Development and Validation of the Norfolk Quality of Life Fatigue Tool (QOL-F): A New Measure of Perception of Fatigue.

OBJECTIVES: To design a questionnaire to evaluate and distinguish between cognitive and physical aspects of fatigue in different age groups of "nondiseased" people and guide appropriate prevention and interventions for the impact of frailty occurring in normative aging. STUDY DESIGN AND PARTICIPANTS: The Norfolk QOL-Fatigue (QOL-F) with items of cognitive and physical fatigue, anxiety, and depression from validated questionnaires including items from the Patient-Reported Outcomes Measure Information System (PROMIS) databank was developed. The preliminary QOL-F was administered to 409 healthy multiethnic local participants (30-80 years old) in 5 age groups. METHODS: The authors distilled the item pool using exploratory (EFA) and confirmatory factor analysis (CFA). EFA identified 5 latent groups as possible factors related to problems due to fatigue, subjective fatigue, reduced activities, impaired activities of daily living (ADL), and depression. RESULTS: CFA demonstrated good overall fit [χ2(172) = 1094.23, P < .001; Tucker-Lewis index = 0.978; root mean square error of approximation = 0.049] with factor loadings >0.617 and strong interfactor correlations (0.69-0.83), suggesting that fatigue in each domain is closely related to other domains and to the overall scale except for ADL. The 5-factor solution displayed good internal consistency (Cronbach α = 0.78-0.94). Total and domain scores were fairly equivalent in all age groups except for the 40 to 49-year-old group with better overall scores. In addition, 70 to 79-year-olds had better ADL scores. In item response analysis, factor scores in different age groups were similar, so age may not be a significant driver of fatigue scores. Fatigue scores were significantly higher in females than in males (P < .05). CONCLUSIONS AND CLINICAL IMPLICATIONS: The developed Norfolk QOL-F tool demonstrated fatigue as a perceived cognitive phenomenon rather than an objective physical measure, suggesting mandatory inclusion of cognitive as well as physical measures in the evaluation of people as they age. QOL-F is able to distinguish QOL-F domain scores unique to different age groups, proposing clinical benefits from physical, balance, and cognitive interventions tailored to impact frailty occurring in normative aging.

An Introduction to the Minnesota Multiphasic Personality Inventory-Adolescent-Restructured Form (MMPI-A-RF).

The Minnesota Multiphasic Personality Inventory-Adolescent-Restructured Form (MMPI-A-RF; Archer, Handel, Ben-Porath, & Tellegen, 2016) is a new broadband measure of adolescent psychopathology and personality. The MMPI-A-RF is the adolescent counterpart of the MMPI-2-RF (Ben-Porath & Tellegen, 2008/2011). The goal of the MMPI-2-RF development project was to capture the clinically significant substance of the MMPI-2 item pool with a psychometrically sound measure linked to contemporary models of personality and psychopathology (Ben-Porath & Tellegen, 2008/2011). Using the MMPI-2-RF scales and development methods as models, Archer et al. (2016) developed a 241-item adolescent self-report inventory-in contrast to the 478-items of the MMPI-A-that includes 48 new and revised scales. In this manuscript, I provide an overview of the rationale for the development of the MMPI-A-RF, an abbreviated review of its development process, brief descriptions of its 48 scales, and a subset of analyses bearing on reliability and validity. As with the MMPI-2-RF, one of our primary goals was to develop scales with improved discriminant validity relative to the heterogeneous Clinical Scales of the MMPI-2 and MMPI-A. The MMPI-A-RF development process employed a large sample of 15,128 adolescents (9,286 boys and 5,842 girls) drawn from a variety of settings. In addition to the development sample, subsequent validation analyses were conducted in multiple independent samples including numerous external criterion measures. The MMPI-A-RF is designed to provide a comprehensive assessment of adolescent psychopathology and personality in a wide array of clinical and forensic settings.

Psychometric Examination, Adaptation, and Evaluation of the Hebrew Translation of the MMPI-2-RF VRIN-r and TRIN-r Validity Scales.

