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1.
Kyobu Geka ; 61(5): 355-8, 2008 May.
Artigo em Japonês | MEDLINE | ID: mdl-18464477

RESUMO

An 82-year-old man developed simultaneous stent thrombosis 11 days after the implantation of a sirolimus-eluting stent (SES) in the proximal left anterior descending artery (LAD) and the proximal right coronary artery (RCA). The patient immediately underwent percutaneous coronary intervention; however, his condition became critical due to the development of recurrent stent thrombosis, and emergent coronary artery bypass grafting with saphenous vein grafts was performed. Postoperative angiography showed good patency of both grafts; thrombus formation in the LAD and RCA was negative. Since the patient had a history of liver dysfunction due to ticlopidine administration, the thienopyridine derivative was not administered; this was believed to be the main cause of subacute stent thrombosis. He was administered aspirin, cilostazol, and sarpogrelate instead. A good postoperative course was achieved only using aspirin. This case demonstrates that simultaneous SES thrombosis in multivessel lesions poses a life-threatening situation.


Assuntos
Ponte de Artéria Coronária , Trombose Coronária/etiologia , Trombose Coronária/cirurgia , Stents Farmacológicos/efeitos adversos , Sirolimo/administração & dosagem , Idoso de 80 Anos ou mais , Angina Pectoris/terapia , Aspirina/administração & dosagem , Reestenose Coronária/etiologia , Emergências , Humanos , Masculino , Inibidores da Agregação Plaquetária/administração & dosagem , Resultado do Tratamento
2.
Kyobu Geka ; 60(2): 97-101, 2007 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-17305073

RESUMO

We report a case of emergent coronary artery bypass grafting (CABG) in a survivor of an out-of-hospital cardiac arrest. A 64-year-old male driver lost consciousness and collapsed in a rice paddy field. A bystander placed him in a car and immediately started cardiopulmonary resuscitation after confirming the presence of pulselessness and apnea. Emergency medical service providers performed a defibrillation of ventricular fibrillation by using an automated external defibrillator (AED), and the patient was transferred to the critical care center in our hospital. Coronary angiography revealed a thrombus in the left main trunk (LMT), total occlusion of the left anterior descending artery (LAD) and the right coronary artery (RCA), and 90% stenosis of the left circumflex artery (Cx). Since the patient recovered consciousness 1 hour after admission and did not undergo any critical trauma, an on-pump CABG was performed for 3 vessels. He was discharged on the postoperative day 23, and he resumed a normal life.


Assuntos
Reanimação Cardiopulmonar , Ponte de Artéria Coronária , Serviços Médicos de Emergência , Parada Cardíaca/cirurgia , Balão Intra-Aórtico , Eletrocardiografia , Humanos , Masculino , Pessoa de Meia-Idade , Sobreviventes , Fibrilação Ventricular/cirurgia
3.
Brain Res ; 918(1-2): 131-40, 2001 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-11684051

RESUMO

The predictive value of increase in cerebral blood flow (CBF) was examined to detect hyperbaric oxygen (HBO(2))-induced electrical discharge in artificially ventilated rats at three PaCO(2) levels under 5 atmospheric pressures. The possible involvement of NO production in the mechanism of the increase in CBF was also assessed by measurement of major NO metabolites (NO(2)(-) plus NO(3)(-)) using a microdialysis technique at the left parietal cortex during HBO(2) exposure. The onset times of electrical discharge, measured in the right frontal region, were significantly prolonged and shortened in the low PaCO(2) group (79+/-21 min) and high PaCO(2) group (27+/-7 min), respectively, compared to that in the normal PaCO(2) group (37+/-5 min). Increase in CBF (200% of the pre-exposure level) was observed in every animal and was sustained until the appearance of electrical discharge. The onset time of increase in CBF was closely related to that of electrical discharge (R(2)=0.987), and the durations of increase in CBF were almost identical (11-14 min in mean) regardless of the PaCO(2) level. The level of NO(2)(-) plus NO(3)(-) was unaffected by the initiation of HBO(2) exposure and simultaneously increased up to 246+/-59% of control level with the onset of increase in CBF. There was a close relationship between changes in CBF and levels of NO(2)(-) plus NO(3)(-) (R(2)=0.544). These results indicate that monitoring of CBF is useful for the prediction of electrical discharge in artificially ventilated rats regardless of their PaCO(2) levels and that the increase in NO production is related to the mechanism of increase in CBF.


Assuntos
Encéfalo/efeitos dos fármacos , Circulação Cerebrovascular/efeitos dos fármacos , Oxigenoterapia Hiperbárica/efeitos adversos , Hiperóxia/metabolismo , Óxido Nítrico/biossíntese , Oxigênio/toxicidade , Convulsões/induzido quimicamente , Animais , Encéfalo/metabolismo , Encéfalo/fisiopatologia , Dióxido de Carbono/metabolismo , Circulação Cerebrovascular/fisiologia , Eletroencefalografia/efeitos dos fármacos , Espaço Extracelular/efeitos dos fármacos , Espaço Extracelular/metabolismo , Hiperóxia/fisiopatologia , Masculino , Potenciais da Membrana/efeitos dos fármacos , Potenciais da Membrana/fisiologia , Microdiálise , Ratos , Ratos Wistar , Convulsões/metabolismo , Convulsões/fisiopatologia
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