[Refractory thrombotic thrombocytopenic purpura]. / Therapierefraktäre thrombotisch-thrombozytopenische Purpura.

Thrombotic thrombocytopenic purpura (TTP) remains a serious illness with potentially life-threatening complications. The following case of a TTP patient describes a serious relapse with exacerbation in spite of adequately initiated therapy and highlights the necessity of interdisciplinary expertise in the treatment of the disease.

[Progressive renal insufficiency in a 55-year-old man with psoriasis]. / Progrediente Niereninsuffizienz bei einem 55-jährigen Patienten mit Psoriasis.

Treatment with tumor necrosis factor alpha (TNF-α) inhibitors is a well-established therapeutic strategy for various autoimmune diseases. However, little is known about renal complications and possible causality of renal injury due to this treatment. The following case of a patient with psoriasis demonstrates the difficulties in classifying renal complications of anti-TNF-α therapy versus kidney involvement caused by the underlying disease.