Quench ionic flash nano precipitation as a simple and tunable approach to decouple growth and functionalization for the one-step synthesis of functional LnPO4-based nanoparticles in water.

A novel, one-step method for the synthesis of functional, organic-inorganic hybrid nanoparticles is reported. The quench ionic Flash NanoPrecipitation (qiFNP) method enables the straightforward synthesis of nanoparticles by decoupling the formation of the inorganic core and surface functionalization. As a proof-of-concept, the qiFNP method was successfully applied for the tunable and highly controlled synthesis of various LnPO4-based nanomaterials for bioimaging applications.