RESUMO
Patient-specific modeling of ventricular electrophysiology requires an interpolated reconstruction of the 3-dimensional (3D) geometry of the patient ventricles from the low-resolution (Lo-res) clinical images. The goal of this study was to implement a processing pipeline for obtaining the interpolated reconstruction, and thoroughly evaluate the efficacy of this pipeline in comparison with alternative methods. The pipeline implemented here involves contouring the epi- and endocardial boundaries in Lo-res images, interpolating the contours using the variational implicit functions method, and merging the interpolation results to obtain the ventricular reconstruction. Five alternative interpolation methods, namely linear, cubic spline, spherical harmonics, cylindrical harmonics, and shape-based interpolation were implemented for comparison. In the thorough evaluation of the processing pipeline, Hi-res magnetic resonance (MR), computed tomography (CT), and diffusion tensor (DT) MR images from numerous hearts were used. Reconstructions obtained from the Hi-res images were compared with the reconstructions computed by each of the interpolation methods from a sparse sample of the Hi-res contours, which mimicked Lo-res clinical images. Qualitative and quantitative comparison of these ventricular geometry reconstructions showed that the variational implicit functions approach performed better than others. Additionally, the outcomes of electrophysiological simulations (sinus rhythm activation maps and pseudo-ECGs) conducted using models based on the various reconstructions were compared. These electrophysiological simulations demonstrated that our implementation of the variational implicit functions-based method had the best accuracy.
Assuntos
Mapeamento Potencial de Superfície Corporal/métodos , Sistema de Condução Cardíaco/patologia , Sistema de Condução Cardíaco/fisiopatologia , Ventrículos do Coração/patologia , Ventrículos do Coração/fisiopatologia , Imageamento Tridimensional/métodos , Pontos de Referência Anatômicos/patologia , Animais , Cães , Humanos , Interpretação de Imagem Assistida por Computador/métodos , Imagem Multimodal/métodos , Modelagem Computacional Específica para o Paciente , SuínosRESUMO
The presence of pacemakers and implantable cardioverter-defibrillators (ICD) is considered historically a contraindication to magnetic resonance (MR) imaging. This image modality has unparalleled soft-tissue imaging capabilities, and many consider it as the image of choice for patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). ICDs are now smaller, with less magnetic materials and improved electromagnetic interference protection. We tested modern ICDs for heat, force, function and image distortion and found that several of them may indeed be MRI safe. We report here a patient who was suspected of ARVD/C, underwent ICD implantation based on MR safety testing, and underwent intentionally scheduled follow-up cardiac MR imaging. This is the description of a patient with an ICD who had planned MRI scanning. The scan was safe and most of the MRI images were of high quality.
Assuntos
Desfibriladores Implantáveis/efeitos adversos , Segurança de Equipamentos , Imageamento por Ressonância Magnética , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/terapia , Adulto , HumanosRESUMO
BACKGROUND: There is increasing evidence that defibrillation from prolonged ventricular fibrillation (VF) before CPR decreases survival. It remains unclear, however, whether harmful effects are due primarily to initial countershock of ischemic myocardium or to resultant postdefibrillation rhythms (ie, pulseless electrical activity [PEA] or asystole). METHODS AND RESULTS: We induced 15 dogs into 12 minutes of VF and randomized them to 3 groups. Group 1 was defibrillated at 12 minutes and then administered advanced cardiac life support (ACLS); group 2 was allowed to remain in VF and was subsequently defibrillated after 4 minutes of ACLS; group 3 was defibrillated at 12 minutes, electrically refibrillated, and then defibrillated after 4 minutes of ACLS. All group 1 and 3 animals were defibrillated into PEA/asystole at 12 minutes. After 4 minutes of ACLS, group 2 and 3 animals were effectively defibrillated into sinus rhythm. The extension of VF in group 2 and 3 subjects paradoxically resulted in shorter mean resuscitation times (251+/-15 and 245+/-7 seconds, respectively, versus 459+/-66 seconds for group 1; P<0.05) and improved 1-hour survival (10 of 10 group 2 and 3 dogs versus 1 of 5 group 1 dogs; Fisher's exact, P<0.005) compared with more conservatively managed group 1 subjects. CONCLUSIONS: Precountershock CPR during VF appears more conducive to resuscitation than CPR during postcountershock PEA or asystole. The intentional induction of VF may prove useful in the management of PEA and asystolic arrests.
Assuntos
Reanimação Cardiopulmonar , Parada Cardíaca/fisiopatologia , Fibrilação Ventricular/fisiopatologia , Animais , Cães , Cardioversão Elétrica , Estimulação Elétrica , Parada Cardíaca/prevenção & controle , Ventrículos do Coração/fisiopatologia , Hemodinâmica/fisiologia , Fatores de Tempo , Disfunção Ventricular Esquerda/fisiopatologia , Fibrilação Ventricular/terapiaRESUMO
The purpose of this prospective randomized study was to compare the safety and efficacy of the cephalic approach versus a contrast-guided extrathoracic approach for placement of endocardial leads. Despite an increased incidence of lead fracture, the intrathoracic subclavian approach remains the dominant approach for placement of pacemaker and implantable defibrillator leads. Although this complication can be prevented by lead placement in the cephalic vein or by lead placement in the extrathoracic subclavian or axillary vein, these approaches have not gained acceptance. A total of 200 patients were randomized to undergo placement of pacemaker or implantable defibrillator leads via the contrast-guided extrathoracic subclavian vein approach or the cephalic approach. Lead placement was accomplished in 99 of the 100 patients randomized to the extrathoracic subclavian vein approach as compared to 64 of 100 patients using the cephalic approach. In addition to a higher initial success rate, the extrathoracic subclavian vein medial approach was determined to be preferable as evidenced by a shorter procedure time and less blood loss. There was no difference in the incidence of complications. In conclusion, these results demonstrate that lead placement in the extrathoracic subclavian vein guided by contrast venography is effective and safe. It was also associated with no increased risk of complications as compared with the cephalic approach. These findings suggest that the contrast-guided approach to the extrathoracic portion of the subclavian vein should be considered as an alternative to the cephalic approach.
Assuntos
Desfibriladores Implantáveis , Eletrodos Implantados , Marca-Passo Artificial , Flebografia , Idoso , Idoso de 80 Anos ou mais , Análise de Falha de Equipamento , Segurança de Equipamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculos Peitorais/irrigação sanguínea , Estudos Prospectivos , Veia Subclávia/diagnóstico por imagem , Resultado do TratamentoRESUMO
BACKGROUND AND OBJECTIVE: Focal sources of paroxysmal atrial fibrillation may be treatable by electrical isolation of the pulmonary veins from the left atrium. A new fiberoptic balloon catheter was tested as an alternative to radiofrequency catheter ablation for creation of circumferential thermal lesions at the pulmonary vein orifice. STUDY DESIGN/MATERIALS AND METHODS: In vitro and in vivo experiments were conducted in canine hearts to demonstrate efficacy and optimize ablation dosimetry. Continuous-wave, 1.06-microm, Nd:YAG laser radiation was delivered radially through diffusing optical fiber tips enclosed in a balloon catheter. During in vivo studies, the catheter was placed at the pulmonary vein orifice through a left atrial appendage sheath under X-ray fluoroscopic guidance during an open-chest procedure. Additionally, circumferential lesions in the left atrial appendage were correlated with epicardial electrograms demonstrating elimination of electrical activity. RESULTS: The pulmonary veins were successfully ablated by using laser powers of 30--50 W and irradiation times of 60--90 seconds. Transmural, continuous, and circumferential lesions were produced in the pulmonary veins in a single application without evidence of tissue vaporization or endothelial disruption. CONCLUSION: Laser ablation by using a fiberoptic balloon catheter may represent a promising alternative to radiofrequency catheter ablation for electrical isolation of the pulmonary veins from the left atrium during treatment of paroxysmal atrial fibrillation. Further development and testing of the fiberoptic catheter is warranted for possible clinical studies.
Assuntos
Ablação por Cateter/instrumentação , Terapia a Laser , Veias Pulmonares/cirurgia , Taquicardia Paroxística/cirurgia , Animais , Fibrilação Atrial/complicações , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/cirurgia , Ablação por Cateter/métodos , Técnicas de Cultura , Modelos Animais de Doenças , Cães , Relação Dose-Resposta à Radiação , Eletrocardiografia , Tecnologia de Fibra Óptica , Neodímio , Fibras Ópticas , Valores de Referência , Sensibilidade e Especificidade , Taquicardia Paroxística/complicaçõesAssuntos
Reanimação Cardiopulmonar/instrumentação , Reanimação Cardiopulmonar/normas , Parada Cardíaca/terapia , Desenho de Equipamento , Segurança de Equipamentos , Equipamentos e Provisões , Medicina Baseada em Evidências , Parada Cardíaca/mortalidade , Humanos , Análise de Sobrevida , Fatores de Tempo , Resultado do TratamentoAssuntos
Reanimação Cardiopulmonar , Serviços Médicos de Emergência , Parada Cardíaca/terapia , Guias de Prática Clínica como Assunto , Suporte Vital Cardíaco Avançado , Algoritmos , American Heart Association , Antiarrítmicos/uso terapêutico , Reanimação Cardiopulmonar/normas , Cardioversão Elétrica , Serviços Médicos de Emergência/normas , Epinefrina/uso terapêutico , Medicina Baseada em Evidências , Humanos , Respiração Artificial , Simpatomiméticos/uso terapêutico , Estados Unidos , Vasoconstritores/uso terapêutico , Vasopressinas/uso terapêuticoRESUMO
Improved blood flow during cardiopulmonary resuscitation (CPR) has been shown to enhance survival from cardiac arrest. Chest compression with a circumferential pneumatic vest enhances blood flow, but the size, weight, and energy consumption of the inflation system limit its portability and, thereby, have made clinical studies difficult. The purpose of this investigation was to study an improved circumferential chest compression device that uses a constricting band that is pneumatically actuated. The constricting band applies its force to a hydraulic cushion that contacts the anterior and lateral aspects of the chest. The hydraulic cushion transfers the circumferential constriction to inward force. CPR was performed on subjects 5 mins after induction of ventricular fibrillation, with the hydraulic-pneumatic band system (HB-CPR), with a pneumatic vest system (PV-CPR), and with standard manual CPR (S-CPR), each done for 2 mins in randomized order. Aortic and right atrial pressures were measured with micromanometers. Coronary perfusion pressure was calculated as the mean difference between the aortic and right atrial pressures during the release phase of chest compression. Aortic pressure and coronary perfusion pressure with HB-CPR and PV-CPR were improved over S-CPR, and HB-CPR produced comparable pressures to those of PV-CPR. The system for performing HB-CPR, however, was substantially lighter (10 vs. 50 kg) and consumed less energy (300 vs. 1000 watts) than that for PV-CPR. Thus, HB-CPR appears to produce a similar improvement in hemodynamics over S-CPR as PV-CPR but may be more portable than PV-CPR. Therefore, HB-CPR may allow larger scale testing of circumferential chest compression approaches.
Assuntos
Bandagens , Reanimação Cardiopulmonar/instrumentação , Parada Cardíaca/terapia , Animais , Vestuário , Cães , Desenho de Equipamento , Humanos , Suínos , TóraxRESUMO
BACKGROUND AND OBJECTIVE: Linear lesions may be necessary for successful catheter ablation of cardiac arrhythmias such as atrial fibrillation. This study uses laser energy delivered through diffusing optical fibers as an alternative to radiofrequency energy for the creation of linear lesions in cardiac tissue in a single application. STUDY DESIGN/MATERIALS AND METHODS: Samples of canine myocardium were placed in a heated, circulating saline bath and irradiated with a 1.06-microm, continuous-wave Nd:YAG laser during in vitro studies. Laser ablation was then performed in vivo on the epicardial surface of the right ventricle during an open-chest procedure by using similar ablation parameters. Laser energy was delivered to the tissue by being diffused radially through flexible optical fiber tips oriented parallel to the tissue surface. Histology and temperature measurements verified transmurality, continuity, and linearity of the lesions. RESULTS: Peak tissue temperatures measured in vitro remained low (51 +/- 1 degrees C at the endocardial surface, 61 +/- 6 degrees C in the mid-myocardium, and 55 +/- 6 degrees C at the epicardial surface) with no evidence of tissue charring or vaporization. Lesion dimensions produced in vitro and in vivo were similar (depth, 6 mm; width, 8-10 mm; length, 16-22 mm), demonstrating that tissue perfusion in vivo did not significantly alter the heating. CONCLUSION: Long linear lesions, necessary for duplication of the surgical maze procedure during catheter ablation of atrial fibrillation, may be created by using laser radiation delivered through flexible diffusing optical fiber tips. Further development of steerable catheters for endocardial atrial ablation and studies correlating thermal damage zones with electrophysiologic indicators of irreversible conduction block are warranted.
Assuntos
Fibrilação Atrial/cirurgia , Ablação por Cateter/métodos , Terapia a Laser , Animais , Temperatura Corporal , Cães , Tecnologia de Fibra Óptica/instrumentação , Terapia a Laser/instrumentação , Fibras Ópticas , Pericárdio/cirurgiaRESUMO
BACKGROUND: The purpose of this study was to describe a system and method for creating, visualizing, and monitoring cardiac radiofrequency ablation (RFA) therapy during magnetic resonance imaging (MRI). METHODS AND RESULTS: RFA was performed in the right ventricular apex of 6 healthy mongrel dogs with a custom 7F nonmagnetic ablation catheter (4-mm electrode) in a newly developed real-time interactive cardiac MRI system. Catheters were positioned to intracardiac targets by use of an MRI fluoroscopy sequence, and ablated tissue was imaged with T2-weighted fast spin-echo and contrast-enhanced T1-weighted gradient-echo sequences. Lesion size by MRI was determined and compared with measurements at gross and histopathological examination. Ablated areas of myocardium appeared as hyperintense regions directly adjacent to the catheter tip and could be detected 2 minutes after RF delivery. Lesions reached maximum size approximately 5 minutes after ablation, whereas lesion signal intensity increased linearly with time but then reached a plateau at 12.2+/-2.1 minutes. Lesion size by MR correlated well with actual postmortem lesion size and histological necrosis area (55.4+/-7.2 versus 49.7+/-5.9 mm(2), r=0.958, P<0.05). CONCLUSIONS: RFA can be performed in vivo in a new real-time interactive cardiac MRI system. The spatial and temporal extent of cardiac lesions can be visualized and monitored by T2- and T1-weighted imaging, and MRI lesion size agrees well with actual postmortem lesion size. MRI-guided RFA may be a useful approach to help facilitate anatomic lesion placement and to provide insight into the biophysical effects of new ablation techniques and technologies.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Ablação por Cateter , Imageamento por Ressonância Magnética , Miocárdio/patologia , Animais , Cadáver , Cães , Necrose , Período Pós-Operatório , Fatores de TempoRESUMO
BACKGROUND: Survival after prolonged ventricular fibrillation (VF) appears severely limited by 2 major factors: (1) low defibrillation success rates and (2) persistent post-countershock myocardial dysfunction. Biphasic (BP) waveforms may prove capable of favorably modifying these limitations. However, they have not been rigorously tested against monophasic (MP) waveforms in clinical models of external defibrillation, particularly where rescue from prolonged VF is the general rule. METHODS AND RESULTS: We randomized 26 dogs to external countershocks with either MP or BP waveforms. Hemodynamics were assessed after shocks applied during sinus rhythm, after brief VF (>10 seconds), and after resuscitation from prolonged VF (>10 minutes). Short-term differences in percent change in left ventricular +dP/dt(max) (MP -16+/-28%, BP +9.1+/-24%; P=0.03) and left ventricular -dP/dt(max) (MP -37+/-26%, BP -18+/-20%; P=0.05) were present after rescue from brief VF, with BP animals exhibiting less countershock-induced dysfunction. After prolonged VF, the BP group had lower mean defibrillation thresholds (107+/-57 versus 172+/-88 J for MP, P=0.04) and significantly shorter resuscitation times (397+/-73.7 versus 488+/-74.3 seconds for MP, P=0.03). CONCLUSIONS: External defibrillation is more efficacious with BP countershocks than with MP countershocks. The lower defibrillation thresholds and shorter resuscitation times associated with BP waveform defibrillation may improve survival after prolonged VF arrest.
Assuntos
Cardioversão Elétrica/métodos , Ressuscitação , Fibrilação Ventricular/terapia , Animais , Pressão Sanguínea , Cardiomiopatias/etiologia , Cardiomiopatias/fisiopatologia , Circulação Coronária , Cães , Cardioversão Elétrica/efeitos adversos , Cardioversão Elétrica/normas , Coração/fisiopatologia , Parada Cardíaca/terapia , Fatores de TempoRESUMO
The aim of this study was to compare the lesions created using a multipolar microcatheter (MICRO) ablation system in the right canine atrium to a pullback approach with a standard radiofrequency (STND RF) ablation and to determine the value of electrogram amplitude and pacing threshold in predicting transmurality of lesions. Ten dogs underwent right atrial ablation using a MICRO (6 dogs) or STND RF (4 dogs) ablation system in each animal. Attempts were made to create linear RF lesions at four predetermined atrial sites. RF energy was delivered for 60 seconds using closed-loop, temperature control to achieve a target temperature of 60 degrees C for STND RF and 50 degrees C for MICRO. Unipolar atrial electrogram amplitude and atrial pacing threshold were obtained before and after ablation. Pathological analysis was determined at 4 weeks after ablation. Lesions created with MICRO were narrower, more likely to be continuous, and more likely to be anchored to an anatomic structure than those lesions which were created using a STND RF. No difference was observed in overall lesion length or in the proportion of lesions that were transmural over at least 50% of their length. Of lesions created using MICRO, a significant relation was observed between transmurality of lesion and unipolar electrogram amplitude as well as pacing threshold. Further studies are needed to determine if this type of ablation technique and parameters during ablation may facilitate a successful catheter-based MAZE procedure.
Assuntos
Ablação por Cateter/métodos , Animais , Fibrilação Atrial/patologia , Fibrilação Atrial/terapia , Estimulação Cardíaca Artificial , Cães , Eletrocardiografia , Seguimentos , Átrios do Coração/patologia , Estudos ProspectivosRESUMO
A viscoelastic model developed to model human sternal response to the cyclic loading of manual cardiopulmonary resuscitation (CPR) [8] was used to evaluate the properties of canine chests during CPR. Sternal compressions with ventilations after every fifth compression were applied to supine canines (n = 7) with a mechanical resuscitation device. The compressions were applied at a nominal rate of 90/min with a peak force near 400 N. From measurements of sternal force, sternal displacement, and tracheal airflow, model parameters were estimated and their dependence on time and lung volume evaluated. The position to which the chest recoiled between compressions changed with time at a mean rate of 1.0 mm/min. Within each ventilation cycle (five compressions) the sternal recoil position decreased by 2.0 cm for each liter of decrease in lung volume. The elastic force and damping decreased with time and decreasing lung volume. Canine and human [8] model parameters were found to be similar despite the notable differences in thoracic anatomy between the species, supporting the continued use of canines as models for human CPR. These parameters may be useful in the development of a model relating sternal compression forces to blood flow during CPR.
Assuntos
Reanimação Cardiopulmonar , Esterno/fisiologia , Animais , Cães , Elasticidade , Humanos , Medidas de Volume Pulmonar , Modelos Anatômicos , Pressão , Especificidade da Espécie , Esterno/irrigação sanguínea , Decúbito Dorsal , Tórax/fisiologia , Fibrilação Ventricular/terapia , Suporte de CargaRESUMO
A method for imaging the rapid temporal-spatial evolution of myocardial deformations in the paced heart is proposed. High time resolution-tagged MR images were obtained after stimulation of the myocardium with an MR-compatible pacing system. The images were analyzed to reconstruct dynamic models of local 3D strains over the entire left ventricle during systole. Normal canine hearts were studied in vivo with pacing sites on the right atrium, left ventricular free wall and right ventricular apex. This method clearly resolved local variations in myocardial contraction patterns caused by ventricular pacing. Potential applications are noninvasive determination of electrical conduction abnormalities and the evaluation of new pacing therapies.
Assuntos
Estimulação Cardíaca Artificial , Átrios do Coração/patologia , Ventrículos do Coração/patologia , Imageamento por Ressonância Magnética/métodos , Animais , Cães , Átrios do Coração/fisiopatologia , Sistema de Condução Cardíaco/patologia , Sistema de Condução Cardíaco/fisiopatologia , Ventrículos do Coração/fisiopatologia , Processamento de Imagem Assistida por Computador , Contração MiocárdicaRESUMO
Indentation tests perpendicular to the major plane of a material have been proposed as a means to index some of its in-plane mechanical properties. We showed the feasibility of such tests in myocardial tissue and established its theoretical basis with a formulation of small indentation superimposed on a finitely stretched half-space of isotropic materials. The purpose of this study is to better understand the mechanics of indentation with respect to the relative effects of indenter size, indentation depth, and specimen size, as well as the effects of material properties. Accordingly, we performed indentation tests on slabs of silicone rubber fabricated with both isotropic, as well as transversely isotropic, material symmetry. We performed indentation tests in different thickness specimens with varying sizes of indenters, amounts of indentation, and amounts of in-plane stretch. We used finite-element method simulations to supplement the experimental data. The combined experimental and modeling data provide the following useful guidelines for future indentation tests in finite-size specimens: (i) to avoid artifacts from boundary effects, the in-plane specimen dimensions should be at least 15 times the indenter size; (ii) to avoid nonlinearities associated with finite-thickness effects, the thickness-to-radius ratio should be >10 and thickness to indentation depth ratio should be >5; and (iii) we also showed that combined indentation and in-plane stretch could distinguish the stiffer direction of a transversely isotropic material.
Assuntos
Teste de Materiais , Modelos Cardiovasculares , Elastômeros de Silicone , Anisotropia , Simulação por Computador , Elasticidade , Estresse MecânicoAssuntos
Reanimação Cardiopulmonar , Animais , Velocidade do Fluxo Sanguíneo , Circulação Coronária , Coleta de Dados/normas , Modelos Animais de Doenças , Cães , Parada Cardíaca/fisiopatologia , Parada Cardíaca/terapia , Laboratórios , Padrões de Referência , Projetos de Pesquisa/normas , Roedores , SuínosAssuntos
Reanimação Cardiopulmonar , Animais , Velocidade do Fluxo Sanguíneo , Circulação Coronária , Coleta de Dados/normas , Modelos Animais de Doenças , Cães , Parada Cardíaca/fisiopatologia , Parada Cardíaca/terapia , Laboratórios , Padrões de Referência , Projetos de Pesquisa/normas , Roedores , SuínosAssuntos
Reanimação Cardiopulmonar , Animais , Velocidade do Fluxo Sanguíneo , Circulação Coronária , Coleta de Dados/normas , Modelos Animais de Doenças , Cães , Parada Cardíaca/fisiopatologia , Parada Cardíaca/terapia , Laboratórios , Padrões de Referência , Projetos de Pesquisa/normas , Roedores , SuínosRESUMO
Primary muscle abnormalities and/or alterations in regional loading may be critical in myocardial infarct expansion and remodeling, cardiomyopathy progression, and arrhythmia generation. To differentiate muscle abnormalities from loading abnormalities, an estimation of regional wall stress is needed. Researchers have previously relied on geometric models and finite element analysis to estimate wall stress, but these estimations have not been validated. It has been shown that the transverse stiffness (the ratio of indentation stress to indentation strain during transverse indentations) of a cardiac muscle can be used to estimate the myocardial wall stress. The authors designed and tested a hand-held dynamic indentation system that can determine the regional transverse stiffness of an intact heart in as little as 15 milliseconds, allowing multiple estimations of wall stress over a single contraction cycle. The sensor was validated with a finite-element analysis of the indentation process, as well as with direct measurements on isolated heart muscle, and on soft, nonbiologic materials. The validations confirmed that the dynamic indentation system does accurately estimate myocardial wall stress. This regional-wall-stress sensor could help to enhance the understanding of cardiac pathophysiology, guide therapy, and assist surgeons in planning cardiac surgeries.
Assuntos
Procedimentos Cirúrgicos Cardíacos/instrumentação , Coração/fisiologia , Elasticidade , Desenho de Equipamento , Humanos , Modelos Cardiovasculares , Infarto do Miocárdio/fisiopatologia , Estresse Mecânico , TransdutoresRESUMO
OBJECTIVE: To determine if left ventricular torsion, as measured by magnetic resonance tissue tagging, is afterload dependent in a canine isolated heart model in which neurohumoral responses are absent, and preload is constant. METHODS: In ten isolated, blood perfused, ejecting, canine hearts, three afterloads were studied, while keeping preload constant: low afterload, high afterload (stroke volume reduced by approx. 50% of low afterload), and isovolumic loading (infinite afterload). RESULTS: There were significant effects of afterload on both torsion (P < 0.05) and circumferential shortening (P < 0.0005). Between low and high afterloads, at the anterior region of the endocardium only, where torsion was maximal, there was a significant reduction in torsion (15.1 +/- 2.2 degrees to 7.8 +/- 1.8 degrees, P < 0.05). Between high afterload and isovolumic loading there was no significant change in torsion (7.8 +/- 1.8 degrees to 6.2 +/- 1.5 degrees, P = NS). Circumferential shortening at the anterior endocardium was significantly reduced both between low and high afterload (-0.19 +/- 0.02 to -0.11 +/- 0.02, P < 0.0005), and also between high afterload and isovolumic loading (-0.11 +/- 0.02 to 0.00 +/- 0.02, P < 0.05). Plots of strains with respect to end-systolic volume demonstrated a reduction in both torsion and shortening with afterload-induced increases in end-systolic volume. Torsion, but not circumferential shortening, persisted at isovolumic loading. CONCLUSIONS: Maximal regional torsion of the left ventricle is afterload dependent. The afterload response of torsion appears related to the effects of afterload on end-systolic volume.