How does problem-solving pedagogy affect creativity? A meta-analysis of empirical studies.

The purpose of this study was to investigate the effects of problem-solving pedagogy on individual students' creativity in different teaching contexts and conditions, and to examine the role of moderating variables that may affect the overall effect size. The study screened 19 relevant studies from the Web of Science for inclusion in the meta-analysis, and extracted 77 effect sizes from these studies that could be used in the meta-analysis. The study first explored the relationship between problem-solving pedagogy and the development of learner creativity, and further analysis focused on moderating variables to investigate the effects of instructional method, grouping method, grade level, problem-solving scaffolding, source of problems, the application of thinking tools, and the application of technology. The results showed that problem-solving pedagogy enhances students' creativity, while at the same time, among the sources of problems, student-discovered problems are most conducive to creativity stimulation, while teacher-determined problems and problems that lead to student discovery are less effective in terms of promoting creativity. Among the grouping methods, heterogeneous grouping can better utilize the creativity cultivation effect of the problem-solving pedagogy than random grouping and homogeneous grouping. Among the different levels of grades, learners in elementary school are better able to gain creativity under the influence of problem-solving pedagogy than learners in middle school, high school, college, and those in on-the-job learning. However, this study did not reveal any significant benefits for creativity enhancement under the four conditions of instructional method, problem-solving scaffolding, thinking tools-assisted, or technology. The results of this study clarify the importance of problem-solving pedagogy for creativity development, and also reveal the actual effects of the various ways of applying problem-solving pedagogy on creativity development as well as the problems that exist, which provides inspiration for how to better utilize problem-solving pedagogy in the future.

Ornamental plants associated with Buddhist figures in China.

BACKGROUND: In China, many ornamental plants associated with Buddhist figures, including the Sakyamuni, Bodhisattva, and Arhat, were grown and worshiped because of their cultural and religious significance. However, the systematic collation and ethnobotanical information about these culturally important plants have yet to be fully understood. METHODS: Online information was collected from 93 e-commercial platforms for ornamental plants all over China. Field sampling was conducted in 16 ornamental markets and 163 Buddhist temples using key informant interviews and participatory observation with traders, tourists, and local disciples. The types, distributions, and associated characteristics of the screened plants were summarized and the evolving characteristics of these ornamental plants were analyzed. RESULTS: A total of 60 ornamental plants, including six varieties and one subspecies, were screened, of which 43 species were associated with Sakyamuni, 13 with Bodhisattva, and four with Arhat. Among the 60 species, three were regarded as the Asoka tree related to Buddha's birth, ten as the Bodhi tree connected to Buddha's enlightenment, three as the Sal tree associated with Buddha's nirvana, nine were related to Buddha's head, belly, or hand, and 18 were connected with Buddha as lotus throne, bamboo monastery, or Bodhi beads. The evolving characteristics of these ornamental plants primarily constituted the substitution of the original plants by similar native plant species, followed by the introduced species with comparable morphology to the Buddhist figures. CONCLUSIONS: People grow ornamental plants associated with Buddhist figures to reflect their love and praise for plants and Buddha. The association between the ornamental plants and Buddhist figures will aid the inheritance of Buddhist culture and promote ornamental plants in the commercial market. Thus, the ethnobotany of ornamental plants associated with Buddhist figures can serve as a basis for future investigation of modern Buddhist culture.

Weak Magnetic Internal Signal Characteristics of Pipe Welds under Internal Pressure.

Weak magnetic detection technology is an effective method to identify stress-induced damage to ferromagnetic materials, and it especially possesses great application potential in long-distance oil and gas pipeline weld crack detection. In the process of pipeline operation, due to internal pressure and external loads, local stress concentration may be generated, and partial stress concentration may lead to local cracks and expansion of the pipe. In order to improve the accuracy of magnetic signal analysis for ferromagnetic materials under internal pressure, the causes of magnetic signal generation at pipeline welds were analyzed from a microscopic perspective. The distributions of magnetic signals at pipeline welds, weld cracks, and base metal cracks under different internal pressures were numerically analyzed. The variation trends of magnetic signal characteristics, such as peak values of axial and radial components, gradient K, maximum gradient Kmax, and gradient energy factor S(K), were analyzed. In addition, experiments were carried out to verify the numerical data. It was revealed that with the elevation of internal pressure, the peak values of the axial and radial components, gradient K, maximum gradient Kmax, and gradient energy factor S(K) linearly increased. However, the magnitude and average change of S(K) were larger, which can more directly indicate variations of magnetic signals. The radial growth rate νy of S(K) was 3.24% higher than the axial growth rate νx, demonstrating that the radial component of the magnetic signal was more sensitive to variations of stress. This study provided a theoretical and experimental basis for detection of stress-induced damage to long-distance oil and gas pipelines.

