A dataset for predicting cloud cover over Europe.

Clouds are important factors when projecting future climate. Unfortunately, future cloud fractional cover (the portion of the sky covered by clouds) is associated with significant uncertainty, making climate projections difficult. In this paper, we present the European Cloud Cover dataset, which can be used to learn statistical relations between cloud cover and other environmental variables, to potentially improve future climate projections. The dataset was created using a novel technique called Area Weighting Regridding Scheme to map satellite observations to cloud fractional cover on the same grid as the other variables in the dataset. Baseline experiments using autoregressive models document that it is possible to use the dataset to predict cloud fractional cover.

A Deep Diagnostic Framework Using Explainable Artificial Intelligence and Clustering.

An important part of diagnostics is to gain insight into properties that characterize a disease. Machine learning has been used for this purpose, for instance, to identify biomarkers in genomics. However, when patient data are presented as images, identifying properties that characterize a disease becomes far more challenging. A common strategy involves extracting features from the images and analyzing their occurrence in healthy versus pathological images. A limitation of this approach is that the ability to gain new insights into the disease from the data is constrained by the information in the extracted features. Typically, these features are manually extracted by humans, which further limits the potential for new insights. To overcome these limitations, in this paper, we propose a novel framework that provides insights into diseases without relying on handcrafted features or human intervention. Our framework is based on deep learning (DL), explainable artificial intelligence (XAI), and clustering. DL is employed to learn deep patterns, enabling efficient differentiation between healthy and pathological images. Explainable artificial intelligence (XAI) visualizes these patterns, and a novel "explanation-weighted" clustering technique is introduced to gain an overview of these patterns across multiple patients. We applied the method to images from the gastrointestinal tract. In addition to real healthy images and real images of polyps, some of the images had synthetic shapes added to represent other types of pathologies than polyps. The results show that our proposed method was capable of organizing the images based on the reasons they were diagnosed as pathological, achieving high cluster quality and a rand index close to or equal to one.

VISEM-Tracking, a human spermatozoa tracking dataset.

A manual assessment of sperm motility requires microscopy observation, which is challenging due to the fast-moving spermatozoa in the field of view. To obtain correct results, manual evaluation requires extensive training. Therefore, computer-aided sperm analysis (CASA) has become increasingly used in clinics. Despite this, more data is needed to train supervised machine learning approaches in order to improve accuracy and reliability in the assessment of sperm motility and kinematics. In this regard, we provide a dataset called VISEM-Tracking with 20 video recordings of 30 seconds (comprising 29,196 frames) of wet semen preparations with manually annotated bounding-box coordinates and a set of sperm characteristics analyzed by experts in the domain. In addition to the annotated data, we provide unlabeled video clips for easy-to-use access and analysis of the data via methods such as self- or unsupervised learning. As part of this paper, we present baseline sperm detection performances using the YOLOv5 deep learning (DL) model trained on the VISEM-Tracking dataset. As a result, we show that the dataset can be used to train complex DL models to analyze spermatozoa.

Introducing Region Based Pooling for handling a varied number of EEG channels for deep learning models.

Introduction: A challenge when applying an artificial intelligence (AI) deep learning (DL) approach to novel electroencephalography (EEG) data, is the DL architecture's lack of adaptability to changing numbers of EEG channels. That is, the number of channels cannot vary neither in the training data, nor upon deployment. Such highly specific hardware constraints put major limitations on the clinical usability and scalability of the DL models. Methods: In this work, we propose a technique for handling such varied numbers of EEG channels by splitting the EEG montages into distinct regions and merge the channels within the same region to a region representation. The solution is termed Region Based Pooling (RBP). The procedure of splitting the montage into regions is performed repeatedly with different region configurations, to minimize potential loss of information. As RBP maps a varied number of EEG channels to a fixed number of region representations, both current and future DL architectures may apply RBP with ease. To demonstrate and evaluate the adequacy of RBP to handle a varied number of EEG channels, sex classification based solely on EEG was used as a test example. The DL models were trained on 129 channels, and tested on 32, 65, and 129-channels versions of the data using the same channel positions scheme. The baselines for comparison were zero-filling the missing channels and applying spherical spline interpolation. The performances were estimated using 5-fold cross validation. Results: For the 32-channel system version, the mean AUC values across the folds were: RBP (93.34%), spherical spline interpolation (93.36%), and zero-filling (76.82%). Similarly, on the 65-channel system version, the performances were: RBP (93.66%), spherical spline interpolation (93.50%), and zero-filling (85.58%). Finally, the 129-channel system version produced the following results: RBP (94.68%), spherical spline interpolation (93.86%), and zero-filling (91.92%). Conclusion: In conclusion, RBP obtained similar results to spherical spline interpolation, and superior results to zero-filling. We encourage further research and development of DL models in the cross-dataset setting, including the use of methods such as RBP and spherical spline interpolation to handle a varied number of EEG channels.

