RESUMO
Aortic aneurysm is a vascular disease characterized by irreversible vasodilatation that can lead to dissection and rupture of the aortic aneurysm, a life-threatening condition. Thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) are two main types. The typical treatments for aortic aneurysms are open surgery and endovascular aortic repair, which are only indicated for more severe patients. Most patients with aneurysms have an insidious onset and slow progression, and there are no effective drugs to treat this stage. The inability of current animal models to perfectly simulate all the pathophysiological states of human aneurysms may be the key to this issue. Therefore, elucidating the molecular mechanisms of this disease, finding new therapeutic targets, and developing effective drugs to inhibit the development of aneurysms are the main issues of current research. Natural products have been applied for thousands of years to treat cardiovascular disease (CVD) in China and other Asian countries. In recent years, natural products have combined multi-omics, computational biology, and integrated pharmacology to accurately analyze drug components and targets. Therefore, the multi-component and multi-target complexity of natural products have made them a potentially ideal treatment for multifactorial diseases such as aortic aneurysms. Natural products have regained popularity worldwide. This review provides an overview of the known natural products for the treatment of TAA and AAA and searches for potential cardiovascular-targeted natural products that may treat TAA and AAA based on various cellular molecular mechanisms associated with aneurysm development.
RESUMO
Photosynthetic bacteria (PSB) technology is a promising method for biomass, protein, pigments, and other value-added substances generation from wastewater. However, the above bioresources production efficiency is relatively low. In this work, a static magnetic field (SMF) was used to promote bioresources production. Results showed that SMF had positive effects on value-added substances production. With 0.35 Tesla (T) SMF, the PSB biomass, protein, carotenoids, and bacteriochlorophyll concentration were promoted by 31.1%, 22.6%, 56.7%, and 73.1% compared with the control group, respectively. Biomass yield finally reached 0.58 g biomass/g COD removal, which was promoted by 37.1%. The doubling time was shortened by 37.9% in 0.35 T group, showing that SMF can promote cell growth. With 0.35 T SMF, the intracellular NADH dehydrogenase and ATP synthase activities concentration increased by 23.4% and 29.1%, respectively, thus increased the ATP content by 38.0%. Succinic dehydrogenase activity concentration greatly increased by 609.0% at 48 hr, which potentially accelerated the tricarboxylic acid cycle and COD degradation as well as enhanced biomass production. PRACTITIONER POINTS: SMF promoted PSB bioresource production during wastewater treatment processing. Biomass, protein, carotenoids, and Bchl concentration were promoted by 31.1%, 22.6%, 56.7%, and 73.1%, respectively. PSB yield of 0.35 T group was promoted by 37.1% compared with the control group. SDH concentration of 0.35 T was promoted by 609.0% compared with the control group. Increased NADH and ATP synthase activity concentration by SMF enhanced energy metabolism.
Assuntos
Águas Residuárias , Purificação da Água , Bactérias , Campos Magnéticos , FotossínteseRESUMO
Laser Raman Microprobe (LRM) is a micro-analytical technique for determining molecular components. Based on the summarization of the applications of LRM in petroleum exploration, the authors analyzed fluid inclusions (FI) and organic matters, and found that this technique could not only research qualitatively different phase components of single fluid inclusions and the types of organic substances, but also determine quantitatively each phase component of single fluid inclusions and the indexes of maturation of vitrinite. It is concluded that it is feasible to calculate the salinity of single FI by to sigmaB % NaCl = 61.183S - 22.173 and the reflectance (R0) of vitrinite by R0 (%) = 0.69 ln(82.12 D - 16,054.49) - 4.88.