In this study we examined the utility of the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008/2011; Tellegen & Ben-Porath, 2008/2011) Variable Response Inconsistency-Revised (VRIN-r) and True Response Inconsistency-Revised (TRIN-r) scales, including alternative versions of the scales, in the Hebrew translation of the test. First, we examined the applicability of the U.S. VRIN-r and TRIN-r scales in an Israeli Hebrew-speaking mixed clinical sample, and replaced original item pairs that did not meet the development criteria with substitution item pairs that did. Then, using the Israeli normative sample and a pure clinical sample, we compared the psychometric functioning of the adapted Hebrew-language VRIN-r and TRIN-r scales with that of the original versions of these scales under various conditions of simulated non-content-based (random and fixed) responding. Overall, results showed that the adapted versions of the scales did not improve on the original ones. We therefore recommend using the U.S. VRIN-r and TRIN-r versions, which could also facilitate cross-cultural comparisons.

Walking-Induced Fatigue Leads to Increased Falls Risk in Older Adults.

BACKGROUND: For older adults, falls are a serious health problem, with more than 30% of people older than 65 suffering a fall at least once a year. One element often overlooked in the assessment of falls is whether a person's balance, walking ability, and overall falls risk is affected by performing activities of daily living such as walking. OBJECTIVE: This study assessed the immediate impact of incline walking at a moderate pace on falls risk, leg strength, reaction time, gait, and balance in 75 healthy adults from 30 to 79 years of age. Subjects were subdivided into 5 equal groups based on their age (group 1, 30-39 years; group 2, 40-49 years; group 3, 50-59 years; group 4, 60-69 years; group 5, 70-79 years). METHODS: Each person's falls risk (using the Physiological Profile Assessment), simple reaction time, leg strength, walking ability, and standing balance were assessed before and after a period of incline walking on an automated treadmill. The walking task consisted of three 5-minute trials at a faster than preferred pace. Fatigue during walking was elicited by increasing the treadmill incline in increments of 2° (from level) every minute to a maximum of 8°. RESULTS: As predicted, significant age-related differences were observed before the walking activity. In general, increasing age was associated with declines in gait speed, lower limb strength, slower reaction times, and increases in overall falls risk. Following the treadmill task, older adults exhibited increased sway (path length 60-69 years; 10.2 ± 0.7 to 12.1 ± 0.7 cm: 70-79 years; 12.8 ± 1.1 to 15.1 ± 0.8 cm), slower reaction times (70-79 years; 256 ± 6 to 287 ± 8 ms), and declines in lower limb strength (60-69 years; 36 ± 2 to 31 ± 1 kg: 70-79 years; 32.3 ± 2 to 27 ± 1 kg). However, a significant increase in overall falls risk (pre; 0.51 ± 0.17: post; 1.01 ± 0.18) was only seen in the oldest group (70-79 years). For all other persons (30-69 years), changes resulting from the treadmill-walking task did not lead to a significant increase in falls risk. CONCLUSIONS: As most falls occur when an individual is moving and/or fatigued, assessing functional properties related to balance, gait, strength, and falls risk in older adults both at rest and following activity may provide additional insight.

"False feigners": Examining the impact of non-content-based invalid responding on the Minnesota Multiphasic Personality Inventory-2 Restructured Form content-based invalid responding indicators.

Misinterpretation of non-content-based invalid (e.g., random, fixed) responding as overreporting or underreporting is likely to adversely impact test interpretation and could bias inferences about examinee intentions. We examined the impact of non-content-based invalid responding on the following Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF) content-based invalid responding indicators: Infrequent Responses (F-r), Infrequent Psychopathology Responses (FP-r), Infrequent Somatic Responses (FS), Symptom Validity (FBS-r), Response Bias Scale (RBS), Uncommon Virtues (L-r), and Adjustment Validity (K-r). In 4 samples from which invalid responders were excluded, we systematically inserted increasing percentages of random, acquiescent, or counter-acquiescent item responses ranging from 0% to 100% and examined the impact that non-content-based invalid response styles had on the content-based invalid responding indicators. F-r, FP-r, FS, RBS, and L-r were susceptible to non-content-based invalid responding, whereas FBS-r and K-r were unaffected. Individuals with Variable Response Inconsistency (VRIN-r) and True Response Inconsistency (TRIN-r) elevations were removed, and the frequencies of content-based invalid responding elevations were then reexamined for false indications of feigning. Findings were consistent across samples and emphasize the need to screen for non-content-based invalid responding before screening for content-based invalid responding in the assessment of personality and psychopathology. VRIN-r and TRIN-r were useful in detecting most-but not all-cases of non-content-based invalid responding. A small but meaningful percentage of the remaining individuals were misclassified as overreporters (i.e., false feigners) by FP-r and FS. Clinicians should interpret FP-r and FS with some caution in the presence of moderate levels of non-content-based invalid responding. Post hoc examinations of scale characteristics indicated that the most susceptible scales were brief, consisted of rarely endorsed items, included a relatively high percentage of true-keyed items, and required a low percentage of endorsed items to reach clinical significance. (PsycINFO Database Record

Examining the impact of unscorable item responses on the validity and interpretability of MMPI-2/MMPI-2-RF Restructured Clinical (RC) Scale scores.