SinGAN-Seg: Synthetic training data generation for medical image segmentation.

Analyzing medical data to find abnormalities is a time-consuming and costly task, particularly for rare abnormalities, requiring tremendous efforts from medical experts. Therefore, artificial intelligence has become a popular tool for the automatic processing of medical data, acting as a supportive tool for doctors. However, the machine learning models used to build these tools are highly dependent on the data used to train them. Large amounts of data can be difficult to obtain in medicine due to privacy reasons, expensive and time-consuming annotations, and a general lack of data samples for infrequent lesions. In this study, we present a novel synthetic data generation pipeline, called SinGAN-Seg, to produce synthetic medical images with corresponding masks using a single training image. Our method is different from the traditional generative adversarial networks (GANs) because our model needs only a single image and the corresponding ground truth to train. We also show that the synthetic data generation pipeline can be used to produce alternative artificial segmentation datasets with corresponding ground truth masks when real datasets are not allowed to share. The pipeline is evaluated using qualitative and quantitative comparisons between real data and synthetic data to show that the style transfer technique used in our pipeline significantly improves the quality of the generated data and our method is better than other state-of-the-art GANs to prepare synthetic images when the size of training datasets are limited. By training UNet++ using both real data and the synthetic data generated from the SinGAN-Seg pipeline, we show that the models trained on synthetic data have very close performances to those trained on real data when both datasets have a considerable amount of training data. In contrast, we show that synthetic data generated from the SinGAN-Seg pipeline improves the performance of segmentation models when training datasets do not have a considerable amount of data. All experiments were performed using an open dataset and the code is publicly available on GitHub.

Deep Tower Networks for Efficient Temperature Forecasting from Multiple Data Sources.

Many data related problems involve handling multiple data streams of different types at the same time. These problems are both complex and challenging, and researchers often end up using only one modality or combining them via a late fusion based approach. To tackle this challenge, we develop and investigate the usefulness of a novel deep learning method called tower networks. This method is able to learn from multiple input data sources at once. We apply the tower network to the problem of short-term temperature forecasting. First, we compare our method to a number of meteorological baselines and simple statistical approaches. Further, we compare the tower network with two core network architectures that are often used, namely the convolutional neural network (CNN) and convolutional long short-term memory (convLSTM). The methods are compared for the task of weather forecasting performance, and the deep learning methods are also compared in terms of memory usage and training time. The tower network performs well in comparison both with the meteorological baselines, and with the other core architectures. Compared with the state-of-the-art operational Norwegian weather forecasting service, yr.no, the tower network has an overall 11% smaller root mean squared forecasting error. For the core architectures, the tower network documents competitive performance and proofs to be more robust compared to CNN and convLSTM models.

Artificial intelligence in dry eye disease.

Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. Many tests used in the diagnosis of DED rely on an experienced observer for image interpretation, which may be considered subjective and result in variation in diagnosis. Since artificial intelligence (AI) systems are capable of advanced problem solving, use of such techniques could lead to more objective diagnosis. Although the term 'AI' is commonly used, recent success in its applications to medicine is mainly due to advancements in the sub-field of machine learning, which has been used to automatically classify images and predict medical outcomes. Powerful machine learning techniques have been harnessed to understand nuances in patient data and medical images, aiming for consistent diagnosis and stratification of disease severity. This is the first literature review on the use of AI in DED. We provide a brief introduction to AI, report its current use in DED research and its potential for application in the clinic. Our review found that AI has been employed in a wide range of DED clinical tests and research applications, primarily for interpretation of interferometry, slit-lamp and meibography images. While initial results are promising, much work is still needed on model development, clinical testing and standardisation.

DeepFake electrocardiograms using generative adversarial networks are the beginning of the end for privacy issues in medicine.

Recent global developments underscore the prominent role big data have in modern medical science. But privacy issues constitute a prevalent problem for collecting and sharing data between researchers. However, synthetic data generated to represent real data carrying similar information and distribution may alleviate the privacy issue. In this study, we present generative adversarial networks (GANs) capable of generating realistic synthetic DeepFake 10-s 12-lead electrocardiograms (ECGs). We have developed and compared two methods, named WaveGAN* and Pulse2Pulse. We trained the GANs with 7,233 real normal ECGs to produce 121,977 DeepFake normal ECGs. By verifying the ECGs using a commercial ECG interpretation program (MUSE 12SL, GE Healthcare), we demonstrate that the Pulse2Pulse GAN was superior to the WaveGAN* to produce realistic ECGs. ECG intervals and amplitudes were similar between the DeepFake and real ECGs. Although these synthetic ECGs mimic the dataset used for creation, the ECGs are not linked to any individuals and may thus be used freely. The synthetic dataset will be available as open access for researchers at OSF.io and the DeepFake generator available at the Python Package Index (PyPI) for generating synthetic ECGs. In conclusion, we were able to generate realistic synthetic ECGs using generative adversarial neural networks on normal ECGs from two population studies, thereby addressing the relevant privacy issues in medical datasets.

