RESUMO
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 B(p,n) 11 C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.
RESUMO
We report on the fabrication of three-dimensional waveguide beam splitters in a dielectric Bi(4)Ge(3)O(12) (BGO) crystal by direct femtosecond laser writing. In the laser written tracks of BGO crystal, positive refractive index is induced, resulting in so-called Type I configuration waveguiding cores. The "multiscan" technique is utilized to shape cores with designed cross-sectional geometry in order to achieve guidance at mid-infrared wavelength of 4 µm. The fundamental mode guidance along both TE and TM polarizations has been obtained in the waveguide structures. With this feature, we implement beam splitters from 2D to 3D geometries, and realize 1 × 2, 1 × 3, and 1 × 4 power splitting at 4µm.