Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease.

BACKGROUND: Cardiovascular disease is the leading cause of death in the Western world, and a major cause of this disease is atherosclerosis. Research has demonstrated that pregnancy-associated plasma protein A (PAPP-A) plays a role in cardiovascular disease, as evidenced by the association between PAPP-A and severity of heart damage. AIM: The aim of this work was to investigate the correlation between PAPP-A concentrations in coronary and peripheral blood and certain clinicopathological factors and antioxidant enzyme activities in patients diagnosed with coronary artery disease. METHODS: For 65 patients, arterial blood was obtained by puncturing the femoral or radial artery, and coronary blood was obtained via percutaneous coronary intervention. PAPP-A, catalase (CAT), superoxide dismutase-1 (SOD-1), and superoxide dismutase-2 (SOD-2) levels were measured using spectrometric methods. RESULTS: Coronary PAPP-A levels were slightly higher than peripheral PAPP-A levels (81.25 ± 2.34 and 62 ± 3 ng/mL, respectively, P < 0.0001); these levels were correlated with each other (r = 0.6629, P < 0.001) but not with clinicopathological factors (P > 0.05). Coronary PAPP-A levels were significantly elevated among patients at risk for cardiovascular disease (P < 0.05). Antioxidant enzyme activities were significantly higher in coronary samples than in peripheral samples from subjects with ischemic cardiopathy secondary to atherosclerosis (P < 0.001). Neither coronary nor peripheral PAPP-A levels were correlated with antioxidant enzyme activities in patients with cardiopathy secondary to atherosclerosis (P > 0.05). CONCLUSIONS: PAPP-A levels could be used as biomarkers to identify patients at risk of coronary artery disease.

[Usefulness of magnetic resonance images in percutaneous angioplasty for aortic coarctation]. / Utilidad de imágenes por resonancia magnética en la angioplastía percutánea de coartación aórtica.

From October 1985 to February 1992, we performed 80 percutaneous transluminal angioplasty procedures (PTA) in 76 patients with Coarctation of the Aorta (CoAo). Twenty eight patients (aged 2.6 to 62 years; mean, 11.4) underwent Magnetic Resonance Imaging (MRI) during the follow-up period, 2 to 60 months (m = 16) after dilation. Three of these patients were also studied before PTA. We found mild residual coarctation in 11, minimal irregularities in the aorta in five and excellent results in twelve cases. No aneurysms were found. In those patients that underwent MRI before the angioplasty was possible to choose the balloon, thus reducing the time during dilatation. In conclusion we believe that MRI is an excellent and well suited alternative for the serial studies in patients with CoAo, before PTA and in the follow-up.