RESUMO
The paper reviews the literature on studies of the structural and functional properties of great arteries in patients with cardiovascular diseases. It analyses the pathophysiological components of the formation of central blood pressure (BP) and describes current registration procedures. The negative aspects of the impact of elevated central BP on target organs are considered. The prognostic and clinical values of the indicators of central arterial stiffness are demonstrated.
Assuntos
Aorta/fisiopatologia , Pressão Arterial/fisiologia , Doenças Cardiovasculares , Rigidez Vascular/fisiologia , Aorta/patologia , Determinação da Pressão Arterial , Doenças Cardiovasculares/patologia , Doenças Cardiovasculares/fisiopatologia , Elasticidade , Humanos , Valor Preditivo dos Testes , PrognósticoRESUMO
In an open prospective 16-week study we carried out assessment of clinical efficacy, vaso- and cardioprotective properties of nonselective alpha and beta-adrenoblocker carvedilol used as monotherapy and in combination with nifedipine or as combination of these drugs with metformin and simvastatin. We have shown that the use of carvedilol both as monotherapy and in combination with nifedipine normalizes arterial pressure irrespective of the number of risk factors. We also revealed pronounced cardio- and vasoprotective action without negative effect on carbohydrate and lipid metabolism.
