A prospective trial of short-course radiotherapy plus chemotherapy for palliation of dysphagia from advanced esophageal cancer.

PURPOSE: Between 1994 and 1997, 22 patients with dysphagia from advanced incurable esophageal cancer were enrolled in a phase I/II prospective study to assess the palliative benefit and toxicity of a short course of radiotherapy with chemotherapy. METHODS: The study population included 17 men and five women with a median age of 69 (range 43-84). Patients were treated with 30 Gy in ten fractions to the mediastinum with a concurrent single course of chemotherapy (5-FU, 1000 mg/m(2), days 1-4 and mitomycin-C 10 mg/m(2), day 1). Swallowing ability was recorded each day on a self-administered diary card using the five point dysphagia index of the MRC (UK). The median baseline MRC swallowing score was 4 (cannot swallow solids). RESULTS: Treatment was generally well tolerated, but seven (32%) patients had transient worsening of dysphagia scores immediately following treatment because of esophagitis; fifteen (68%) achieved a complete response (score 1: no difficulty on swallowing) with a median time to normalization of swallowing of 5 weeks. For these patients, the median dysphagia-free interval from time of onset of improvement was 11 weeks (range 1-131 weeks) and 11 (73%) remained dysphagia-free until death. The remaining patients had no or marginal improvement. Univariate analysis showed no difference between responders and non-responders with respect to age, gender, or histology. Median survival for the entire study population was 20 weeks (range 3-135 weeks). CONCLUSIONS: This prospective trial shows that a short course of radiotherapy plus chemotherapy may produce complete relief of swallowing difficulties in a substantial proportion of patients with acceptable toxicity.

Baring the sole. The rise and fall of the shoe-fitting fluoroscope.

One of the most conspicuous nonmedical uses of the x-ray was the shoe-fitting fluoroscope. It allowed visualization of the bones and soft tissues of the foot inside a shoe, purportedly increasing the accuracy of shoe fitting and thereby enhancing sales. From the mid 1920s to the 1950s, shoe-fitting fluoroscopes were a prominent feature of shoe stores in North America and Europe. Despite the widespread distribution and popularity of these machines, few have studied their history. In this essay we trace the origin, technology, applications, and significance of the shoe-fitting fluoroscope in Britain, Canada, and the United States. Our sources include medical and industrial literature, oral and written testimony of shoe retailers, newspapers, magazines, and government reports on the uses and dangers of these machines. The public response to shoe-fitting fluoroscopes changed from initial enthusiasm and trust to suspicion and fear, in conjunction with shifting cultural attitudes to radiation technologies.

The management and outcome of bladder carcinoma in Ontario, 1982-1994.

BACKGROUND: To the authors' knowledge no previous study has described the management and outcome of bladder carcinoma on a population-based level. The objective of the current study was to describe the characteristics, treatment, and outcome of newly diagnosed invasive bladder carcinoma (n = 20,822) reported in Ontario, Canada between 1982-1994. METHODS: Electronic records of invasive bladder carcinoma (International Classification of Diseases code 188) from the Ontario Cancer Registry were linked to surgical and radiotherapy (RT) records. Bivariate and multivariate techniques were used to assess variations in the use of initial cystectomy and pelvic RT. The authors modeled the likelihood of death after diagnosis and the probability of cystectomy free survival. All analyses were controlled for age, gender, histology, and year of diagnosis. RESULTS: The most common histologic type was papillary transitional cell carcinoma. Maximum initial treatment was comprised of total cystectomy (5.1%), partial cystectomy or open excision (3. 5%), pelvic RT (5.9%), transurethral resection of the bladder (66. 7%), or lesser or no procedures (18.7%). The use of total cystectomy and pelvic RT varied among the regions of Ontario. Overall 5-year survival was 58.8%, and was 86.5% for patients with papillary histology. In multivariate analysis, although survival was similar among the regions, the relative risk of cystectomy conditional on survival varied. CONCLUSIONS: Papillary tumors portend a better survival than nonpapillary tumors. Variations in the use of total cystectomy and in the use of pelvic RT among the regions of Ontario did not appear to be associated with variations in survival. However, cystectomy free survival appeared to vary among the regions. These results suggest that patients can be managed safely using a bladder-preserving approach.

A population-based study of the use and outcome of radical radiotherapy for invasive bladder cancer.