Kvasir-Capsule, a video capsule endoscopy dataset.

Artificial intelligence (AI) is predicted to have profound effects on the future of video capsule endoscopy (VCE) technology. The potential lies in improving anomaly detection while reducing manual labour. Existing work demonstrates the promising benefits of AI-based computer-assisted diagnosis systems for VCE. They also show great potential for improvements to achieve even better results. Also, medical data is often sparse and unavailable to the research community, and qualified medical personnel rarely have time for the tedious labelling work. We present Kvasir-Capsule, a large VCE dataset collected from examinations at a Norwegian Hospital. Kvasir-Capsule consists of 117 videos which can be used to extract a total of 4,741,504 image frames. We have labelled and medically verified 47,238 frames with a bounding box around findings from 14 different classes. In addition to these labelled images, there are 4,694,266 unlabelled frames included in the dataset. The Kvasir-Capsule dataset can play a valuable role in developing better algorithms in order to reach true potential of VCE technology.

Game-Theoretic Learning for Sensor Reliability Evaluation Without Knowledge of the Ground Truth.

Sensor fusion has attracted a lot of research attention during the few last years. Recently, a new research direction has emerged dealing with sensor fusion without knowledge of the ground truth. In this article, we present a novel solution to the latter pertinent problem. In contrast to the first reported solutions to this problem, we present a solution that does not involve any assumption on the group average reliability which makes our results more general than previous works. We devise a strategic game where we show that a perfect partitioning of the sensors into reliable and unreliable groups corresponds to a Nash equilibrium of the game. Furthermore, we give sound theoretical results that prove that those equilibria are indeed the unique Nash equilibria of the game. We then propose a solution involving a team of learning automata (LA) to unveil the identity of each sensor, whether it is reliable or unreliable, using game-theoretic learning. The experimental results show the accuracy of our solution and its ability to deal with settings that are unsolvable by legacy works.

Enhanced Equivalence Projective Simulation: A Framework for Modeling Formation of Stimulus Equivalence Classes.

Formation of stimulus equivalence classes has been recently modeled through equivalence projective simulation (EPS), a modified version of a projective simulation (PS) learning agent. PS is endowed with an episodic memory that resembles the internal representation in the brain and the concept of cognitive maps. PS flexibility and interpretability enable the EPS model and, consequently the model we explore in this letter, to simulate a broad range of behaviors in matching-to-sample experiments. The episodic memory, the basis for agent decision making, is formed during the training phase. Derived relations in the EPS model that are not trained directly but can be established via the network's connections are computed on demand during the test phase trials by likelihood reasoning. In this letter, we investigate the formation of derived relations in the EPS model using network enhancement (NE), an iterative diffusion process, that yields an offline approach to the agent decision making at the testing phase. The NE process is applied after the training phase to denoise the memory network so that derived relations are formed in the memory network and retrieved during the testing phase. During the NE phase, indirect relations are enhanced, and the structure of episodic memory changes. This approach can also be interpreted as the agent's replay after the training phase, which is in line with recent findings in behavioral and neuroscience studies. In comparison with EPS, our model is able to model the formation of derived relations and other features such as the nodal effect in a more intrinsic manner. Decision making in the test phase is not an ad hoc computational method, but rather a retrieval and update process of the cached relations from the memory network based on the test trial. In order to study the role of parameters on agent performance, the proposed model is simulated and the results discussed through various experimental settings.

Achieving Fair Load Balancing by Invoking a Learning Automata-Based Two-Time-Scale Separation Paradigm.

In this article, we consider the problem of load balancing (LB), but, unlike the approaches that have been proposed earlier, we attempt to resolve the problem in a fair manner (or rather, it would probably be more appropriate to describe it as an ϵ -fair manner because, although the LB can, probably, never be totally fair, we achieve this by being "as close to fair as possible"). The solution that we propose invokes a novel stochastic learning automaton (LA) scheme, so as to attain a distribution of the load to a number of nodes, where the performance level at the different nodes is approximately equal and each user experiences approximately the same Quality of the Service (QoS) irrespective of which node that he/she is connected to. Since the load is dynamically varying, static resource allocation schemes are doomed to underperform. This is further relevant in cloud environments, where we need dynamic approaches because the available resources are unpredictable (or rather, uncertain) by virtue of the shared nature of the resource pool. Furthermore, we prove here that there is a coupling involving LA's probabilities and the dynamics of the rewards themselves, which renders the environments to be nonstationary. This leads to the emergence of the so-called property of "stochastic diminishing rewards." Our newly proposed novel LA algorithm ϵ -optimally solves the problem, and this is done by resorting to a two-time-scale-based stochastic learning paradigm. As far as we know, the results presented here are of a pioneering sort, and we are unaware of any comparable results.

