1.
J Clin Monit Comput
; 27(6): 703-4, 2013 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23756998
2.
Bioorg Med Chem
; 10(7): 2103-10, 2002 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11983506
RESUMO
A practical method of synthesizing a highly selective EP4-receptor agonist 1 using Corey lactone 2 as a key intermediate was developed. Selective methanesulfonylation of the primary alcohol of the diol 8 under the newly devised conditions followed by the protection of the remaining secondary alcohol are key reactions in this new method. Further biological evaluation of 1a-b is also reported.