Mini-open versus open decompression and fusion for lumbar degenerative spondylolisthesis with stenosis.

The outcome of less invasive surgical techniques in comparison to traditional surgical techniques has been the source of debate. In this retrospective study, 51 patients who had undergone posterior lumbar fusion along with bilateral decompression were enrolled. Twenty-one patients underwent fusion using a standard, midline open technique (open group) and 30 patients underwent fusion using a mini-open technique, with a small, central incision for the decompression and bilateral paramedian incisions for the posterolateral fusion and placement of cannulated pedicle screws (mini-open group). Surgical variables were compared between the 2 groups. Patients in both groups experienced significant improvements in leg pain at 12 months, with a reduction in visual analog scale scores from 7.6 to 2.4 in the open group, and 7.8 to 2.3 in the mini-open group. There were no statistical differences between the groups in the magnitude of improvement of either the visual analog scale or Oswestry Disability Index scores. Operative times, blood loss, and length of hospitalization failed to show statistically significant differences between the groups, although there was a trend toward less blood loss and shorter hospitalization in the mini-open group. Fusion results and complications were similar between the 2 groups. Both techniques resulted in similarly statistically significant improvements in pain and clinical function.

Total synthesis and absolute configuration of (-)-berkeleyamide A.

A chiral-pool approach to (-)-berkeleyamide A 1 based on a diastereoselective nitrile oxide [3 + 2]-cycloaddition completes the first total synthesis establishing the absolute stereochemistry of the natural product.

Percutaneous techniques for minimally invasive posterior lumbar fusion.

Percutaneous pedicle screw fixation for lumbar posterolateral instrumented fusion is an attractive alternative to standard open techniques. The technical aspects of this procedure can be challenging and even frustrating when first learning the technique. However, once these techniques have been mastered, they offer a safe, less invasive, less traumatic, more aesthetic method for performing fusion. The authors have outlined a step-by-step method for performing this surgery, and include a case series that demonstrates excellent results in patients treated with this procedure.

Delayed femoral shaft fracture secondary to nail gun injury: a case report.

Nail gun injuries are common workplace occurrences among construction workers; however, delayed fractures of the femur after a nail gun injury are not found in the medical literature. We report the case of a patient who presented with such a fracture 3 days after accidentally firing a nail into his thigh. The patient was taken to the operating room for intramedullary nailing, irrigation and debridement, and antibiotic beads. Standard postoperative hospital care was provided, and after 2 days of intravenous antibiotics, the patient was returned to the operating room for removal of the antibiotic beads and a delayed primary closure. At the most recent follow-up, over 1 year postinjury, he had radiographic healing and was asymptomatic. Although it is difficult to predict whether the stress riser created by a nail gun injury will lead to a fracture, weight-bearing status and the aggressiveness of treatment to prevent infection are factors that need to be carefully considered in patients with this type of injury.

Vitamin D supplementation in underway submariners.

INTRODUCTION: We assessed the efficacy of vitamin D supplementation in maintaining normal calcium and bone homeostasis in underway submariners deprived of sunlight. METHODS: Serum 25-hydroxycholecalciferol (25(OH)D), 1,25-dihydroxycholecalciferol (1,25(OH)2D), calcium, parathyroid hormone (PTH), phosphate, osteocalcin, bone specific alkaline phosphatase, and urinary levels of N-telopeptide were examined in 51 subjects aboard a submarine. These levels were obtained prior to a 76-d deployment, before and after a 6-d liberty period (deployment day 49 and 55), and on return to homeport. There were 26 subjects who received 400-lU of vitamin D daily supplementation, and 25 who received placebo. RESULTS: Both groups exhibited significant reductions in 25(OH)D levels in the initial submergence (a decrease from 28.3 +/- 15 ng x ml(-1) to 24.1 +/- 10 ng x ml(-1) in the experimental group and 26.3 +/- 10 ng x ml(-1) to 20.7 +/- 9 ng x ml(-1) in the controls), an increase in 25(OH)D levels not significantly different from baseline during the liberty period, and decrements in 25(OH)D on repeat submergence (22.8 +/- 10 ng x ml(-1) in experimental and 21.4 +/- 10 ng x ml(-1) in controls). Both groups exhibited an increase in post-liberty osteocalcin (20.4 +/- 6 ng x ml(-1) to 24.5 +/- 5 ng x ml(-1) for experimental and 18.3 +/- 6 to 23.5 +/- 7 ng x ml(-1) for controls), and stable serum calcium levels throughout the patrol. CONCLUSIONS: 400-IU daily vitamin D supplementation was insufficient in maintaining serum vitamin D levels in underway submariners, engendering biochemical evidence of bone resorption and turnover. Six d sunlight exposure compensated for 49 d sunlight absence, supporting the enormous capacity of UV-B mediated vitamin D production.