RESUMO
Preeclampsia, a common complication of pregnancy, is associated with alteration in the concentration of leptin in maternal blood. The action of leptin is antagonistic to that of ghrelin. Here, we compared the levels of leptin and ghrelin in maternal serum and in arterial and venous cord blood between healthy pregnant women and those suffering from mild and severe preeclampsia. The levels of leptin in maternal and newborn's blood were elevated in both mild and severe preeclamptic patients (p < 0.05). Moreover, serum ghrelin levels were negatively correlated with blood pressure and leptin/ghrelin ratio was decreased in preeclampsia (p < 0.05). We concluded that increased production of ghrelin may represent a compensatory hypotensive mechanism in preeclamptic women.
Assuntos
Adaptação Fisiológica/fisiologia , Grelina/sangue , Leptina/sangue , Pré-Eclâmpsia/metabolismo , Pré-Eclâmpsia/fisiopatologia , Adulto , Artérias , Pressão Sanguínea/fisiologia , Feminino , Sangue Fetal , Humanos , Recém-Nascido , Gravidez , VeiasRESUMO
Preeclampsia, a common complication of pregnancy, is associated with alterationin the concentration of leptin in maternal blood. The action of leptin is antagonisticto that of ghrelin. Here, we compared the levels of leptin and ghrelin in maternalserum and in arterial and venous cord blood between healthy pregnant women andthose suffering from mild and severe preeclampsia. The levels of leptin in maternaland newborns blood were elevated in both mild and severe preeclamptic patients(p<0.05). Moreover, serum ghrelin levels were negatively correlated with blood pressureand leptin/ghrelin ratio was decreased in preeclampsia (p<0.05). We concludedthat increased production of ghrelin may represent a compensatory hypotensivemechanism in preeclamptic women (AU)
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Assuntos
Humanos , Recém-Nascido , Adulto , Feminino , Gravidez , Adaptação Fisiológica/fisiologia , Grelina/sangue , Leptina/sangue , Pré-Eclâmpsia/metabolismo , Artérias/metabolismo , Artérias/fisiologia , Pressão Sanguínea/fisiologia , Pré-Eclâmpsia/fisiopatologia , Sangue Fetal/metabolismo , Sangue Fetal/fisiologia , Veias/metabolismo , Veias/fisiologia , Hipertensão/complicações , Complicações na Gravidez/metabolismoRESUMO
Ghrelin (G-HH) synthesized in several tissues including salivary and stomach glands stimulates appetite in humans by modulating neuropeptide Y neurons in the hypothalamic arcuate nucleus. Loss of appetite is one of the most important symptoms of stomach cancer. We conducted a study using immunohistochemistry to determine whether salivary glands and stomach cancer tissues produce ghrelin. We determined that negative ghrelin immunohistochemistry discriminates tumors from normal tissues and may therefore further our understanding of the clinically important problem of reduced food intake and anorexia in cancer patients. Radioimmunoassay analyses confirmed that cancer cells do not produce a G-HH peptide, whereas normal cells yield this peptide.