Long-Term Antipsychotic Effectiveness and Comparison of the Efficacy of Monotherapy and Polypharmacy in Schizophrenia: A 3-Years Follow-Up "Real World" Study in China.

Background: Discontinuation of antipsychotic treatment is a common problem in patients with schizophrenia and could reduce the effectiveness of treatment. Time to discontinuation (TTD) is one of the indicators of compliance and may also be an effective indicator of medication efficacy. The aim of the study was to compare the clinical effectiveness of quetiapine, olanzapine, risperidone, and aripiprazole in the real-world treatment of schizophrenia with 3-years follow-up. Method: A multi-center, open, cohort, prospective, real-world study was conducted. 706 patients were analyzed without intervention in medication selection and use, followed up for 3 years. Kaplan-Meier survival curves were used to draw the treatment discontinuation rates (TDR) curves at each time point. Cox proportional hazard regression model was used to assess the relative risk of TTD of antipsychotics. Results: There was a significant difference among monotherapy groups in all-cause antipsychotic treatment discontinuation (p = 0.0057). Among the four medications, the TDR of risperidone was the highest. Compared with polypharmacy, except for aripiprazole, the TDR of other three monotherapy medications were lower than that of polypharmacy, and olanzapine was statistically different (p = 0.0325). The cox regression analysis showed that after correction of Hochberg with multiple tests, only olanzapine had a relative risk lower than risperidone (p < 0.0083). Conclusions: The findings indicated that risperidone monotherapy and polypharmacy had the highest TDR and the shortest TTD. Olanzapine monotherapy had a relative risk lower than risperidone and was superior to polypharmacy.

Case Report: Herpes Simplex Virus Type 2 Acute Retinal Necrosis With Viral Encephalitis in Children.

Background: Few cases concerning acute retinal necrosis with viral encephalitis in children have been reported, especially cases where the fundus cannot be identified due to severe vitreous opacity in the early stage that makes diagnosis difficult. Methods: We conducted a retrospective review of an unusual case of herpes simplex virus-2 (HSV-2) acute retinal necrosis with viral encephalitis in an immunocompetent child, along with a review of relevant literature published up to September 2021. Result: An 11-year-old girl presented with an approximate 20-day history of ocular redness and decreased visual acuity in the left eye. Examination revealed anterior uveitis and vitreous opacity in the left eye. An anterior chamber tap was performed because the fundus could not be observed clearly, and the aqueous humor was positive for HSV-2 DNA. Cerebrospinal fluid also tested positive for HSV-2. She was diagnosed with acute retinal necrosis syndrome and viral encephalitis. The condition was controlled with timely antiviral and steroid therapy. She was also treated with prophylactic laser therapy to prevent retinal detachment during subsequent follow-up. The pathogenesis, diagnosis, and treatment of HSV-2 acute retinal necrosis in children and the association between acute retinal necrosis and viral encephalitis are further discussed, based on published literature. Conclusion: HSV-2-related pediatric acute retinal necrosis may be due to the acquisition of subclinical infection with HSV-2 during parturition, followed by reactivation of the virus latent in the body on account of certain factors. Moreover, it may be complicated with viral encephalitis. For suspected cases with invisible fundus, early intraocular fluid examination is especially helpful for differential diagnosis. Early diagnosis, early treatment, and timely prophylactic laser treatment to prevent retinal detachment are key to a better prognosis. Physicians need to pay attention to such suspected cases during diagnosis and treatment.

A Real-World Study of Risk Factors for QTc Prolongation in Schizophrenia Patients Receiving Atypical Antipsychotics.

