Ground-Based Pyrethroid Adulticides Reduce Mosquitoes But Not Nontarget Insects in Central Florida.

As stewards of public and environmental health, mosquito control agencies are rightfully concerned about impacts on nontarget organisms. This study examined the impact of a modern, pyrethroid based ground adulticide program using ultra-low volume applications in a metropolitan county in central Florida. Nontarget insects and mosquitoes were collected in a before-after control-impact design at 21 sites over 1.5 years. While mosquitoes were reduced, we found no evidence for reduction of nontarget insects, regardless of taxon. Night-flying Lepidoptera may experience greater risk than other nontarget taxa, but overall effects of adulticide missions on this group were low and inconsistent. Instead, meteorology, habitat, and phenology dominate patterns of nontarget abundance. Mosquito reduction was more clearly observed and corrected post-mission reduction was consistent with results expected in complex urban and suburban treatment zones.

Experimental disturbance and productivity gradients drive community diversity in aquatic mesocosms.

Combined effects of disturbance and productivity on ecological diversity have been considered for decades as the dynamic equilibrium model (DEM) but are rarely tested together. Instead, most studies focus on either the intermediate disturbance hypothesis or sometimes the intermediate productivity hypothesis. In addition, most analyses of disturbance and productivity effects have relied on nonexperimental patterns, limited sample sizes, inaccurate proxies for productivity, and/or simple measures of diversity. The DEM operates at regional and local scales; here, we conducted a year-long experiment at local scales using submersed aquatic vegetation in outdoor mesocosms with a factorial combination of physical disturbance and productivity treatments. We evaluated diversity in several ways, directly measured productivity, and compared alternative hypotheses using model selection. The DEM was supported for effective diversity; both productivity and disturbance effects were clear, though productivity effects were stronger. Other diversity measures for the simple communities in the mesocosms did not clearly reflect treatments. The DEM is a valuable general framework for understanding disturbance and productivity effects on ecological systems and is made more general by minor conceptual adjustments here.

Bioinspired Total Synthesis of Erectones A and B, and the Revised Structure of Hyperelodione D.

The field of biomimetic synthesis seeks to apply biosynthetic hypotheses to the efficient construction of complex natural products. This approach can also guide the revision of incorrectly assigned structures. Herein, we describe the evolution of a concise total synthesis and structural reassignment of hyperelodione D, a tetracyclic meroterpenoid derived from a Hypericum plant, alongside some biogenetically related natural products, erectones A and B. The key step in the synthesis of hyperelodione D forms six stereocentres and three rings in a bioinspired cascade reaction that features an intermolecular Diels-Alder reaction, an intramolecular Prins reaction and a terminating cycloetherification.

Bisketene Equivalents as Diels-Alder Dienes.

2,5-Bis(tert-butyldimethylsilyloxy)furans are established as vicinal bisketene equivalents for application as dienes in the Diels-Alder reaction. Cycloaddition with olefinic dienophiles, under exceptionally mild conditions, enables convergent access to highly substituted para-hydroquinones in unprotected form via a one-pot Diels-Alder/ring-opening/tautomerization sequence. The synthesis of para-benzoquinones from acetylenic dienophiles, including benzynes, is also demonstrated, and 2,5-bis(tert-butyldimethylsilyloxy)pyrroles are established as competent dienes for the synthesis of para-iminoquinones. Application in natural product synthesis enables gram-scale access to the neuroprotective agent (±)-indanostatin.

Visible-Light Photoredox Catalysis Enables the Biomimetic Synthesis of Nyingchinoids†A, B, and D, and Rasumatranin†D.

The total synthesis of nyingchinoids A and B has been achieved through successive rearrangements of a 1,2-dioxane intermediate that was assembled using a visible-light photoredox-catalysed aerobic [2+2+2] cycloaddition. Nyingchinoid D was synthesised with a competing [2+2] cycloaddition. Based on NMR data and biosynthetic speculation, we proposed a structure revision of the related natural product rasumatranin D, which was confirmed through total synthesis. Under photoredox conditions, we observed the conversion of a cyclobutane into a 1,2-dioxane through retro-[2+2] cycloaddition followed by aerobic [2+2+2] cycloaddition.