RESUMO
MICRA, a compact Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer is described. The amount of miniaturisation in this device, based on a 1.24 T permanent magnet, remains compatible with genuine FT-ICR performance and analytical power in the mass range 2-1000 m/z, with a mass resolving power of 73,000 at mass 132. A first application of the transportability is the repetitive coupling of MICRA with a large-scale source of IR photons, the free electron laser CLIO.
RESUMO
The first example of direct structural characterization of polyaromatic ions by coupling a Fourier transform ion cyclotron resonance mass spectrometer with an infrared free-electron laser is presented. Measurement of the IR spectra of selectively prepared ionic reactive intermediates is allowed by the association of the high peak power and wide tunability of the laser with the flexibility of the spectrometer, where several mass selection and ion reaction steps can be combined, as demonstrated in the case of iron cation complexes of hydrocarbons. The present experimental setup opens the way to understanding chemical reaction paths.
RESUMO
The most common prescription medications encountered and recorded in the normal course of a death investigation by a medical examiner's office in a moderate-sized jurisdiction in an urban city are tallied, based on data collected from 2233 deaths reported in 1998. Medication history was available for 775 of these deaths and is reviewed in this study. The 25 most common medications are each briefly discussed, particularly adverse effects and possible toxicity of concern in the investigation of death. Medications to treat cardiovascular disease are by far the most commonly encountered. The 10 most common medications regardless of category were furosemide, digoxin, nitroglycerin, potassium, lisinopril, warfarin, albuterol, nifedipine, codeine, and amlodipine.
