RESUMO
BACKGROUND AND PURPOSE: The aim of this study was to evaluate and compare the fear of cancer recurrence (FCR) in patients diagnosed with a small renal mass (SRM) and managed with either active surveillance (AS) or minimal invasive renal cryoablation (CA). PATIENTS/MATERIAL AND METHODS: A total of 398 patients with SRMs (263 AS and 135 CA patients) were retrospectively identified across three institutions and invited to complete the Fear of Cancer Recurrence-Short Form (FCRI-SF) questionnaire. RESULTS: No statistically significant differences in FCRI-SF score were observed between the AS (mean = 10.9, standard deviation [SD] = 6.9) and CA (mean = 10.2, SD = 7.2) (p = 0.559) patients, with the mean scores of both groups being below the suggested clinically significant cut-off of 16. A total of 25% of AS and 28% of CA patients reported sub-clinical or clinical levels of FCR (FCRI-SF score > 16). Within the AS group, a weak negative association between FCR severity and age was observed (r = -0.23, p = 0.006), and a statistically significant difference in FCRI-SF score between patients aged more or less than 73 years (p = 0.009). INTERPRETATION: FCR levels were comparable between AS and CA patients, suggesting that treatment decisions should prioritise clinical factors. Up to 28% of AS and CA patients report clinically significant FCR, highlighting the importance of considering the possibility of FCR, especially in younger patients.
Assuntos
Criocirurgia , Medo , Neoplasias Renais , Recidiva Local de Neoplasia , Conduta Expectante , Humanos , Neoplasias Renais/cirurgia , Neoplasias Renais/patologia , Neoplasias Renais/psicologia , Masculino , Feminino , Idoso , Recidiva Local de Neoplasia/psicologia , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/epidemiologia , Estudos Retrospectivos , Medo/psicologia , Pessoa de Meia-Idade , Conduta Expectante/estatística & dados numéricos , Idoso de 80 Anos ou mais , Inquéritos e Questionários , Carcinoma de Células Renais/cirurgia , Carcinoma de Células Renais/patologia , Carcinoma de Células Renais/psicologia , AdultoAssuntos
Biópsia/métodos , Carcinoma in Situ/patologia , Carcinoma de Células de Transição/patologia , Cistoscopia , Recidiva Local de Neoplasia/patologia , Neoplasias da Bexiga Urinária/patologia , Bexiga Urinária/patologia , Urina/citologia , Adjuvantes Imunológicos/uso terapêutico , Administração Intravesical , Idoso , Idoso de 80 Anos ou mais , Vacina BCG/uso terapêutico , Carcinoma in Situ/terapia , Carcinoma in Situ/urina , Carcinoma de Células de Transição/terapia , Carcinoma de Células de Transição/urina , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico , Recidiva Local de Neoplasia/urina , Estudos Prospectivos , Neoplasias da Bexiga Urinária/terapia , Neoplasias da Bexiga Urinária/urina , Procedimentos Cirúrgicos UrológicosRESUMO
Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSA(PAM)). We report here that VSA(PAM)-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSA(PAM) expression in vitro.