RESUMO
PURPOSE: To compare electroretinogram (ERG) responses measured with a skin electrode with those from a corneal-contact electrode in healthy adults. METHOD: Sixty two eyes of 31 healthy adults (8 men and 23 women) were enrolled (mean age 34.0 +/- 8.1 years). ERG responses for full-field and single flash stimuli was recorded with skin electrodes and corneal-contact electrodes. Morphology of the ERG waveform, a-wave and b-wave amplitudes, b/a ratios, and a-wave and b-wave implicit times were compared between the two electrode measurements. Correlations between the two measurements were also examined. RESULTS: All features of the ERG waveform were identifiable using the skin electrodes. In the skin electrode ERGs, a-wave and b-wave amplitudes, and the b/a ratios were smaller (p<0.001) and the a-wave and b-wave implicit times were shorter (p<0.001) than those in the corneal-contact electrode ERGs. The B-wave amplitudes, b/a ratios and the a-wave and b-wave implicit times showed significant correlations between the two electrodes (p<0.01). In 16 eyes the OP4 was detected as the b-wave. CONCLUSION: The skin electrode ERG had shorter amplitudes and shorter implicit times than the corneal electrode ERGs, but corresponded well in its morphology to the corneal-contact electrode ERGs. Skin electrodes ERG would be useful for the examination of child patients and patients with corneal diseases. Further study is required for clinical application.
Assuntos
Lentes de Contato , Córnea/fisiologia , Eletrorretinografia/métodos , Fenômenos Fisiológicos da Pele , Adulto , Eletrodos , Eletrorretinografia/instrumentação , Feminino , Humanos , Masculino , Estimulação Luminosa/métodosRESUMO
BACKGROUND: We report a case of melanoma-associated retinopathy (MAR) associated with positive auto-antibodies against retinal bipolar cells, which has been rarely reported in Japan. CASE REPORT: A 33 year-old woman noticed shimmering vision, photopsias, blurred vision, and night blindness OS in April 2009, and visited Kagoshima Miyata Eye Clinic in May 2009. She had been continuously treated for malignant melanoma on her left finger since 2007. At her initial visit, the corrected visual acuity was 1.5 OD and 1.2 OS, and slit-lamp examination revealed clear ocular media OU. Funduscopic examination showed normal appearance of the retina OU, except for a mild narrowing of the retinal arteries OS. Humphrey field analyzer revealed a reduction of retinal sensitivity within the central 30 degrees OS. The maximum left eye response of electroretinogram (ERG) showed a negative waveform. The immuno-cytochemical test revealed antibodies against retinal bipolar cells, which confirmed the diagnosis of MAR. CONCLUSION: Characteristic subjective symptoms, Humphrey field analyzer and ERG are useful for the diagnosis of MAR.