Biophysical Reviews: a transition in the journal.

This Editorial for Volume 16 Issue 2 first describes the issue contents before describing some upcoming events within Biophysical Reviews and concludies with an announcement on the transition of Chief Editors thanks to the outgoing Chief Editor.

Biophysical Reviews: peering into 2024.

After introducing the winner of this year's Michèle Auger Award for Young Scientists' Independent Research, this Editorial for Volume 16 Issue 1 then describes the Issue contents. The Editorial concludes by providing a look into what lies ahead for 2024.

Biophysical reviews Special issue call: The 21st IUPAB Congress 2024 Kyoto Japan.

This commentary describes an open call for submissions to the upcoming Biophysical Reviews' Special Issue: The 21st IUPAB Congress 2024 Kyoto Japan. The submission deadline is July 1st of 2024. Interested parties are requested to make contact with the Special Issue editors prior to submission.

Equations describing semi-confluent cell growth (I) Analytical approximations.

A set of differential equations with analytical solutions are presented that can quantitatively account for variable degrees of contact inhibition on cell growth in two- and three-dimensional cultures. The developed equations can be used for comparative purposes when assessing contribution of higher-order effects, such as culture geometry and nutrient depletion, on mean cell growth rate. These equations also offer experimentalists the opportunity to characterize cell culture experiments using a single reductive parameter.

HSAFM-MIREBA - Methodology for Inferring REsolution in biological applications.

Due to a lack of requirement for any direct labelling of the target molecule, high speed atomic force microscopy (HS-AFM) is a potentially powerful procedure for the assessment of biological processes involving macromolecules. When the sample is static the AFM device can be purposefully setup to recover high-resolution information about the feature in question. However, when the feature to be studied moves an appreciable amount during the course of the measurement, the obtained image will be blurred. Encountering such blurred observations prompts the experimenter to sacrifice higher resolution images for higher scanning speeds by tuning available experimental parameters (such as the scanned image area, the image pixel size, the resonance frequency of the cantilever and/or the diameter of the AFM tip). The present work describes a software tool, HSAFM-MIREBA (High Speed Atomic Force Microscopy - Methodology for Inferring REsolution in Biological Applications) that allows for pre-experimental optimization of such parameters through iterative rounds of simulation of both the dynamic surface process and the HS-AFM measurement (based on the particular set of governing parameters). A representative set of five dynamic biological processes that describe a range of diffusive and directed motions (which can themselves be tuned by altering characteristic governing parameter sets) are provided.

MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission.

The single-celled baker's yeast, Saccharomyces cerevisiae, can sustain a number of amyloid-based prions, the three most prominent examples being [URE3], [PSI+], and [PIN+]. In the laboratory, haploid S. cerevisiae cells of a single mating type can acquire an amyloid prion in one of two ways (i) spontaneous nucleation of the prion within the yeast cell, and (ii) receipt via mother-to-daughter transmission during the cell division cycle. Similarly, prions can be lost due to (i) dissolution of the prion amyloid by its breakage into non-amyloid monomeric units, or (ii) preferential donation/retention of prions between the mother and daughter during cell division. Here we present a computational tool (Monitoring Induction and Loss of prions in Cells; MIL-CELL) for modelling these four general processes using a multiscale approach describing both spatial and kinetic aspects of the yeast life cycle and the amyloid-prion behavior. We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chronological and reproductive age also makes MIL-CELL potentially useful in studies of cell aging.

Editors' Roundup: June 2023.

This commentary article represents the latest edition of the Biophysical Reviews 'Editors' Roundup' Series - a platform made available to the editorial board members of any journal with a genuine interest in promoting biophysical content. Each journal associated editor is able to submit a short description of up to five articles recently appearing in their journals with an explanation of why these articles are of interest. This edition (Vol. 15 Issue 3 June 2023) carries contributions from editorial members associated with Biophysics and Physicobiology (Biophysical Society of Japan), Biophysics (Russian Academy of Sciences), Cell Biochemistry and Biophysics (Springer), and Biophysical Reviews (IUPAB-International Union for Pure and Applied Biophysics).

Biophysical Reviews: a call for nominations to the 2024 Michéle Auger Award.

This editorial for volume 15 issue 3 first provides a brief introduction to the issue contents before then going on to open the call for nominations to the 2024 Michéle Auger Award for Young Scientists' Independent Research-the journal's single award.

Biophysical Reviews: And the winner is .

This Editorial (Vol. 15 Issue 2-Regular Issue) first announces the winner of the 2023 Michèle Auger Award for Young Scientists' Independent Research before then going on to describe the contents of the current Issue. The Editorial closes with a discussion of the pros and cons of writing in the formulation of scientific ideas.

Editors' roundup: April 2023.

The IUPAB Biophysical Reviews journal provides a regular forum, known as the "Editors' Roundup," that is available to editorial board members of any biophysics-related journal to contribute a personal recommendation of articles appearing within their publications. This latest Issue of the Editors' Roundup carries recommendations from editorial board members associated with the following journals, Cell Biochemistry and Biophysics, Biophysics, and the Biophysical Reviews journal.

Biophysical Reviews Issue Focus call: Computational biophysics of atomic force microscopy.

This Commentary describes an open call for submissions to an Issue Focus of the IUPAB Biophysical Reviews journal on the topic of the, 'Computational biophysics of atomic force microscopy'. The Issue Focus will be published in Volume 15 Issue 6 of Biophysical Reviews in late December of 2023. The submission deadline is September 1st of 2023. Interested parties are requested to contact the Special Issue Editors prior to submission.