This article examined the impact of unscorable item responses on the psychometric validity and practical interpretability of scores on the Restructured Clinical (RC) Scales of the Minnesota Multiphasic Personality Inventory-2/Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2/MMPI-2-RF). In analyses conducted with five archival samples, we found that relatively large proportions of unscorable responses (defined as 10% or more of the items scored on a scale) were relatively uncommon, occurring most often in forensic samples. Simulated unscorable responses were inserted in varying proportions (10% to 90%) in place of the responses of participants in two of the archival samples for which criterion data were available. Analyses were conducted to gauge the impact of unscorable responses on the criterion validity of scores on these scales and their interpretability. Impact on validity was evaluated by examining correlations with extra-test variables as a function of increasing levels of unscorable responding. Interpretability was evaluated by examining the proportion of participants who produced clinically elevated RC Scale scores as a function of unscorable responding. Results indicate that whereas scale score validity was relatively robust up to a level of 50% unscorable responses, interpretability was substantially compromised at only 10% unscorable responding. This suggests that prorated scores may be used to correct for the impact of unscorable responses on the interpretability of RC Scale scores at levels as high as 50% unscorable responses. Classification analyses supported this possibility. Further steps needed to explore the feasibility of using prorated scores are discussed.

MMPI-2-RF characteristics of custody evaluation litigants.

The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) is a 338-item objective self-report measure drawn from the 567 items of the MMPI-2. Although there is a substantial MMPI-2 literature regarding child custody litigants, there has been only one previously published study using MMPI-2-RF data in this population that focused on Validity scales L-r and K-r. The current study evaluated the MMPI-2-RF results of 344 child custody litigants and showed substantial consistency between T-score elevations typically found on MMPI-2 Validity scales L and K, and comparable elevations for MMPI-2-RF validity scales L-r and K-r. Mean T-scores well within normal limits characterized results for clinical scales on both instruments. The RC scale intercorrelation patterns, and alpha coefficient values found for MMPI-2-RF scales in a custody population, were also found to be very similar to those reported for other populations. Directions for future research are presented.

Ice Ih-Water Interfacial Free Energy of Simple Water Models with Full Electrostatic Interactions.

We employ the cleaving approach to calculate directly the ice Ih-water interfacial free energy for the simple models of water, TIP4P, TIP4P-Ew, and TIP5P-E, with full electrostatic interactions evaluated via the Ewald sums. The results are in good agreement with experimental values, but lower than previously obtained for TIP4P-Ew and TIP5P-E by indirect methods. We calculate the interfacial free energies for basal, prism, and {112̅0} interfaces and find that the anisotropy of the TIP5P-E model is different from that of the TIP4P models. The effect of including full electrostatic interactions is determined to be smaller than 10% compared to the water models with damped Coulomb interactions, which indicates that the value of the ice-water interfacial free energy is determined predominantly by the short-range packing interaction between water molecules. We also observe a strong linear correlation between the interfacial free energy and the melting temperature of different water models.

Psychometric properties of the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) Clinical, Content, and Supplementary scales in a forensic sample.

In this study, we evaluated the internal psychometric properties and external correlates of scores on the Clinical, Content, and Supplementary scales in a forensic sample of 496 adolescents (315 boys and 181 girls) who were court-ordered to receive psychological evaluations. We examined Cronbach's alpha coefficients, scale intercorrelation matrices, and frequencies of scale elevations. Further, we found varying degrees of support for the convergent and discriminant validity of scores on the MMPI-A (Butcher et al., 1992 ) Clinical, Content, and Supplementary scales. This study adds to the body of literature establishing the utility of the MMPI-A in forensic evaluations.

Correlates of the MMPI-2-RF in a college setting.

The current study examined empirical correlates of scores on Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; A. Tellegen & Y. S. Ben-Porath, 2008; Y. S. Ben-Porath & A. Tellegen, 2008) scales in a college setting. The MMPI-2-RF and six criterion measures (assessing anger, assertiveness, sex roles, cognitive failures, social avoidance, and social fear) were administered to 846 college students (nmen = 264, nwomen = 582) to examine the convergent and discriminant validity of scores on the MMPI-2-RF Specific Problems and Interest scales. Results demonstrated evidence of generally good convergent score validity for the selected MMPI-2-RF scales, reflected in large effect size correlations with criterion measure scores. Further, MMPI-2-RF scale scores demonstrated adequate discriminant validity, reflected in relatively low comparative median correlations between scores on MMPI-2-RF substantive scale sets and criterion measures. Limitations and future directions are discussed.

