["Fast-Track" for laparoscopic-assisted rectum resection--what can be achieved? First results of a feasibility study]. / "Fast-Track" bei laparoskopisch assistierter Rektumresektion--was kann erreicht werden? Erste Ergebnisse einer Machbarkeitsstudie.

AIM: "Fast-track" multimodal rehabilitation is increasingly entering the perioperative management strategies in colon surgery aiming at minimized perioperative morbidity and accelerated recovery. So far little is known about the complementary effects of minimally invasive surgery along with "fast-track" rehabilitation in the treatment of rectal cancer. The aim of this pilot study was to investigate the influence of "fast-track" perioperative management on morbidity, recovery and length of hospital stay in laparoscopically-assisted rectum resections and to compare those data to earlier results. METHODS: An interdiciplinary "fast-track" multimodal rehabilitation strategy with avoidance of mechanical bowel cleansing, with a restrictive intravenous intra- and postoperative fluid regimen, forced mobilisation, and early enteral nutrition was introduced into clinical practice and applied in 16 laparoscopically-assisted rectum resections. Data were collected in the course af a prospective analysis. The mean patient age was 62 (42-79) years. RESULTS: Mean time of surgery was 245 (SD 46) min, and the mean intraoperative infusion rate was 11.2 (SD 2.6) ml/kg/BW. On day 2, 14 of the 16 patients tolerated solid food and 12 patients had had bowel movements. All patients returned to their initial body weight by day 4. The median postoperative hospital stay was 7.5 days (6-20), 12 patients were discharged between day 6 and 8. Two patients were readmitted for intestinal atony, one patient developed an anastomotic leakage. CONCLUSIONS: "Fast-track" rehabilitation is feasible in rectum surgery and seems to complement the beneficial effects of minimally invasive surgery without increasing the complication rate.

Aerosol photoemission for quantification of polycyclic aromatic hydrocarbons in simple mixtures adsorbed on carbonaceous and sodium chloride aerosols.

The photoelectric aerosol sensor was applied as a tool for the in situ and on-line detection of surface-enriched polycyclic aromatic hydrocarbons (PAHs). Carbon aerosol and sodium chloride aerosol were coated stepwise with up to four different PAHs or simultaneously with three different PAHs (internally mixed aerosol). The measured photoelectric signal of the internally mixed aerosol was compared with the expected signal, which was calculated from the previous calibration of the sensor. An additivity of the individual contributions of the absorbed PAHs on the sum signal was found. Experiments with photoelectrically inactive paraffin adsorbed on photoelectrically active aerosol particles have demonstrated that only the surface composition contributes to the photoemission signal.

Synchronizing temperatures and rRNA metabolism in Tetrahymena pyriformis.

1. In Tetrahymena pyriformis pre-rRNA is synthesized and efficiently processed and translocated into the cytoplasm at both a supraoptimal (34 degrees C) and a suboptimal (8 degrees C) synchronizing temperature. 2. At the heat shock temperature (34 degrees C) no substantial differences in the kinetics of the main intracellular events of rRNA-metabolism compared to the optimal growth temperature (28 degrees C) were found. 3. The high temperature, however, induces a strong retardation of uptake of [3H]adenosine into the cells and a reduction of the cellular ATP pool size. 4. At the cold shock temperature (8 degrees C) the rates of transcription and nucleocytoplasmic transport of rRNA as well as of nucleotide pool equilibration are reduced to a similar extent (25-30% of the optimal rates at 28 degrees C). 5. The results are discussed and compared with the effects of sub- and supraoptimal temperatures on rRNA synthesis and processing in mammalian cells.