PURPOSE: The objective of this study is to describe the use and outcome of radical radiotherapy for bladder cancer in the province of Ontario, Canada, between 1982 and 1994. METHODS: Electronic records of invasive bladder cancer (ICD code 188) from the Ontario Cancer Registry were linked to surgical records from all Ontario hospitals and radiotherapy (RT) records from all Ontario cancer centers. We identified cases receiving radical RT by selecting RT records containing "bladder" or "pelvis" anatomic region codes and a radical or curative intent code (or dose >39.5 Gy if intent missing). We identified cases receiving salvage total cystectomy by selecting total cystectomy procedure codes occurring at any time beyond 4 months from the start of radical RT. We used life table methods to compute the following: the time from diagnosis to radical RT, the time from radical RT to salvage cystectomy, overall and cause-specific survival from radical radiotherapy to death, and overall and cause-specific survival from salvage cystectomy to death. We modeled the factors associated with time to death, time to cystectomy conditional on survival, and time to cystectomy or death, whichever came first, using Cox proportional hazards regression. RESULTS: From the 20,906 new cases of bladder cancer diagnosed in Ontario from 1982 to 1994, we identified 1,372 cases treated by radical radiotherapy (78% male, 22% female; mean age 69.8 years). The median interval to start of radical RT from diagnosis was 13.4 weeks. Ninety-three percent of patients were treated on high-energy linacs, and the most common dose/fractionation scheme was 60 Gy/30 (31% of cases). Five-year survival rates were as follows: bladder cancer cause-specific, 41%; overall, 28%; cystectomy-free, 25%; bladder cancer cause-specific following salvage cystectomy, 36%; overall following salvage cystectomy, 28%. Factors associated with a higher risk of death and a poorer cystectomy-free survival were histology (squamous or nonpapillary transitional cell carcinoma [TCC]) and advanced age. CONCLUSION: This population-based study confirms previous institutional studies and clinical trials and shows that radical RT has a curative role in the management of invasive bladder cancer and allows about one-quarter of patients receiving radiotherapy to survive 5 years while retaining the bladder. Salvage cystectomy following RT provides a chance of cure at the time of bladder relapse.

A real-time audit of radiation therapy in a regional cancer center.

PURPOSE: To report the development, structure, and implementation of a real-time clinical radiotherapy audit of the practice of radiation oncology in a regional cancer center. METHODS AND MATERIALS: Radiotherapy treatment plans were audited by a real-time peer-review process over an 8-year period (1989-1996). The overall goal of the audit was to establish a process for quality assurance (QA) of radiotherapy planning and prescription for individual patients. A parallel process was developed to audit the implementation of intervention-specific radiotherapy treatment policies. RESULTS: A total of 3052 treatment plans were audited. Of these, 124 (4.1%) were not approved by the audit due to apparent errors in radiation planning. The majority of the nonapproved plans (79%) were modified prior to initiating treatment; the audit provided important clinical feedback about individual patient care in these instances. Most of the remaining nonapproved plans were deviations from normal practice due to patient-specific considerations. A further 110 (3.6% of all audited plans) were not approved by the audit due to deviations from radiotherapy treatment policy. A minority of these plans (22%) were modified prior to initiating treatment and the remainder provided important feedback for continuous quality improvement of treatment policies. CONCLUSION: A real-time audit of radiotherapy practice in a regional cancer center setting proved feasible and provided important direct and indirect patient benefits.

Historical origins of current problems in cancer control.

Canada's provinces have some of the most highly developed cancer control systems in the world, but the recent crisis in waiting times for radiotherapy has drawn attention to many weaknesses and inadequacies. Focusing on the province with the largest cancer control system, Ontario, this paper explores the historical origins of current problems in cancer control and shows that they are directly related to policy decisions made in the early years of the system. The development of cancer control in Ontario from the 1920s to the present is outlined, and the historical origins of 3 specific problems related to patient care are discussed: fragmentation of care, which has resulted from an emphasis on radiotherapy rather than comprehensive care and from tensions between the medical profession and government; variation in practice, which can be traced to the empirical origin of much cancer treatment and the slow implementation of research programs; and inequitable access to care, which can be attributed to the emphasis on geographic centralization of services. Attempts to reform Ontario's cancer control system are unlikely to be successful unless these fundamental issues are recognized and addressed.

Admissions to a radiation oncology inpatient service.