HyperKvasir, a comprehensive multi-class image and video dataset for gastrointestinal endoscopy.

Artificial intelligence is currently a hot topic in medicine. However, medical data is often sparse and hard to obtain due to legal restrictions and lack of medical personnel for the cumbersome and tedious process to manually label training data. These constraints make it difficult to develop systems for automatic analysis, like detecting disease or other lesions. In this respect, this article presents HyperKvasir, the largest image and video dataset of the gastrointestinal tract available today. The data is collected during real gastro- and colonoscopy examinations at Bærum Hospital in Norway and partly labeled by experienced gastrointestinal endoscopists. The dataset contains 110,079 images and 374 videos, and represents anatomical landmarks as well as pathological and normal findings. The total number of images and video frames together is around 1 million. Initial experiments demonstrate the potential benefits of artificial intelligence-based computer-assisted diagnosis systems. The HyperKvasir dataset can play a valuable role in developing better algorithms and computer-assisted examination systems not only for gastro- and colonoscopy, but also for other fields in medicine.

Equivalence Projective Simulation as a Framework for Modeling Formation of Stimulus Equivalence Classes.

Stimulus equivalence (SE) and projective simulation (PS) study complex behavior, the former in human subjects and the latter in artificial agents. We apply the PS learning framework for modeling the formation of equivalence classes. For this purpose, we first modify the PS model to accommodate imitating the emergence of equivalence relations. Later, we formulate the SE formation through the matching-to-sample (MTS) procedure. The proposed version of PS model, called the equivalence projective simulation (EPS) model, is able to act within a varying action set and derive new relations without receiving feedback from the environment. To the best of our knowledge, it is the first time that the field of equivalence theory in behavior analysis has been linked to an artificial agent in a machine learning context. This model has many advantages over existing neural network models. Briefly, our EPS model is not a black box model, but rather a model with the capability of easy interpretation and flexibility for further modifications. To validate the model, some experimental results performed by prominent behavior analysts are simulated. The results confirm that the EPS model is able to reliably simulate and replicate the same behavior as real experiments in various settings, including formation of equivalence relations in typical participants, nonformation of equivalence relations in language-disabled children, and nodal effect in a linear series with nodal distance five. Moreover, through a hypothetical experiment, we discuss the possibility of applying EPS in further equivalence theory research.

Machine Learning-Based Analysis of Sperm Videos and Participant Data for Male Fertility Prediction.

Methods for automatic analysis of clinical data are usually targeted towards a specific modality and do not make use of all relevant data available. In the field of male human reproduction, clinical and biological data are not used to its fullest potential. Manual evaluation of a semen sample using a microscope is time-consuming and requires extensive training. Furthermore, the validity of manual semen analysis has been questioned due to limited reproducibility, and often high inter-personnel variation. The existing computer-aided sperm analyzer systems are not recommended for routine clinical use due to methodological challenges caused by the consistency of the semen sample. Thus, there is a need for an improved methodology. We use modern and classical machine learning techniques together with a dataset consisting of 85 videos of human semen samples and related participant data to automatically predict sperm motility. Used techniques include simple linear regression and more sophisticated methods using convolutional neural networks. Our results indicate that sperm motility prediction based on deep learning using sperm motility videos is rapid to perform and consistent. Adding participant data did not improve the algorithms performance. In conclusion, machine learning-based automatic analysis may become a valuable tool in male infertility investigation and research.

Utilization of Norway's emergency wards: the second 5 years after the introduction of the patient list system.

Utilization of services is an important indicator for estimating access to healthcare. In Norway, the General Practitioner Scheme, a patient list system, was established in 2001 to enable a stable doctor-patient relationship. Although satisfaction with the system is generally high, people often choose a more accessible but inferior solution for routine care: emergency wards. The aim of the article is to investigate contact patterns in primary health care situations for the total population in urban and remote areas of Norway and for major immigrant groups in Oslo. The primary regression model had a cross-sectional study design analyzing 2,609,107 consultations in representative municipalities across Norway, estimating the probability of choosing the emergency ward in substitution to a general practitioner. In a second regression model comprising 625,590 consultations in Oslo, we calculated this likelihood for immigrants from the 14 largest groups. We noted substantial differences in emergency ward utilization between ethnic Norwegians both in rural and remote areas and among the various immigrant groups residing in Oslo. Oslo utilization of emergency ward services for the whole population declined, and so did this use among all immigrant groups after 2009. Other municipalities, while overwhelmingly ethnically Norwegian, showed diverse patterns including an increase in some and a decrease in others, results which we were unable to explain.