflamatórias Intestinais/terapiaRESUMO
The studyDrake TM, Riad AM, Fairfield CJ, et al. Characterisation of in-hospital complications associated with covid-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. Lancet 2021;398:10296.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/one-in-two-people-hospitalised-with-covid-19-develop-complications-may-need-support/.
Assuntos
COVID-19 , COVID-19/complicações , Estudos de Coortes , Hospitalização , Hospitais , Humanos , Estudos ProspectivosRESUMO
The studySharpe D, Rajabi M, Harden A, et al. Supporting disengaged children and young people living with diabetes to self-care: a qualitative study in a socially disadvantaged and ethnically diverse urban area. BMJ Open 2021;11:e046989.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/why-dont-young-people-engage-with-diabetes-services/.
Assuntos
Diabetes Mellitus , Adolescente , Criança , Diabetes Mellitus/terapia , Humanos , Pesquisa Qualitativa , AutocuidadoRESUMO
The studyCrossingham I, Turner S, Ramakrishnan S, et al. Combination fixed-dose ß agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review. BMJ Evid Based Med 2021; doi:10.1136/bmjebm-2021-111764To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/combination-inhaler-is-effective-in-mild-asthma/.
Assuntos
Asma , Nebulizadores e Vaporizadores , Adulto , Asma/tratamento farmacológico , Criança , HumanosRESUMO
The studyWilson JA, Stocken DD, Watson GC, et al. Lansoprazole for persistent throat symptoms in secondary care: the TOPPITS RCT. Health Technol Assess 2021;25:1-118.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/throat-symptoms-should-not-be-treated-with-ppis/.