Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Neurosci Lett ; 609: 18-22, 2015 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-26455962

RESUMO

Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.


Assuntos
Anestésicos Intravenosos/farmacologia , Cerebelo/efeitos dos fármacos , Depressão Sináptica de Longo Prazo/efeitos dos fármacos , Propofol/farmacologia , Animais , Cerebelo/fisiologia , Técnicas In Vitro , Células de Purkinje/efeitos dos fármacos , Células de Purkinje/fisiologia , Ratos Wistar , Receptores de Glutamato Metabotrópico/metabolismo
2.
Korean J Ophthalmol ; 22(2): 73-6, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18612222

RESUMO

PURPOSE: We report a simple and effective method of identifying the medial cut end of lower canalicular laceration cases. METHODS: Twenty-seven eyes with lower canalicular lacerations as a result of trauma were involved in the study. Surgery was performed within 48 hours after injury for canalicular reconstruction. Upper canalicular probing was utilized to identify the medial cut end of deep canalicular lacerations when difficulties were encountered. Total time from the initiation of the probing procedure to the identification of the medial cut end of the lower canaliculus was measured. RESULTS: A total of 27 eyes with lower canalicular lacerations were reconstructed. In 20 eyes, the medial lacerated end was located by upper canalicular probing. The mean time from initiation of the probing procedure to identification of the medial cut end of the lacerated canaliculus was 2 minutes. CONCLUSIONS: We conclude that upper canalicular probing in patients with lower canalicular lacerations significantly reduces the time from the initiation of the operation to the identification of the medial cut end of the lower canaliculus.


Assuntos
Traumatismos Oculares/diagnóstico por imagem , Pálpebras/lesões , Lacerações/diagnóstico por imagem , Aparelho Lacrimal/lesões , Adolescente , Adulto , Idoso , Criança , Técnicas de Diagnóstico Oftalmológico , Traumatismos Oculares/cirurgia , Feminino , Humanos , Intubação/métodos , Lacerações/cirurgia , Aparelho Lacrimal/diagnóstico por imagem , Aparelho Lacrimal/cirurgia , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Oftalmológicos , Radiografia , Fatores de Tempo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA