Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.

The most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer was published in 2022. It was therefore decided, by both the ESMO and the Indian Society of Medical and Paediatric Oncology (ISMPO), to convene a virtual meeting in July 2022 to adapt the ESMO 2022 guidelines to take into account the variations in the management of endometrial cancer in Asia. These guidelines represent the consensus opinion of a panel of Asian experts representing the oncological societies of China (CSCO), India (ISMPO), Indonesia (ISHMO), Japan (JSMO), Korea (KSMO), Malaysia (MOS), the Philippines (PSMO), Singapore (SSO), Taiwan (TOS) and Thailand (TSCO). Voting was based on scientific evidence and was conducted independently of the current treatment practices and treatment access constraints in the different Asian countries, which were discussed when appropriate. The aim of this guideline manuscript is to provide guidance for the optimisation and harmonisation of the management of patients with endometrial cancer across the different regions of Asia, drawing on the evidence provided by Western and Asian trials whilst respecting the variations in clinical presentation, diagnostic practices including molecular profiling and disparities in access to therapeutic options, including drug approvals and reimbursement strategies.

New peperomin and polyketides from dichloromethane extract of Peperomia blanda Jack. (Kunth).

Much of the new research and investigation in pharmacy sciences are concerned with developing therapeutic agents, and identifying and finding new drugs with their chemical structure to treat different human diseases such as infectious diseases from natural products. Therefore, the present findings relate to isolating five new compounds the dichloromethane extract of Peperomia blanda (Jacq.) Kunth grown on Socotra Island, Yemen. two new secolignans; which have been proposed as peperomin I & J. These compounds were isolated together with the other two polyketides presented as surinone D and dindygulerione F. The chemical structures were elucidated and confirmed with nuclear magnetic resonance (NMR) and liquid chromatography-mass spectroscopy (LCMS) analysis. These compounds were first isolated and reported from this plant. These new compounds' antimicrobial activity has been evaluated, and minimum inhibitory concentration has been recorded in the range of 125-250 µg/mL. The pharmacotherapeutic spectrum of compounds was predicated using PASS software which showed potential activity.

Sociodemographic Factors of Depression During the COVID-19 Pandemic in Malaysia: the COVID-19 Mental Health International Study.

OBJECTIVES: To determine the prevalence of depression and the sociodemographic factors associated with depression in Malaysia during the COVID-19 pandemic METHODS. This study is part of the COVID-19 Mental Health International Study to collect data on the impact of the pandemic on mental health through an online survey. People who were aged ≥18 years, able to read Malay or English, had access to the internet, and consented to participate were asked to complete a pro forma questionnaire to collect their sociodemographic data. The presence of distress and depression was assessed using the English or Malay version of the Center for Epidemiologic Studies Depression Scale. RESULTS: Of 963 participants, 451 (46.8%) had depression and 512 (53.2%) had no depression who were either normal (n = 169, 17.5%) or had distress (n = 343, 35.6%). Participants had higher odds of having depression when living with two people (adjusted odds ratio [AOR] = 3.896, p = 0.001), three people (AOR = 2.622, p < 0.001) or four people (AOR = 3.135, p < 0.001). Participants with three children had higher odds of having depression (AOR = 2.084, p = 0.008), whereas having only one child was a protective factor for depression (AOR = 0.481, p = 0.01). Participants had higher odds of having depression when self-employed (AOR = 3.825, p = 0.003), retired (AOR = 4.526, p = 0.001), being housekeeper (AOR = 7.478, p = 0.004), not working by choice (AOR = 5.511, p < 0.001), or unemployed (AOR = 3.883, p = 0.009). Participants had higher odds of depression when living in a small town (AOR = 3.193, p < 0.001) or rural area (AOR = 3.467, p < 0.001). Participants with no chronic medical illness had lower odds of having depression (AOR = 0.589, p = 0.008). CONCLUSION: In Malaysia during the COVID-19 pandemic, people who are living with two, three, or four people, having three children, living in a small town or rural areas, and having unstable income have higher odds of having depression. Urgent intervention for those at risk of depression is recommended.

Exploration of cassava plant xylem for water treatment: preparation, characterization and filtration capability.

Flood is among the natural disasters that commonly happened in Malaysia every year. During the flood, victims faced clean water shortages and deterioration of the environment resulting in long waiting times for aid to access. Hence, affordable and efficient filters are needed to supply clean water in the affected areas. Application of xylem tissue inside plant stem has the potential as a filter for water filtration. This research focuses on xylem tissue in Malaysian tropical plants from cassava stem. Cassava stems were prepared in a small-scale set-up as the xylem was used as a filter. Effects of cross-sectional area and hydrostatic pressure were analyzed and the results showed a directly proportional relationship with permeate flow rate. Upon filtration with red dye solution, total dye removal was achieved using a xylem with a minimal length of 3 cm and onwards. While for bacteria removal, E. coli bacteria have been removed when tested with a bacteria count plate. Thus, this study demonstrated the potential of the xylem tissue of the cassava plant as affordable and available natural raw materials to be used as water filters during an emergency.

Ionic Transport Properties of Cation-Exchange Membranes Prepared from Poly(vinyl alcohol-b-sodium Styrene Sulfonate).

Membrane resistance and permselectivity for counter-ions have important roles in determining the performance of cation-exchange membranes (CEMs). In this study, PVA-based polyanions-poly(vinyl alcohol-b-sodium styrene sulfonate)-were synthesized, changing the molar percentages CCEG of the cation-exchange groups with respect to the vinyl alcohol groups. From the block copolymer, poly(vinyl alcohol) (PVA)-based CEMs, hereafter called "B-CEMs", were prepared by crosslinking the PVA chains with glutaraldehyde (GA) solution at various GA concentrations CGA. The ionic transport properties of the B-CEMs were compared with those previously reported for the CEMs prepared using a random copolymer-poly(vinyl alcohol-co-2-acrylamido-2-methylpropane sulfonic acid)-hereafter called "R-CEMs". The B-CEMs had lower water content than the R-CEMs at equal molar percentages of the cation-exchange groups. The charge density of the B-CEMs increased as CCEG increased, and reached a maximum value, which increased with increasing CGA. A maximum charge density of 1.47 mol/dm3 was obtained for a B-CEM with CCEG = 2.9 mol% and CGA = 0.10 vol.%, indicating that the B-CEM had almost two-thirds of the permselectivity of a commercial CEM (CMX: ASTOM Corp. Japan). The dynamic transport number and membrane resistance of a B-CEM with CCEG = 8.3 mol% and CGA = 0.10 vol.% were 0.99 and 1.6 Ωcm2, respectively. The B-CEM showed higher dynamic transport numbers than those of the R-CEMs with similar membrane resistances.

A rare and unusual cause of Vibrio cholerae non-O1, non-O139 causing spontaneous peritonitis in a patient with cirrhosis.

Spontaneous bacterial peritonitis caused by Vibrio cholerae non-O1/ non-O139 is a rare phenomenon. V. cholerae is known as a common aetiology of epidemic diarrheal disease and rarely causes extra-gastrointestinal infections. In this report, a 52-year-old man presented to our hospital with a clinical scenario for chronic liver cirrhosis with low grade fever and loose stools. V. cholerae was isolated from peritoneal fluid culture, which was further confirmed as non-O1/ non-O139 strain by multiplex polymerase chain reaction. The patient was successfully treated with antimicrobial therapy and peritoneal drainage. This case represents the first isolation of V. cholerae non-O1/ non-O139 strain from peritoneal fluid.

Video Game-Based Rehabilitation Approach for Individuals Who Have Undergone Upper Limb Amputation: Case-Control Study.

BACKGROUND: Brain plasticity is an important factor in prosthesis usage. This plasticity helps with brain adaptation to learn new movement and coordination patterns needed to control a prosthetic hand. It can be achieved through repetitive muscle training that is usually very exhausting and often results in considerable reduction in patient motivation. Previous studies have shown that a playful concept in rehabilitation can increase patient engagement and perseverance. OBJECTIVE: This study investigated whether the inclusion of video games in the upper limb amputee rehabilitation protocol could have a beneficial impact for muscle preparation, coordination, and patient motivation among individuals who have undergone transradial upper limb amputation. METHODS: Ten participants, including five amputee participants and five able-bodied participants, were enrolled in 10 1-hour sessions within a 4-week rehabilitation program. In order to investigate the effects of the rehabilitation protocol used in this study, virtual reality box and block tests and electromyography (EMG) assessments were performed. Maximum voluntary contraction was measured before, immediately after, and 2 days after interacting with four different EMG-controlled video games. Participant motivation was assessed with the Intrinsic Motivation Inventory (IMI) questionnaire and user evaluation survey. RESULTS: Survey analysis showed that muscle strength and coordination increased at the end of training for all the participants. The results of Pearson correlation analysis indicated that there was a significant positive association between the training period and the box and block test score (r8=0.95, P<.001). The maximum voluntary contraction increment was high before training (6.8%) and in the follow-up session (7.1%), but was very small (2.1%) shortly after the training was conducted. The IMI assessment showed high scores for the subscales of interest, perceived competence, choice, and usefulness, but low scores for pressure and tension. CONCLUSIONS: This study demonstrated that video games enhance motivation and adherence in an upper limb amputee rehabilitation program. The use of video games could be seen as a complementary approach for physical training in upper limb amputee rehabilitation.

