RESUMO
Occupational medicine, witness to the industrial and economic evolution of societies, has observed over time the link between diseases and occupational exposures. Nowadays, the transformation of societies brings out new risks, modulated by technical and organizational changes, and our knowledge of their impact on health is constantly evolving. The role of the occupational physician has not changed: he must question and observe in order to know and understand. Its purpose is the same, to prevent workers from falling ill because of their work. It remains essential to pay particular attention to the search for professional factors that may have influenced the disease since the identification and management of the cause is often the best treatment.
La médecine du travail, témoin de l'évolution industrielle et économique des sociétés, s'est intéressée au fil du temps au lien entre les maladies et les expositions professionnelles. De nos jours, la transformation des sociétés fait émerger de nouveaux risques, modulés par les changements techniques et organisationnels, et nos connaissances de leurs impacts sur la santé sont en constante évolution. Le rôle du médecin du travail n'a pas changé : il doit questionner et observer pour connaître et comprendre. Son but reste le même, éviter que les travailleurs ne tombent malades à cause de leur travail. Il demeure primordial d'accorder une attention particulière à la recherche de facteurs professionnels ayant pu influencer la maladie puisque l'identification et la gestion de la cause représentent bien souvent le meilleur traitement.
Assuntos
Doenças Profissionais , Exposição Ocupacional , Saúde Ocupacional , Medicina do Trabalho , Humanos , Masculino , Doenças Profissionais/prevenção & controle , Evolução SocialRESUMO
BACKGROUND: The flow cytometry CD63-based basophil activation test (Basotest has already been validated for the diagnosis of immediate-type allergy such as venom, house dust mite or cypress pollen allergies. The aim of this study was to evaluate the performance (specificity and sensitivity) of Basotest in the diagnosis of natural rubber latex allergy. METHODS: We included 46 latex allergic patients (clinical symptoms of latex allergy, positive latex skin prick tests and/or latex specific IgE) and 33 control subjects and performed Basotest on all subjects. RESULTS: The sensitivity and specificity of Basotest were 84.8 and 87.9%, respectively, when we considered the theoretic cut-off at 15% of CD63-positive cells. Using ROC curves, the optimal cut-off was evaluated at 22%, for which sensitivity and specificity were 79.3 and 96.7%, respectively. CONCLUSION: The Basotest is a reliable test in addition to clinical history and tests already validated (such as skin prick tests and specific IgE) to confirm the diagnosis of natural rubber latex allergy.