PURPOSE: The risk of sudden cardiac death in patients receiving atypical antipsychotics may be related to QTc prolongation. The aim of this study was to investigate the risk factors for QTc prolongation to prevent QTc prolongation and guide clinical practice. METHODS: All electrocardiogram recordings of 913 schizophrenia patients who were receiving atypical antipsychotics were reviewed for prolonged QTc and associated conditions. Binary logistic regression analysis was used to investigate risk factors for QTc prolongation. RESULTS: Logistic regression analysis demonstrated that sex (odds ratio [OR], 0.386; P = 0.010), age (OR, 1.047; P = 0.000), high-density lipoprotein (OR, 0.257; P = 0.014), and antipsychotics dose (OR, 1.040; P = 0.036) were significantly associated with QTc prolongation. CONCLUSIONS: In patients with male sex, elder age, low high-density lipoprotein, or large antipsychotics dose, QTc should be monitored more frequently.

Characteristics and Spectrum of Cardiotoxicity Induced by Various Antipsychotics: A Real-World Study From 2015 to 2020 Based on FAERS.

Objective: This study aimed to investigate the characteristics and spectrum of cardiotoxicity induced by various antipsychotics based on the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. Methods: Data of the FAERS database from the first quarter of 2015 to the fourth quarter of 2020 were downloaded for disproportionality analysis. The significant signal was evaluated by reporting odds ratios and information components with statistical shrinkage transformation. Results: A total of 2,361,487 records were extracted for disproportionality analysis. Among the 10 antipsychotics, clozapine and amisulpride performed strong cardiotoxicity. Cardiomyopathy, cardiac arrhythmia, and Torsade de pointes/QT prolongation were the common cardiac adverse event induced by antipsychotics. Different characteristics of the spectrum of cardiotoxicity in various APs were discovered after further data mining. Moreover, evidence of the association between antipsychotics and eosinophilic myocarditis, peripartum cardiomyopathy was provided in this study. Conclusion: Antipsychotics presented cardiotoxicity in different degrees, and more cardiac examinations should be monitored in patients with antipsychotics.

Research on Features of Pipeline Crack Signal Based on Weak Magnetic Method.

Quantitative online detection of microcracks in long-distance oil and gas pipelines is an international problem, and the effective detection method is still lacking. In this paper, a mathematical model of non-uniform distribution of crack magnetic charges is established based on the stress distribution laws of pipeline cracks under internal pressure. The weak magnetic signal characteristics of pipeline cracks with different sizes are analyzed. The internal pressure increasing factor of weak magnetic signals are extracted to analyze the corresponding relationship between crack size and weak magnetic signals. The experimental study of the X70 pipeline is carried out. The results show that the axial component of the weak magnetic signal at the crack has a maximum value near the tip, and a minimum value appears in the middle of the crack. The internal pressure increasing factor is introduced to quantify the weak magnetic signal, the crack is in a safe state (not expanding) when the internal pressure increasing factor is positive, the weak magnetic signal has a linear relationship with the crack size. However, the crack is in a dangerous state when the internal pressure increasing factor is negative, and the pipeline crack will expand as the internal pressure increases.

Study on internal stress damage detection in long-distance oil and gas pipelines via weak magnetic method.

Weak magnetic stress detection is an important issue in oil-gas pipeline internal detection area. In order to verify the characteristics of weak magnetic stress internal detection signals, we built herein a magneto-mechanics equivalent model having a balanced magnetic field. First, we calculated the relationship between the stress and the weak magnetic signals; consequently, the analysis propagation laws of the weak magnetic signals with non-magnetic saturation were pointed out. Finally, the theoretical model was validated by a systematic experimental research. The analytical results show that a one-to-one linear link between the weak magnetic signals and the stress concentration is clear. Instead, the change of the weak magnetic signals with the liftoff is nonlinear, therefore we are proposing the Boltzmann liftoff correction factor whose degree of adaptability of the equivalent model can reach the value of 94%. It is possible to note that when the liftoff is in the approximate linear stage, the relevance ratio and the recognition rate of the magneto-mechanics curve show a high-quality. This conclusion is important in the engineering field for the set of the liftoff.