Vacunación BCG con aguja bifurcada en recién nacidos / Use of bifurcated needle for BCG vaccination of newborns

Se ha sugerido que el método de la aguja bifurcada -usado con éxito contra la viruela_ podría emplearse ventajosamente para la vacunación BCG contra la tuberculosis en recién nacidos. Los dos estudios que se llevaron a cabo en Chile se efectuaron con objeto de confirmar las posibilidades al respecto y de reexaminar las dificultades que presentaba la aplicación del método (AU)

Use of the bifurcated needle for BCG vaccination of newborns

The bifurcated needle vaccination method used successfully against smallpox is a relatively simple technique that can be administered by personnel with only basic preparation and a minimum of training. This fact suggests that it could prove useful in campaigns of BCG vaccination against tuberculosis--especially for vaccination of newborns. With this end in mind, two studies were carried out in Santiago, Chile, to examine previously reported difficulties with the method and to assess its potential as an alternative to the best current method, that of intradermal inoculation. These studies indicated that previously reported variations in the results achieved by different vaccinators could be markedly reduced. However, they also found that the bifurcated needle method did not cause a sufficiently large dose of vaccine to enter the subject--even when fifteen needle strokes and a highly concentrated vaccine (160 mg per ml) were employed. It was thus concluded that although modification of the needle or other changes might ultimately yield satisfactory results, the bifurcated needle technique cannot yet be recommended for BCG vaccination of newborns (Au)

Use of the bifurcated needle for BCG vaccination of newborns

The bifurcated needle vaccination method used successfully against smallpox is a relatively simple technique that can be administered by personnel with only basic preparation and a minimum of training. This fact suggests that it could prove useful in campaigns of BCG vaccination against tuberculosis--especially for vaccination of newborns. With this end in mind, two studies were carried out in Santiago, Chile, to examine previously reported difficulties with the method and to assess its potential as an alternative to the best current method, that of intradermal inoculation. These studies indicated that previously reported variations in the results achieved by different vaccinators could be markedly reduced. However, they also found that the bifurcated needle method did not cause a sufficiently large dose of vaccine to enter the subject--even when fifteen needle strokes and a highly concentrated vaccine (160 mg per ml) were employed. It was thus concluded that although modification of the needle or other changes might ultimately yield satisfactory results, the bifurcated needle technique cannot yet be recommended for BCG vaccination of newborns (Au)

Evaluación de la vacuna combinada attenuvax-viruela en Chile / Evaluation of combined attenuvax-smallpox vaccine in Chile

Reactions to combined attenuvax-smallpox vaccine were studied, and were compared with those produced by each type of vaccine separately, in children from one to five years of age, controlled by maternal-child care centers under the National Health Service in Santiago, Chile. Combined freeze-dried and preblended attenuvax-smallpox vaccine and freeze-dried "Dryvax" smallpox vaccine were used. The combined vaccine was jet-injected, while the measles vaccine was administered in the form of subcutaneous injections, and the smallpox vaccine by the multipuncture technique

The new preblended and combined attenuvax-smallpox vaccine administered by jet injection produces general clinical reactions similar to or milder than those caused by each vaccine when administered separately

"Takes" were recorded in 96.9 per cent of children inoculated with the combined vaccine, which is an excellent result

To judge from the rise in titers in serological tests counts for both viruses in the cases inoculated, there was no evidence of interference between antigens. The conversion rate for each virus closely resembled that obtained when each vaccine was administered separately, and the geometric mean of the hemoagglutination inhibition titers was also very similar for the combined vaccine and for each vaccine administered separately

Revaccination against smallpox in children inoculated two months earlier with the ... (AU)

Vacunación BCG con aguja bifurcada en recién nacidos / Use of bifurcated needle for BCG vaccination of newborns

Se ha sugerido que el método de la aguja bifurcada -usado con éxito contra la viruela_ podría emplearse ventajosamente para la vacunación BCG contra la tuberculosis en recién nacidos. Los dos estudios que se llevaron a cabo en Chile se efectuaron con objeto de confirmar las posibilidades al respecto y de reexaminar las dificultades que presentaba la aplicación del método (AU)

Evaluación de la vacuna combinada attenuvax-viruela en Chile / Evaluation of combined attenuvax-smallpox vaccine in Chile

Reactions to combined attenuvax-smallpox vaccine were studied, and were compared with those produced by each type of vaccine separately, in children from one to five years of age, controlled by maternal-child care centers under the National Health Service in Santiago, Chile. Combined freeze-dried and preblended attenuvax-smallpox vaccine and freeze-dried "Dryvax" smallpox vaccine were used. The combined vaccine was jet-injected, while the measles vaccine was administered in the form of subcutaneous injections, and the smallpox vaccine by the multipuncture technique

The new preblended and combined attenuvax-smallpox vaccine administered by jet injection produces general clinical reactions similar to or milder than those caused by each vaccine when administered separately

"Takes" were recorded in 96.9 per cent of children inoculated with the combined vaccine, which is an excellent result

To judge from the rise in titers in serological tests counts for both viruses in the cases inoculated, there was no evidence of interference between antigens. The conversion rate for each virus closely resembled that obtained when each vaccine was administered separately, and the geometric mean of the hemoagglutination inhibition titers was also very similar for the combined vaccine and for each vaccine administered separately

Revaccination against smallpox in children inoculated two months earlier with the ... (AU)