Biophysical Reviews: Turning the page from 2022 to 2023.

This Editorial (vol. 15 issue 1-Regular Issue featuring an Issue Focus on the "100th Anniversary of Har Gobind Khorana") first describes the issue contents before providing both, a look back at some journal highlights from 2022, and a look forward to what we can expect from 2023. The Editorial closes with a roundup of new journal access features and an acknowledgement of those supporting the journal.

Correction to: Biophysical Reviews: Publishing short and critical reviews written by key figures in the field.

[This corrects the article DOI: 10.1007/s12551-022-01009-6.].

Computational biophysics of atomic force microscopy-an IUPAB-sponsored workshop.

Atomic Force Microscopy (AFM) is a structural determination technique that involves 'prodding' surfaces with a nanometer sized needle with concomitant measurement of the resisting force. Due to its ability to interrogate the nanometer-to-micrometer size range, AFM is especially suited to the structural analysis of everything from biopolymers to cells and, as such, has become an important biophysical method. As AFM was only invented in 1986 it is relatively less scientifically developed than other structural techniques, such as NMR, X-ray crystallography and electron microscopy, that have a longer history of usage. In September of 2022 the first workshop of its kind was held to examine modern computational methods useful for simulating and analysing bioAFM experiments. Sponsored by a small IUPAB workshop grant, the three day meeting was of the hybrid (joint online /in person) type and had presenting participants based in Australia, UK, Finland, Thailand, South Korea, Vietnam and Japan. Each invited speaker was asked to deliver a lecture composed of half educational material (pitched at the level of an advanced postgraduate student) and half cutting edge research material (gathered from their own studies). IUPAB funds were used to invite young researchers (postgraduate students and early career scientists) from both within Japan and countries in the near asian region who had an interest in learning about the theoretical and experimental basis of the AFM technique. This Editorial describes the workshop and introduces the written contributions from the invited lecturers.

Biophysical Reviews: A goodbye to 2023.

This Editorial for the IUPAB Biophysical Reviews journal (2023 volume 15 issue 6) first provides an overview of the contents of this "Regular Issue featuring an Issue Focus on the Computational Biophysics of Atomic Force Microscopy" before going on to highlight some of the notable work published in the journal throughout 2023. Highlights of the current Issue include the contributed review article by Antonio Benedetto, winner of the 2023 Michèle Auger Award for Young Scientists' Independent Research, the latest installment of the "Biophysical Reviews Top 5 Series" authored by Angela Dulhunty, and an Issue Focus on the topic of computational aspects of atomic force microscopy generated from an IUPAB-sponsored workshop held in 2022.

Biophysical Reviews' "Meet the Editors Series": a profile of Damien Hall.

This piece introduces Damien Hall, Chief Editor of the Biophysical Reviews journal since 2019. Currently working as an Assistant Professor at Kanazawa University, the author describes his association with the journal along with some parts of his family history and academic journey.

Simulating biological surface dynamics in high-speed atomic force microscopy experiments.

High-speed atomic force microscopy (HSAFM) is an important tool for studying the dynamic behavior of large biomolecular assemblies at surfaces. However, unlike light microscopy techniques, which visualize each point in the field of view at the same time, in HSAFM, the surface is literally imaged pixel-by-pixel with a variable extent of time separation existing between recordings made at one pixel and all others within the surface image. Such "temporal asynchronicity" in the recording of the spatial information can introduce distortions into the image when the surface components move at a rate comparable to that at which the surface is imaged. This Letter describes recently released software developments that are able to predict the likely form of these distortions and estimate confidence levels when assigning the identity of observed structures. These described approaches may facilitate both the design and optimization of future HSAFM experimental protocols. Further to this, they may assist in the interpretation of results from already published HSAFM studies.

Editors' roundup: October 2022.

This commentary constitutes the October edition of the 'Editors' roundup'-a multi-author omnibus of personal recommendations to interesting biophysics-related articles contributed by members of the editorial boards of leading international biophysics journals. The present commentary contains contributions from Progress in Biochemistry and Biophysics (an official journal of the Biophysical Society of China), European Biophysics Journal (the official journal of the European Biophysical Societies Association), Biophysical Reviews (the official IUPAB journal), and Biophysics (an official journal of the Russian Academy of Sciences). This edition of the Editors' Roundup also contains a new section from an editor at large who has provided selections from a number of journals on a single thematic topic.

Biophysical Reviews: Publishing short and critical reviews written by key figures in the field.

This Editorial for Issue 5 (Vol. 14 2022) of Biophysical Reviews begins with a short note of commemoration for the journal's founding chief editor Jean Garnier (1929-2022) who sadly passed away this month. Following this is a precis of the current Issue contents that begins with an introduction of the prizewinning article by Assoc. Prof. Miho Yanagisawa, winner of the 2022 Michèle Auger Award for Young Scientists' Independent Research. This Editorial concludes with a brief and somewhat subjective discussion of what features do and don't, help to make for a 'good journal'.

Editors' Roundup: June 2022.

This Commentary describes the June 2022 installment of the "Editors' Roundup" feature. The Editors' Roundup is a multi-author collective description of recently published biophysical research contributed by editorial board members of different journals with a bonafide interest in publishing biophysical content. This Commentary contains a series of personal recommendations for articles appearing in the following journals, Biophysics and Physicobiology, European Biophysics Journal, Cell Biochemistry and Biophysics, and Biophysical Reviews.