Validity of the Massachusetts Youth Screening Instrument-2 (MAYSI-2) scales in juvenile justice settings.

High prevalence rates of psychological problems among juvenile offenders underscore the need for effective mental health screening tools in the juvenile justice system. In this study, we evaluated the validity of the Massachusetts Youth Screening Instrument-2 (MAYSI-2) developed by Grisso and Barnum (2001) to identify mental health needs of adolescents in various juvenile justice settings. The sample was 1,192 adolescents (1,082 boys and 110 girls) admitted into Virginia juvenile correction facilities between the dates of July 2004 and June 2006. Analyses revealed higher MAYSI-2 scale scores for girls than for boys and MAYSI-2 scale intercorrelations were similar to those reported in the MAYSI-2 manuals (Grisso & Barnum, 2003, 2006). We also evaluated the concurrent validity of MAYSI-2 scales by examining scale score correlations with related and unrelated extratest variables. Results showed strong convergent validity for several MAYSI-2 scales.

Psychometric functioning of the MMPI-2-RF VRIN-r and TRIN-r scales with varying degrees of randomness, acquiescence, and counter-acquiescence.

In the present study, the authors evaluated the effects of increasing degrees of simulated non-content-based (random or fixed) responding on scores on the newly developed Variable Response Inconsistency-Revised (VRIN-r) and True Response Inconsistency-Revised (TRIN-r) scales of the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF; Y. S. Ben-Porath & A. Tellegen, 2008) and compared the performance of these new scales with the existing VRIN and TRIN scales of the MMPI-2 (J. N. Butcher et al., 2001). The results support the interpretation of VRIN-r and TRIN-r scores as measures of random and fixed responding, respectively. Furthermore, the authors examined how scores on the Restructured Clinical (RC) scales (A. Tellegen et al., 2003) are affected by increasing levels of non-content-based responding and offer practical interpretive recommendations for test users. Finally, the results of the present study indicate that RC validity coefficients are relatively robust in the face of moderate degrees of non-content-based responding.

A review of the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) and the Millon Adolescent Clinical Inventory (MACI) with an emphasis on juvenile justice samples.

The Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) and Millon Adolescent Clinical Inventory (MACI) are frequently used objective personality self-report measures. Given their widespread use, the purpose of the current study was to examine and compare the literature base for the two instruments. A comprehensive review of the literature was conducted between the years 1992 and 2007 using the PsycINFO Database. Results indicate the publication of 277 articles, books, book chapters, monographs, and dissertation abstracts on the MMPI-A. This was compared with the results of a comparable search for the MACI, which yielded 84 citations. The literature was further explored by determining the content of the topic areas addressed for both instruments. A particular focus was placed on the utility of the instruments with juvenile justice populations; scale means, standard deviations, and effect sizes calculated from this literature were examined. Results indicate that the use of the MMPI-A is supported by a substantial literature and a growing research base is also available for the MACI. Both instruments appear to provide useful results in juvenile justice settings.

Langevin thermostat for rigid body dynamics.

We present a new method for isothermal rigid body simulations using the quaternion representation and Langevin dynamics. It can be combined with the traditional Langevin or gradient (Brownian) dynamics for the translational degrees of freedom to correctly sample the canonical distribution in a simulation of rigid molecules. We propose simple, quasisymplectic second-order numerical integrators and test their performance on the TIP4P model of water. We also investigate the optimal choice of thermostat parameters.

An investigation of the psychometric properties of the MMPI-2 Restructured Clinical (RC) scales with mental health inpatients.

In this study, we compared the internal psychometric properties and external correlates of the MMPI-2 (Butcher et al., 2001; Tellegen et al., 2003) Restructured Clinical (RC) scales and corresponding MMPI-2 non-K-corrected Clinical scales in a sample of 280 men and 264 women admitted to inpatient psychiatric units. We evaluated the internal psychometric properties of the RC and Clinical scales by intercorrelation analyses and alpha coefficients. We investigated external correlates of scores from the RC and Clinical scales using selected chart variables, selected Symptom Checklist 90-Revised (Derogatis, 1983, 1994) items, and clinician ratings on the Brief Psychiatric Rating Scale (Overall & Gorham, 1988). Results showed psychometric support for the RC scales in terms of improved intercorrelation patterns and comparable or greater alpha coefficients. Further, external correlational analyses revealed varying degrees of evidence of improvement in convergent and discriminant validity.

