[Sublingual hyposensitization]. / L'hyposensibilisation par voie sublinguale.

Specific hyposensitization remains the only way to alter profoundly the progress of the allergic disease. The last discoveries in immunology allow better to understand the mechanisms of action. Now, we can use more purified and standardised solutions to improve the results. Subcutaneous way remains the gold method. But, since 10 years, European screws publishes the results of their works about alternative ways like sublingual way. Less dangerous and less compelling, it allows to begin the treatment earlier in the live and to give more important doses. The results are equivalent to the subcutaneous method. Recently, W.H.O. decided to consider sublingual immunotherapy as un full treatment of some allergic diseases.

Changes in regional and overall lung function after bronchography.

This investigation compares the effects of unilateral bronchography on classical pulmonary function parameters (spirometry, CO transfer, flow-volume curve, and arterial blood gases) and radioisotopic measurements by means of 99mTc-labeled microspheres and 81mKr. The regional changes of ventilation and perfusion were quantified by a radioisotopic index, which was established for each zone of interest: explored lung and unexplored lung. The quantitative study of regional perfusion and ventilation reveals significant reduction of ventilation for lung bases, but not for lung apices. The radioisotopic measurements show a reduction of perfusion parallel to the reduction of ventilation. There is no significant correlation between traditional pulmonary function parameters and isotopic indices. Radioisotopy proved a sensitive tool for investigation of unilateral alterations.