A rare and unusual cause of Vibrio cholerae non-O1, non-O139 causing spontaneous peritonitis in a patient with cirrhosis

@#Spontaneous bacterial peritonitis caused by Vibrio cholerae non-O1/ non-O139 is a rare phenomenon. V. cholerae is known as a common aetiology of epidemic diarrheal disease and rarely causes extra-gastrointestinal infections. In this report, a 52-year-old man presented to our hospital with a clinical scenario for chronic liver cirrhosis with low grade fever and loose stools. V. cholerae was isolated from peritoneal fluid culture, which was further confirmed as non-O1/ non-O139 strain by multiplex polymerase chain reaction. The patient was successfully treated with antimicrobial therapy and peritoneal drainage. This case represents the first isolation of V. cholerae non-O1/ non-O139 strain from peritoneal fluid.

Methanol outbreak: a Malaysian tertiary hospital experience.

INTRODUCTION: Methanol poisoning usually occurs in a cluster and initial diagnosis can be challenging. Mortality is high without immediate interventions. This paper describes a methanol poisoning outbreak and difficulties in managing a large number of patients with limited resources. METHODOLOGY: A retrospective analysis of a methanol poisoning outbreak in September 2018 was performed, describing patients who presented to a major tertiary referral centre. RESULT: A total of 31 patients were received over the period of 9 days. Thirty of them were males with a mean age of 32 years old. They were mostly foreigners. From the 31 patients, 19.3% were dead on arrival, 3.2% died in the emergency department and 38.7% survived and discharged. The overall mortality rate was 61.3%. Out of the 12 patients who survived, two patients had toxic optic neuropathy, and one patient had uveitis. The rest of the survivors did not have any long-term complications. Osmolar gap and lactate had strong correlations with patient's mortality. Serum pH, bicarbonate, lactate, potassium, anion gap, osmolar gap and measured serum osmolarity between the alive and dead patients were significant. Post-mortem findings of the brain were unremarkable. CONCLUSION: The mortality rate was higher, and the morbidity includes permanent visual impairment and severe neurological sequelae. Language barrier, severity of illness, late presentation, unavailability of intravenous ethanol and fomipezole and delayed dialysis may have been the contributing factors. Patient was managed based on clinical presentation. Laboratory parameters showed difference in median between group that survived and succumbed for pH, serum bicarbonate, lactate, potassium and osmolar and anion gap. Management of methanol toxicity outbreak in resource-limited area will benefit from a well-designed guideline that is adaptable to the locality.

Environmental assessment of heavy metal pollutants in soils and water from Ortum, Kenya.

Analysis of elemental concentration in soil and water was carried out in Ortum to ensure safe utilization of soil and water resources for agriculture, industrial, and household purposes. Elemental analysis of soil and water was done using the EDXRF spectrometer and the inductively coupled plasma - optical emission spectrometry (ICP-OES), respectively. A total of 59 soil samples from different locations and depth and 10 water samples were collected from Ortum using purposive sampling method. The results of the mean elemental composition of 13 elements Ni (ppm), Cu (ppm), Zn (ppm), Pb (ppm), K (%w), Ca (%w), Fe (%w), Ti (%w), Mn (ppm), Rb (ppm), Sr (ppm), Zr (ppm), and Nb (ppm) in soils were 58.11, 46.91, 73.49, 22.20, 3.83, 24.39, 1.72, 7.73, 1529.74, 60.98, 442.26, 410.63, and 29.36, respectively, and the mean of 19 elements Ni, Cu, Pb, Zn, Ag, Al, As, Ba, Ca, Cd, Co, Cr, Fe, K, Mg, Mn, Mo, Na, and Se in water samples in (mg/l) were 0.037, 0.0014, 0.0005, 0.0042, 0.0030, 0.021, 0.0080, 0.12, 73.81, 0.00023, 0.0036, 0.00276, 0.0040, 6.11, 38.18, 0.00023, 0.0032, 46.87, and 0.0026, respectively. The average elemental concentration in soils was within the world average range. The mean concentration of Cu, Zn, and Pb in soil reduced with increase in depth while that of Ni increased with increase in depth. The average metal pollution indices in soils, geoaccumulation index (Igeo) potential ecological risk index (Ei), and synthesized potential ecological risk index (Er) were evaluated and found to be - 0.40, 4.92, and 19.69, respectively. According to the classification index, the results show that the soil in Ortum is moderately polluted, and the risk associated with the measured elemental concentration of Ni, Zn, Cu, and Pb in the soils is low. The elemental concentrations in water samples was lower than the recommended permissible limits except for Calcium (Ca) in borehole water with an average of 90.80 mg/l against the permissible levels of 75 mg/l (WHO, 2011). The pH for water samples was found to range from 6.60 to 7.71 with an average of 7.07 which is within the acceptable range of pH 6.5 to pH 8.5 as recommended by WHO, 2011. The study found out that elemental concentration in soil and water samples from Ortum were withing the world average values and that the soil and water in Ortum is safe for use in agriculture and domestic purposes.

NATURALLY OCCURRING RADIONUCLIDES IN SOIL SAMPLES OF BURETI SUB-COUNTY OF KERICHO COUNTY KENYA.

The activity concentration of soil samples of Bureti sub-county was measured using thallium-activated sodium iodide detector. To ascertain the level of radiation hazard to the public, gamma radiation dose rates were also estimated. The average activity concentration due to 40K, 226Ra and 232Th for soil samples are 1164 ± 70, 106 ± 8 and 79 ± 5 Bqkg-1, respectively. An average dose rate of 145 ± 10 nGyh-1 was recorded, which is about 2.5 times higher than the world average value of 60 nGyh-1(UNSCEAR). On the other hand, an average outdoor effective dose of 0.35 ± 0.02 mSvy-1 was measured, which is lower than the ICRP safety limit of 1 mSvy-1. This shows that the radiation hazards from naturally occurring terrestrial radionuclides in Bureti is low and therefore human radiation exposure is within the accepted limits.

HUMAN EXPOSURE TO BACKGROUND RADIATION IN ORTUM, KENYA.

The activity concentration of radionuclides 238U, 232Th and 40K in soil and the absorbed dose rate (ADRA) at 1 m above the ground in Ortum was determined. The activity concentration in soils ranged from 33 to 85, 20 to 67 and 148-1019 Bq kg-1, respectively with an average of 40 ± 1.43, 56 ± 1.46 and 425 ± 19.24 Bq kg-1, respectively. The activity concentration of 232Th and 238U was found to reduce with increasing depth while that of 40K increased with increasing depth. The average activity concentration in soil was higher than the world average values. The average ADRA in air at 1 m above the ground was found to be 112 ± 29.6 nGy h-1. The soil and rocks in Ortum are recommended for use because the activity concentration of the terrestrial radionuclides is lower than the recommended threshold values.

ANNUAL EFFECTIVE DOSE ASSESSMENT DUE TO RADON AND THORON PROGENIES IN DWELLINGS OF KILIMAMBOGO, KENYA.

Human beings are continuously exposed to ionising radiation originating from natural or artificial sources. Uranium-238 and Thorium-232 found in building materials are important sources of radon and thoron in the indoor environment. The concentration levels of radon, thoron and thoron progeny were measured in mud-walled, metallic or iron sheet-walled and stone-walled modern houses in Kilimambogo region, Kenya for 3 months. Radon and thoron concentration levels were measured using passive radon-thoron discriminative monitors (RADUET), while thoron progeny concentrations as the equilibrium equivalent thoron concentration (EETC) were measured using thoron progeny monitors. The mean radon concentration levels in mud, metallic and stone-walled dwellings were 67 ± 11, 60 ± 10 and 75 ± 10 Bq m-3, respectively. The mean thoron concentration levels in the corresponding dwellings were 195 ± 36, 71 ± 24 and 161 ± 31 Bq m-3, respectively, while EETCs were 12 ± 2, 3 ± 1 and 7 ± 1 Bq m-3, respectively. The annual effective doses for radon were 1.3 ± 0.2, 1.1 ± 0.1 and 1.4 ± 0.2 mSv y-1 in mud, metallic and stone-walled houses while those from thoron estimated from EETC were 2.4 ± 0.4, 0.5 ± 0.1 and 1.5 ± 0.2 mSv y-1 in the corresponding houses, respectively.