Direct calculation of solid-liquid interfacial free energy for molecular systems: TIP4P ice-water interface.

By extending the cleaving method to molecular systems, we perform direct calculations of the ice Ih-water interfacial free energy for the TIP4P model. The values for the basal, prism, and {112[over]0} faces are 23.3+/-0.8 mJ m{-2}, 23.6+/-1.0 mJ m{-2}, and 24.7+/-0.8 mJ m{-2}, respectively. The closeness of these values implies a minimal role of thermodynamic factors in the anisotropic growth of ice crystals. These results are about 20% lower than the best experimental estimates. However, the Turnbull coefficient is about 50% higher than for real water, indicating a possible limitation of the TIP4P model in describing freezing.

Incremental validity of the Minnesota Multiphasic Personality Inventory-2 and symptom checklist-90-revised with mental health inpatients.

This study evaluated the incremental validity of scores from the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and the Symptom Checklist-90-Revised (SCL-90-R) in a sample of mental health inpatients originally published by Archer, Griffin, and Aiduk (1995). The incremental validity of scores from the SCL-90-R primary symptom dimensions and MMPI-2 Clinical, Content, and Restructured Clinical scales was assessed in a sample of 544 mental health inpatients using conceptually related items from the Brief Psychiatric Rating Scale (BPRS) as criteria. A series of hierarchical multiple regressions indicated that scores from the SCL-90-R primary symptom dimensions exhibited limited incremental validity (Mdn DeltaR(2) = .01, range = 0-.01), whereas scores from MMPI-2 scales contributed additional information in the prediction of ratings on all but one BPRS item (Mdn DeltaR( 2) = .08, range = .04-.12).

The classification accuracy of the Minnesota Multiphasic Personality Inventory-Adolescent: effects of modifying the normative sample.

Numerous studies have reported that the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) produces a high frequency of within-normal-limits basic scale profiles for adolescents with significant clinical pathology (e.g., Archer, 2005). The current study builds on the observation that the MMPI-A normative sample included participants who reported a recent history of referral for counseling or therapy services. The 193 adolescents who reported referral for counseling were removed from the normative sample and uniform T-score values were recalculated for basic clinical scale raw scores. The frequency of within-normal-limits profiles was only marginally reduced by using the revised MMPI-A norms. Furthermore, the overall hit rate, positive predictive power, and sensitivity were only slightly improved by removing normative participants referred for counseling and basing norms on the remaining 1,427 adolescents.

A survey of psychological test use patterns among forensic psychologists.

Clinical psychologists are frequently called on to testify in court regarding mental health issues in civil or criminal cases. One of the legal criteria by which admissibility of testimony is determined includes whether the testimony is based on methods that have gained "general acceptance" in their field. In this study, we sought to evaluate the psychological tests used in forensic assessments by members of the American Psychology-Law Society Division of the American Psychological Association, and by diplomates in the American Board of Forensic Psychology. We present test results from this survey, based on 152 respondents, for forensic evaluations conducted with adults using multiscale inventories, single-scale tests, unstructured personality tests, cognitive and/or intellectual tests, neuropsychological tests, risk assessment and psychopathy instruments, sex offender risk assessment instruments, competency or sanity-related instruments, and instruments used to evaluate malingering. In addition, we provide findings for psychological testing involving child-related forensic issues.

External correlates of the MMPI-2 content component scales in mental health inpatients.

External correlates of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) Content Component Scales were identified using an inpatient sample of 544 adults. The Brief Psychiatric Rating Scale (BPRS) and Symptom Checklist 90-Revised (SCL-90-R) produced correlates of the Content Component Scales, demonstrating external validity with clinician-rated and self-report scales. Relationships between MMPI-2 Content Component Scales and patient hospital chart variables were also examined. Results demonstrated cross-criterion validity in that most MMPI-2 Content Component Scales correlated with appropriate BPRS dimensions, SCL-90-R items, and other patient variables. Discriminant validity of the Content Component Scales was also demonstrated. In addition, the finding that similar patterns of correlates are produced when the component scales are correlated with a self-report measure, as well as clinician ratings and medical chart variables, provides converging lines of evidence supporting the construct validity of the Content Component Scales.