An Unsymmetric Ligand Framework for Noncoupled Homo- and Heterobimetallic Complexes.

We introduce a new unsymmetric ligand, PDIpCy (PDI = pyridyldiimine; Cy = cyclam), that offers two distinct, noncoupled coordination sites. A series of homo- and heterobimetallic complexes, [Zn2(PDIpCy)(THF)(OTf)4] (1; THF = tetrahydrofuran and OTf = triflate), [Ni2(PDIpCy)(THF)(OTf)2](OTf)2 (2), and [NiZn(PDIpCy)(THF)(OTf)4] (3), are described. The one-electron-reduced compounds, [Zn2(PDIpCy)(OTF)3] (4), [Ni2(PDIpCy)(OTf)](OTf)2 (5), and [NiZn(PDIpCy)(OTf)3] (6), were isolated, and their electronic structures were characterized. The reduced compounds are charge-separated species, with electron storage at either the PDI ligand (4) or at the PDI-bound metal ion (5 and 6).

A double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [13C6]-labeled basimglurant in humans.

1. The emerging technique of employing intravenous microdose administration of an isotope tracer concomitantly with an [14C]-labeled oral dose was used to characterize the disposition and absolute bioavailability of a novel metabotropic glutamate 5 (mGlu5) receptor antagonist under clinical development for major depressive disorder (MDD). 2. Six healthy volunteers received a single 1 mg [12C/14C]-basimglurant (2.22 MBq) oral dose and a concomitant i.v. tracer dose of 100 µg of [13C6]-basimglurant. Concentrations of [12C]-basimglurant and the stable isotope [13C6]-basimglurant were determined in plasma by a specific LC/MS-MS method. Total [14C] radioactivity was determined in whole blood, plasma, urine and feces by liquid scintillation counting. Metabolic profiling was conducted in plasma, urine, blood cell pellet and feces samples. 3. The mean absolute bioavailability after oral administration (F) of basimglurant was ∼67% (range 45.7-77.7%). The major route of [14C]-radioactivity excretion, primarily in form of metabolites, was in urine (mean recovery 73.4%), with the remainder excreted in feces (mean recovery 26.5%). The median tmax for [12C]-basimglurant after the oral administration was 0.71 h (range 0.58-1.00) and the mean terminal half-life was 77.2 ± 38.5 h. Terminal half-life for the [14C]-basimglurant was 178 h indicating presence of metabolites with a longer terminal half-life. Five metabolites were identified with M1-Glucuronide as major and the others in trace amounts. There was minimal binding of drug to RBCs. IV pharmacokinetics was characterized with a mean ± SD CL of 11.8 ± 7.4 mL/h and a Vss of 677 ± 229 L. 4. The double-tracer technique used in this study allowed to simultaneously characterize the absolute bioavailability and disposition characteristics of the new oral molecular entity in a single study.

O trabalho de enfermagem e o paciente terminal: possibilidades de uma convivência saudável com a morte / The nurse and the terminally ill patient: possibilities of healthy coexistence with death

Este artigo apresenta a atividade desenvolvida junto a uma equipe de enfermagem em uma unidade onde com freqüência internam pacientes terminais. O trabalho teve como objetivo avaliar como se dá a atuação da enfermagem diante do paciente terminal, tendo em vista uma convivência saudável com a morte. Na análise reflexiva sobre o tema estudado, pode-se perceber a necessidade de ampliar a abordagem acerca do cuidado prestado aos pacientes terminais, envolvendo basicamente o preparo da equipe que presta estes cuidados, apresentando como sugestão a implementação de grupos de estudo interdisciplinar...

This article presents an activity developed with a nursing team in a location where many terminally ill patients are often admitted. The purpose of this activity was to evaluate the nursing before the terminally ill patients in order to obtain healthy coexistence with the death. In the reflexive analysis about this theme, its noticed the need of amplifying the approach about the care given to the terminally ill patients, involving basically the team preparation that does this care, presenting as a suggestion the improvement of the interdiscipline study group...

Este artículo presenta la actividad desarrollada junto a un equipo de enfermerías e una unidad donde con frecuencia internan enfermos terminales. El trabajo tuvo como objetivo evaluar como actúa la enfermería ante el enfermo terminal para ayudarlo a convivir de forma saludable con la muerte. Reflexionando sobre el tema estudiado, se puede percibir la necesidad de ampliar el modo como se cuida de enfermo terminal, envolviendo básicamente la preparación del equipo que hace esos cuidados. Se presenta como sugerencia desarrollar la formación de grupos de estudios interdisciplinares...

Educadores-educandos construindo o projeto político-pedagógico de um curso centrado no cuidado cultural / Educators-learning building a political-pedagogical project for a course focused on cultural care

Apresenta a síntese do projeto político-pedagógico construído por um grupo de mestrandos. O trabalho constituiu-se num exercício acadêmico produzido nas disciplinas pedagógicas do curso e apresentado como contribuição da pós-graduação à graduação, visando subsidiar as discussões sobre a temática tão atual relevante. Está organizado sob a forma de marcos referencial, filosófico, conceitual e estrutural, integrados e orientados para um currículo fundamentado no cuidado cultural...

The synthesis of a political-pedagogical is presented, such as developed by a group of MarterÆs program students. The work was an academical exercise produced amidst the courses related to pedagogy and presented as a contribution of graduate to undergraduate programs in order to supply ways and means to conduct debates on such a current and relevant theme. The paper which is organized under the forma of reference, philosophical, conceptual and structural frameworks, is integrated and oriented towards a curriculum that is founded on cultural care...

Se presenta una síntesis del provecto político-pedagógico construido por un grupo de estudiantes de maestría. El trabajo se constituye en un ejercicio académico, producido en las disciplinas pedagógicas del curso, presentado como contribución del nivel de postgraduación al de graduación, buscando abrir discusiones sobre una temática actual y relevante. Su organización está sobre la forma de marcos referencial, filosófico, conceptual y estructural, integrados y orientados para un currículo fundamentado en el cuidado cultural...