RESUMO
Fulminating gold, the first high-explosive compound to be discovered, disintegrates into a mysterious cloud of purple smoke, the nature of which has been speculated upon since its discovery in the 15th century. In this work, we show that the colour of the smoke is due to the presence of gold nanoparticles.
RESUMO
Savolitinib is a compound that can crystallize in an undesirable, high aspect ratio needle morphology. This morphology type may cause issues in downstream processing. This paper demonstrates a unique method to alter the crystal morphology of savolitinib to make it more processable, resulting in the active pharmaceutical ingredient (API) crystallizing out in considerably more processable stellates. The volatile deep eutectic solvent technique presents a simple and scalable method for changing the crystal morphology while maintaining the polymorph of the API in this case, confirmed via powder X-ray diffraction and differential scanning calorimetry analysis.
RESUMO
The synthesis of corundum (α-Al2O3) via a layered Al2O3-MoO3 system was directly observed for the first time. This revealed a new crystal growth process with three key features: (1) the formation of an Al2(MoO4)3 intermediate layer through a solid-solid interaction in the temperature range of â¼705-860 °C; (2) the melting of the Al2(MoO4)3 layer between approximately 870 and 890 °C; and (3) the decomposition of Al2(MoO4)3 to corundum between 950 and 1100 °C. This molten intermediate decomposition (MIND) mechanism produced corundum, which was light bluish-gray in color and was defined in CIE (L* a* b*) color space as L* = 76.65, a* = -1.09, and b* = -6.20. The reagents used in this study were the same as those used in MoO3 flux growth studies on the synthesis of corundum, therefore demonstrating that the previous work only gave a superficial treatment of the mechanism of formation.