Phytochemical screening, cytotoxic and antimicrobial activities of Limonium socotranum and Peperomia blanda extracts.

Limonium socotranum and Peperomia blanda are used in ethnomedicine to treat several diseases, such as infection, cancer, and inflammation. P. blanda (family: Piperaceae) is from the genus Peperomia, and mostly found in Madagascar, Yemen, USA to South America, while L. socotranum (family: Plumbaginaceae) from the genus Limonium and this species is found only on Socotra Island, Yemen. These plants have attracted great interest in recent years because of their phytochemical contents. Consequently, the current study is aimed to investigate the phytochemical constituents, the cytotoxic and antimicrobial activities of L. socotranum (leaves and stem) and P. blanda extracts. Successive extraction had been performed which resulted in nine crude extracts. Phytochemical screening of the extracts was then conducted using qualitative chemical analysis. The antimicrobial activity of the plant extracts was determined using the well diffusion method against eleven selected pathogenic microbes and the minimum inhibitory concentrations (MIC) were measured. The cytotoxic activities of the plant extracts against MCF-7 and HepG2 cell lines were investigated using sulforhodamine B assay. It was noted that methanol leaves extract from L. socotranum exhibited higher antibacterial activity against Micrococcus luteus (MIC 15.6 µg/mL), Staphylococcus aureus (MIC 125 µg/mL) and Pseudomonas aeruginosa (MIC 125 µg/mL), than stem parts, while petroleum ether extract displayed stronger antifungal activity, with MIC of 125 µg/mL. On the other hand, petroleum ether extract of P. blanda was effective against Gram-positive bacteria and exhibited moderate antifungal activity. Petroleum ether extract of P. blanda displayed cytotoxic activity against MCF-7 cells, with an IC50 of 4.60 ± 0.02 µg/mL, while the methanol extracts showed higher activity against the HepG2 cell line, with an IC50 of 13.90 ± 0.14 µg/mL. Phytochemical findings confirmed the presence of flavonoids, alkaloids and terpenoids. The promising obtained results suggest the potential use of these plants in cancer and antimicrobial therapies.

Phytochemical screening, cytotoxic and antimicrobial activities of Limonium socotranum and Peperomia blanda extracts

@#Limonium socotranum and Peperomia blanda are used in ethnomedicine to treat several diseases, such as infection, cancer, and inflammation. P. blanda (family: Piperaceae) is from the genus Peperomia, and mostly found in Madagascar, Yemen, USA to South America, while L. socotranum (family: Plumbaginaceae) from the genus Limonium and this species is found only on Socotra Island, Yemen. These plants have attracted great interest in recent years because of their phytochemical contents. Consequently, the current study is aimed to investigate the phytochemical constituents, the cytotoxic and antimicrobial activities of L. socotranum (leaves and stem) and P. blanda extracts. Successive extraction had been performed which resulted in nine crude extracts. Phytochemical screening of the extracts was then conducted using qualitative chemical analysis. The antimicrobial activity of the plant extracts was determined using the well diffusion method against eleven selected pathogenic microbes and the minimum inhibitory concentrations (MIC) were measured. The cytotoxic activities of the plant extracts against MCF-7 and HepG2 cell lines were investigated using sulforhodamine B assay. It was noted that methanol leaves extract from L. socotranum exhibited higher antibacterial activity against Micrococcus luteus (MIC 15.6 μg/mL), Staphylococcus aureus (MIC 125 μg/mL) and Pseudomonas aeruginosa (MIC 125 μg/mL), than stem parts, while petroleum ether extract displayed stronger antifungal activity, with MIC of 125 μg/mL. On the other hand, petroleum ether extract of P. blanda was effective against Gram-positive bacteria and exhibited moderate antifungal activity. Petroleum ether extract of P. blanda displayed cytotoxic activity against MCF-7 cells, with an IC50 of 4.60 ± 0.02 μg/mL, while the methanol extracts showed higher activity against the HepG2 cell line, with an IC50 of 13.90 ± 0.14 μg/mL. Phytochemical findings confirmed the presence of flavonoids, alkaloids and terpenoids. The promising obtained results suggest the potential use of these plants in cancer and antimicrobial therapies.

A Case of Medialized Lateral Maxillary Sinus Wall: A Pillar of Support.

