RESUMO
Eosinophilic granuloma EG is a benign self-limiting disease, which belongs to the spectrum of Langerhans' cell histiocytosis LCH. The etiology of LCH remains unknown, although the evidence indicates that it is a clonal proliferative disorder of Langerhans cells, it has also been characterized as reactive disorder, neoplastic process and a berrant immune response. Eosinophilic granuloma is characterized by single or multiple skeletal lesions occurring predominately in children, adolescents and young adults, it accounts for 70% of LCH. It is more common in males, and the common sites are the skull, mandible, ribs, spines and long bones particularly the femur and the humerus. The estimated incidence of EG is 3-4 per million of the population. Vertebral bone involvement is rarely seen and usually affects the vertebral body. We are reporting an unusual case of EG in a female child presented with a solitary lesion at posterior element of lumbar vertebra.
Assuntos
Granuloma Eosinófilo/diagnóstico , Vértebras Lombares/patologia , Doenças da Coluna Vertebral/diagnóstico , Biópsia por Agulha , Transplante Ósseo/métodos , Criança , Terapia Combinada , Curetagem/métodos , Granuloma Eosinófilo/cirurgia , Feminino , Seguimentos , Humanos , Imuno-Histoquímica , Dor Lombar/diagnóstico , Dor Lombar/etiologia , Vértebras Lombares/cirurgia , Medição de Risco , Índice de Gravidade de Doença , Doenças da Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Eosinophilic granuloma EG is a well-recognized benign form of Langerhans cell histiocytosis, most commonly involving the skull bones. In this paper, we report an 8-year-old girl with EG of posterior element of vertebra; she had complete resolution with surgical curettage and bone grafting.
Assuntos
Granuloma Eosinófilo/diagnóstico por imagem , Granuloma Eosinófilo/cirurgia , Doenças da Coluna Vertebral/diagnóstico por imagem , Doenças da Coluna Vertebral/cirurgia , Transplante Ósseo/métodos , Criança , Terapia Combinada , Curetagem/métodos , Granuloma Eosinófilo/patologia , Feminino , Seguimentos , Humanos , Vértebras Lombares/patologia , Medição de Risco , Arábia Saudita , Doenças da Coluna Vertebral/patologia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Portal vein thrombosis is a recognized complication after splenectomy in beta-thalassemia major due to the chronic hypercoagulable state which has been recognized to exist in childhood thalassemia and contribute to thromboembolic events. We are reporting one patient with beta-thalassemia major developed portal vein thrombosis following splenectomy.