PURPOSE: Although the care of inpatients is an important aspect of radiation oncology practice in many countries, it has never been studied in detail. The goal of this study was to describe the admissions to a radiation oncology inpatient service over a 1-year period with respect to patient characteristics, primary malignancies, common nonmalignant diagnoses, use of radiotherapy and outcome of admission. METHOD: Using computerized hospital databases, we analysed the utilization of 11 radiation oncology beds in a 424-bed teaching hospital from March 31, 1991, to April 1, 1992. RESULTS: There were 342 admissions of 277 patients. The median age was 66.5 years; the male:female ratio was 1:1. The commonest primary neoplastic diagnoses were lung (42%), gynecological (15%), genitourinary (14%) and breast (8%) cancers. Only 17% of the patients had cancer as the sole diagnosis; most patients had multiple medical diagnoses. Infections (22%), neurological (20%), cardiovascular (13%) and endocrine (9%) conditions were the commonest. Mean length of stay was 11.25 days. Most of the admissions (71%) resulted in discharge to the patient's home; few patients (15%) died. Only half of admissions involved radiotherapy, indicating that the focus of patient care was the medical treatment of cancer complications or other active medical problems. CONCLUSION: These data show that radiation oncology inpatients have complicated medical problems, and they support the training of radiation oncologists in the comprehensive medical care of patients.

Medicalizing malignancy: the uneasy origins of Ontario's cancer program, 1929-34.

In the late 1020s, cancer was characterized as a public health problem for which urgent government attention was needed. Initially reluctant to become involved in cancer treatment, the government of Ontario was prompted by initiatives in other parts of Canada to establish a Royal Commission on the Use of X-Rays and Radium in 1931. The Commission recommended the purchase of radium and the establishment of a network of cancer clinics which became the framework of today's cancer system. This study explores the factors leading to the decision by the Ontario government to become involved in cancer and focuses on the role of the medical profession in shaping official response to the cancer problem. Despite the wish of the government to keep the Commission free from medical domination, the formulation of cancer policy became a struggle between two groups of doctors: specialists who believed in centralization and the organized medical profession which saw the state's involvement in cancer as a threat to its independence. This struggle resulted in a more fragmented and dispersed system than the comprehensive, centrally coordinated cancer system envisaged by the Commission.

Necrosis following radiotherapy for carcinoma of the pinna.

PURPOSE: Radiation therapy is often the preferred modality of treatment for carcinoma of the pinna because it avoids the cosmetic defect of surgery. However, radiation oncologists are sometimes reluctant to irradiate the ear because of the risk of subsequent necrosis. The goal of this study was to establish the long-term disease control and necrosis rates following irradiation of the external ear. METHODS AND MATERIALS: A retrospective analysis was undertaken of 138 courses of curative radiotherapy given to 128 patients for biopsy-proven basal (70 courses), squamous (62 courses), or mixed (6 courses) tumors of the pinna between January 1, 1982, and December 31, 1991, at the Kingston Regional Cancer Center. RESULTS: The median age of the patients was 73 (range 43-94) and the median size of the tumors was 12 mm (range 3-50 mm). Treatment was given using orthovoltage X rays (79) or electrons (59). The most common dose prescription was 35 Gy/5 fractions; total doses ranged from 17.50 to 64 Gy. The median follow-up is 58 months (range 6-149). The actuarial 5-year local control rate is 93%; the actuarial necrosis rate at 5 years is 13%. Most necroses healed with conservative management; only two patients required surgery for necrosis. We analyzed the following factors as possible predictors of radiation necrosis: patient age, size of lesion, histology, fraction size, total dose, overall time, and beam energy. Only daily fraction sizes > 6 Gy (p = 0.0093) and treatment times < 5 days (p = 0.0053) were significantly associated with an increased risk of necrosis. CONCLUSION: To reduce the risk of necrosis, radiation therapy for external ear cancer should be given using protracted fractionation.

Physics for physicians: integrating science into the medical curriculum, 1910-1950.

One of the most difficult problems in twentieth-century medical education has been finding ways to successfully integrate the basic and applied sciences into the medical curriculum. Not only have medical students regarded basic sciences such as physics and biochemistry with distaste, but these subjects traditionally have been taught by pure scientists with little interest in the needs of medical students. In this paper, the author reviews the history of physics teaching at the Queen's University Faculty of Medicine in Canada, placing particular emphasis on the work of J.K. Robertson (1885-1958), professor of physics. Although physics no longer has the relevance to general medical training that it once had a study of Robertson's ideas and methods provides insight into the process of integrating basic science into medical training. Robertson's success in the endeavor was based largely on two factors his "sympathetic understanding" of the needs of medical students and his innovative combination of basic and applied science in one course--factors that are as important to medical teaching today as they were 50 years ago.