The number of maxillofacial trauma (MFT) cases attended in the Emergency Department is progressively increasing in trend, owing to the rising statistics of motor-vehicle accidents (MVAs) and urban assaults in addition to occupational-related injuries. Prompt and thorough assessment is important for accurate diagnosis and paramount treatment plans. We will be discussing a case of unusual presentation of an orbital floor fracture post-MVA which was treated conservatively based on the clinical assessments during follow-ups, supported by radiological findings. We will also briefly discuss the different radiological modalities available in assessing MFT and late presentation of enophthalmos.

Optimization of the Synthesis of Superhydrophobic Carbon Nanomaterials by Chemical Vapor Deposition.

Demand is increasing for superhydrophobic materials in many applications, such as membrane distillation, separation and special coating technologies. In this study, we report a chemical vapor deposition (CVD) process to fabricate superhydrophobic carbon nanomaterials (CNM) on nickel (Ni)-doped powder activated carbon (PAC). The reaction temperature, reaction time and H2/C2H2 gas ratio were optimized to achieve the optimum contact angle (CA) and carbon yield (CY). For the highest CY (380%) and CA (177°), the optimal reaction temperatures were 702 °C and 687 °C, respectively. However, both the reaction time (40 min) and gas ratio (1.0) were found to have similar effects on CY and CA. Based on the Field emission scanning electron microscopy and transmission electron microscopy images, the CNM could be categorized into two main groups: a) carbon spheres (CS) free carbon nanofibers (CNFs) and b) CS mixed with CNFs, which were formed at 650 and 750 °C, respectively. Raman spectroscopy and thermogravimetric analysis also support this finding. The hydrophobicity of the CNM, expressed by the CA, follows the trend of CS-mixed CNFs (CA: 177°) > CS-free CNFs (CA: 167°) > PAC/Ni (CA: 65°). This paves the way for future applications of synthesized CNM to fabricate water-repellent industrial-grade technologies.

Putative periodontal pathogens in the subgingival plaque of Sudanese subjects with aggressive periodontitis.

BACKGROUND AND OBJECTIVES: There has been limited study of the bacterial species associated with aggressive periodontitis (AgP) in high-risk populations in Africa. The aim of this study was to investigate and quantify the presence of four putative periodontal pathogens in the subgingival plaque of Sudanese subjects with AgP. A secondary aim was to investigate the effect of varying the detection threshold on the reported prevalence of the bacterial species investigated. MATERIALS AND METHODS: Subgingival plaque samples were collected from AgP cases (n=73) and healthy controls (n=71). Bacterial DNA was extracted and analyzed by quantitative polymerase chain reaction for the detection and quantification of four putative periodontal pathogens: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola and Tannerella forsythia. RESULTS: At the lowest detection threshold (>101 cells), P. gingivalis (p<0.0001) was more prevalent in AgP cases than controls. T. forsythia and T. denticola had a high prevalence (>70%) in AgP cases at all detection levels. While T. forsythia was significantly more frequently identified in AgP than in controls at all detection thresholds, this was only the case for T. denticola at the intermediate threshold (>102 cells). A. actinomycetemcomitans was identified less frequently than the other bacterial species with no difference in its prevalence between AgP cases and controls. CONCLUSION: The prevalence of the putative periodontal pathogens investigated varied considerably in Sudanese subjects with AgP and in periodontally healthy controls depending on the detection thresholds applied. T. forsythia was identified as having the strongest association with AgP.

An anthropomorphic transhumeral prosthesis socket developed based on an oscillometric pump and controlled by force-sensitive resistor pressure signals.

While considering the importance of the interface between amputees and prosthesis sockets, we study an anthropomorphic prosthesis socket whose size can be dynamically changed according to the requirements of the residual limb. First, we introduce the structure and function of the anthropomorphic prosthesis socket. Second, we study the dynamic model of the prosthesis system and analyze the dynamic characteristics of the prosthesis socket system, the inputs of an oscillometric pump, and the control mechanism of force-sensitive resistor (FSR) pressure signals. Experiments on 10 healthy subjects using the designed system yield an average detection result between 102 and 112 kPa for the FSR pressure sensor and 39 and 41 kPa for the oscillometric pump. Results show the function of the FSR pressure signal in maintaining the contact pressure between the sockets and the residual limb. The potential development of an auto-adjusted socket that uses an oscillometric pump system will provide prosthetic sockets with controllable contact pressure at the residual limb. Moreover, this development is an attractive research area for researchers involved in rehabilitation engineering, prosthetics, and orthotics.